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Electrophysiological signatures of veridical head direction in humans
Information about heading direction is critical for navigation as it provides the means to orient ourselves in space. However, given that veridical...
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Electrophysiological- and Neuropharmacological-Based Benchmarking of Human Induced Pluripotent Stem Cell-Derived and Primary Rodent Neurons
Human induced pluripotent stem cell (iPSC)-derived neurons are of interest for studying neurological disease mechanisms, develo** potential...
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The Electrophysiological Properties of Cortical Neurons in the Epileptic Foci of Children with Refractory Temporal Lobe Epilepsy
AbstractTemporal lobe epilepsy is a severe disorder of the central nervous system associated with an imbalance of excitation and inhibition in the...
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Esc peptides as novel potentiators of defective cystic fibrosis transmembrane conductance regulator: an unprecedented property of antimicrobial peptides
Mutations in the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein lead to persistent lung bacterial infections, mainly due to Ps...
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Electrophysiological Approaches to Studying the Suprachiasmatic Nucleus
In mammals, the part of the nervous system responsible for most circadian behavior can be localized to a bilaterally paired structure in the...
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Charge Transport by Light-Activated Rhodopsins Determined by Electrophysiological Recordings
Electrophysiological experiments are required to determine the ion transport properties of light-activated currents from microbial rhodopsin...
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Electrophysiology of Endocannabinoid Signaling
Electrophysiological technique is an efficient tool for investigating the synaptic regulatory effects mediated by the endocannabinoid system....
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Dissociation between phase and power correlation networks in the human brain is driven by co-occurrent bursts
Well-known haemodynamic resting-state networks are better mirrored in power correlation networks than phase coupling networks in electrophysiological...
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Temperature-robust rapid eye movement and slow wave sleep in the lizard Laudakia vulgaris
During sleep our brain switches between two starkly different brain states - slow wave sleep (SWS) and rapid eye movement (REM) sleep. While this...
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Electrophysiology of the Danio rerio Heart
AbstractTropical teleost fish Danio rerio is increasingly used as a model object for electrophysiological studies of human cardiac physiology and...
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Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity
Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their...
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Exploring oak processionary caterpillar induced lepidopterism (part 2): ex vivo bio-assays unmask the role of TRPV1
As human skin comes into contact with the tiny hairs or setae of the oak processionary caterpillar, Thaumetopoea processionea , a silent yet intense...
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Structural basis for NaV1.7 inhibition by pore blockers
Voltage-gated sodium channel Na V 1.7 plays essential roles in pain and odor perception. Na V 1.7 variants cause pain disorders. Accordingly, Na V 1.7 has...
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Modeling hypertrophic cardiomyopathy with human cardiomyocytes derived from induced pluripotent stem cells
One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is the poor availability of myocardial tissue samples at the...
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Transplanted neural lineage cells derived from dental pulp stem cells promote peripheral nerve regeneration
Cell therapy for peripheral nerve injury is a promising strategy as regenerative medicine that restores neurological function. However, challenges...
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Atrial Gene Painting in Large Animal Model of Atrial Fibrillation
Gene therapy appears promising as a targeted treatment of cardiac diseases. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia...
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Recombinant protein delivery enables modulation of the phototransduction cascade in mouse retina
Inherited retinal dystrophies are often associated with mutations in the genes involved in the phototransduction cascade in photoreceptors, a...
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Physiology of Ranvier Nodes in Living Myelinated Nerve Fibers
Abstract —A fixed histological preparation cannot reveal the dynamics of morphophysiological objects being merely a basis for hypothetic physiology....
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Generation of ‘semi-guided’ cortical organoids with complex neural oscillations
Temporal development of neural electrophysiology follows genetic programming, similar to cellular maturation and organization during development. The...
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Electrophysiology of ionotropic GABA receptors
GABA A receptors are ligand-gated chloride channels and ionotropic receptors of GABA, the main inhibitory neurotransmitter in vertebrates. In this...
