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Unveiling the impact of cryptic plasmids curing on Escherichia coli Nissle 1917: massive increase in Ag43c expression
Escherichia coli Nissle 1917 (EcN) is an important chassis strain widely used for the development of live biotherapeutic products (LBPs). EcN strain...
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Growth performance, mucosal immunity and disease resistance in goldfish (Carassius auratus) orally administered with Escherichia coli Strain Nissle 1917
The current research aimed to shed light on the efficacy of Escherichia coli strain Nissle 1917 (EcN) on goldfish (……) growth, gut immunity,...
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Comprehensive Analysis of the Physiological Characterization of Escherichia coli Nissle 1917
Escherichia coli Nissle 1917 (EcN) is one of the probiotics that has drawn more attention from researchers in recent days as it extends many host...
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Inhibition of bacterial swimming by heparin binding of flagellin FliC from Escherichia coli strain Nissle 1917
Escherichia coli Nissle1917 (EcN) is a non-pathogenic probiotic strain widely used to maintain gut health, treat gastrointestinal disorders, and...
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Development of probiotic E. coli Nissle 1917 for β-alanine production by using protein and metabolic engineering
Abstractβ-alanine has been used in food and pharmaceutical industries. Although Escherichia coli Nissle 1917 (EcN) is generally considered safe and...
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Identification and expression profiling of c-di-GMP signaling genes in the probiotic strain Escherichia coli Nissle 1917 during adhesion to the intestinal epithelial cells
Cyclic-di-GMP (c-di-GMP) is a ubiquitous signaling molecule in many microorganisms that orchestrates genetic regulation during the transition between...
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High-quality genome-scale metabolic network reconstruction of probiotic bacterium Escherichia coli Nissle 1917
BackgroundEscherichia coli Nissle 1917 (EcN) is a probiotic bacterium used to treat various gastrointestinal diseases. EcN is increasingly being...
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Nattokinase enhances the preventive effects of Escherichia coli Nissle 1917 on dextran sulfate sodium-induced colitis in mice
Nattokinase with excellent anti-thrombotic, anti-inflammatory, anti-tumor, and anti-hypertension properties has been used in the development of...
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Improved cryptic plasmids in probiotic Escherichia coli Nissle 1917 for antibiotic-free pathway engineering
AbstractThe engineered probiotic Escherichia coli Nissle 1917 (EcN) is expected to be employed in the diagnosis and treatment of various diseases....
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Enhancing tumor-specific recognition of programmable synthetic bacterial consortium for precision therapy of colorectal cancer
Probiotics hold promise as a potential therapy for colorectal cancer (CRC), but encounter obstacles related to tumor specificity, drug penetration,...
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Adjuvant Effects of Deleting Hypervariable Domains of FliC of Escherichia coli Nissle 1917
Bacterial flagellin (FliC) can be used as a TLR5 ligand-like adjuvant. However, the sequences of hypervariable regions(HVR) of FliC from different...
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Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria
Phenylketonuria (PKU), a disease resulting in the disability to degrade phenylalanine (Phe) is an inborn error with a 1 in 10,000 morbidity rate on...
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Escherichia coli Nissle 1917 secondary metabolism: aryl polyene biosynthesis and phosphopantetheinyl transferase crosstalk
AbstractEsc herichia col i Nissle 1917 (EcN) is a Gram-negative bacterium that is used to treat inflammatory bowel diseases. The probiotic character...
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Spectral dynamic causal modelling in healthy women reveals brain connectivity changes along the menstrual cycle
Longitudinal menstrual cycle studies allow to investigate the effects of ovarian hormones on brain organization. Here, we use spectral dynamic causal...
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The construction of a dual-functional strain that produces both polysaccharides and sulfotransferases
ObjectivesHeparosan is used as the starting polysaccharide sulfated using sulfotransferase to generate fully elaborate heparin, a widely used...
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High density fermentation of probiotic E. coli Nissle 1917 towards heparosan production, characterization, and modification
AbstractHeparosan is a naturally occurring non-sulfated glycosaminoglycan. Heparosan serves as the substrate for chemoenzymatic synthesis of...
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Metformin-loaded lecithin nanoparticles induce colorectal cancer cytotoxicity via epigenetic modulation of noncoding RNAs
BackgroundColorectal cancer (CRC) is major aliment around the word, with a cumulative rate of mortality. Metformin (MT) was recently approved as...
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Heparin stimulates biofilm formation of Escherichia coli strain Nissle 1917
ObjectivesEscherichia coli strain Nissle 1917 (EcN), a gut probiotic competing with pathogenic bacteria, has been used to attenuate various...
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Structure and biological activity in vitro of Flagellin and its mutants from Escherichia coli Nissle 1917
Bacterial flagellin is a potent immunomodulatory agent. Previously, we successfully obtained flagellin from Escherichia coli Nissle 1917 (FliC EcN )...
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Dual engineered bacteria improve inflammatory bowel disease in mice
AbstractCurrently, there are many different therapies available for inflammatory bowel disease (IBD), including engineered live bacterial...
