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New insights into fibrosis from the ECM degradation perspective: the macrophage-MMP-ECM interaction
Fibrosis is a pathological feature of a variety of chronic inflammatory diseases that can affect almost all organs, which can cause severe...
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Cell mediated ECM-degradation as an emerging tool for anti-fibrotic strategy
Investigation into the role of cells with respect to extracellular matrix (ECM) remodeling is still in its infancy. Particularly, ECM degradation is...
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Inference of long-range cell-cell force transmission from ECM remodeling fluctuations
Cells sense, manipulate and respond to their mechanical microenvironment in a plethora of physiological processes, yet the understanding of how cells...
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The ECM and tissue architecture are major determinants of early invasion mediated by E-cadherin dysfunction
Germline mutations of E-cadherin cause Hereditary Diffuse Gastric Cancer (HDGC), a highly invasive cancer syndrome characterised by the occurrence of...
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Role of oncostatin-M in ECM remodeling and plaque vulnerability
Atherosclerosis is a multifactorial inflammatory disease characterized by the development of plaque formation leading to occlusion of the vessel and...
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Organization, dynamics and mechanoregulation of integrin-mediated cell–ECM adhesions
The ability of animal cells to sense, adhere to and remodel their local extracellular matrix (ECM) is central to control of cell shape, mechanical...
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Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue
BackgroundAbdominal obesity is appreciated as a major player in insulin resistance and metabolically dysfunctional adipose tissue. Inappropriate...
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Identification and validation of an ECM organization-related gene signature as a prognostic biomarker and therapeutic target for glioma patients
BackgroundGlioma is the most common and devastating form of malignant brain tumor, with a poor prognosis. Extracellular matrix (ECM) organization is...
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Fibroblasts orchestrate cellular crosstalk in the heart through the ECM
Cell communication is needed for organ function and stress responses, especially in the heart. Cardiac fibroblasts, cardiomyocytes, immune cells and...
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Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Breast cancer exhibits the highest global incidence among all tumor types. Regardless of the type of breast cancer, metastasis is a crucial cause of...
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Injectable ECM Scaffolds for Cardiac Repair
Injectable biomaterials have been developed as potential minimally invasive therapies for treating myocardial infarction (MI) and heart failure....
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Liraglutide inhibits AngII-induced cardiac fibroblast proliferation and ECM deposition through regulating miR-21/PTEN/PI3K pathway
BackgroundCardiac fibrosis characterized with the aberrant proliferation of cardiac fibroblasts and extracellular matrix (ECM) deposition is a major...
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Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitates Injured Endometrial Restoring in Early Repair Period through miR-202-3p Mediating Formation of ECM
Endometrial damage repair disorder is the main reason of intrauterine adhesions (IUA) and thin endometrium (TA), which is caused by curettage or...
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STAT3 mediates ECM stiffness-dependent progression in ovarian cancer
The treatment of ovarian cancer remains a medical challenge and its malignant progression is connected with obvious changes in both tissue and cell...
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A tumor-derived type III collagen-rich ECM niche regulates tumor cell dormancy
Cancer cells disseminate and seed in distant organs, where they can remain dormant for many years before forming clinically detectable metastases....
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Identification of Brain ECM Binding Variable Lymphocyte Receptors Using Yeast Surface Display
Extracellular matrix (ECM) is a rich mixture of proteins and glycans secreted by cells. This includes typical ECM structures such as collagen and...
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Decellularized Extracellular Matrix (ECM) as a Model to Study Fibrotic ECM Mechanobiology
Aberrant deposition of the extracellular matrix (ECM) causes fibrosis and leads to ECM stiffening. This fibrotic ECM provides biological and...
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Integrative analysis of expression profile indicates the ECM receptor and LTP dysfunction in the glioma-related epilepsy
BackgroundSeizures are a common symptom in glioma patients, and they can cause brain dysfunction. However, the mechanism by which glioma-related...
