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Drug Repurposing: An Effective Tool in Modern Drug Discovery
AbstractDrug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the...
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Drug Repurposing: An Approach for Reducing Multidrug Resistance
Drug repurposing is paving ways to develop new therapeutic uses of old drugs which can be helpful in treatment of common and rare diseases. Multidrug...
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Identifying patterns to uncover the importance of biological pathways on known drug repurposing scenarios
BackgroundDrug repurposing plays a significant role in providing effective treatments for certain diseases faster and more cost-effectively....
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A novel efficient drug repurposing framework through drug-disease association data integration using convolutional neural networks
Drug repurposing is an exciting field of research toward recognizing a new FDA-approved drug target for the treatment of a specific disease. It has...
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Proteomic meta-study harmonization, mechanoty** and drug repurposing candidate prediction with ProHarMeD
Proteomics technologies, which include a diverse range of approaches such as mass spectrometry-based, array-based, and others, are key technologies...
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Drug Repurposing and Computational Drug Discovery for Viral Infections and COVID-19
Coronavirus that has caused severity in the present-day situation since 2019 has high morbidity and mortality rate leading to the pandemic. The...
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In Silico Pharmacology and Drug Repurposing Approaches
Drug repurposing is an innovative and resourceful approach to expanding access to treatment options by making new uses for medications that are...
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A comparative analysis of computational drug repurposing approaches: proposing a novel tensor-matrix-tensor factorization method
Efficient drug discovery relies on drug repurposing, an important and open research field. This work presents a novel factorization method and a...
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Drug repurposing and prediction of multiple interaction types via graph embedding
BackgroundFinding drugs that can interact with a specific target to induce a desired therapeutic outcome is key deliverable in drug discovery for...
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DrugRep-HeSiaGraph: when heterogenous siamese neural network meets knowledge graphs for drug repurposing
BackgroundDrug repurposing is an approach that holds promise for identifying new therapeutic uses for existing drugs. Recently, knowledge graphs have...
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Drug mechanism enrichment analysis improves prioritization of therapeutics for repurposing
BackgroundThere is a pressing need for improved methods to identify effective therapeutics for diseases. Many computational approaches have been...
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Network-based drug repurposing identifies small molecule drugs as immune checkpoint inhibitors for endometrial cancer
Endometrial cancer (EC) is the 6th most common cancer in women around the world. Alone in the United States (US), 66,200 new cases and 13,030 deaths...
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Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis
The development of new immunotherapies to treat the inflammatory mechanisms that sustain atherosclerotic cardiovascular disease (ASCVD) is urgently...
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Modulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin
Owing to the extensive prevalence of resistant bacteria to numerous antibiotic classes, antimicrobial resistance (AMR) poses a well-known hazard to...
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Machine Learning Applications in Drug Repurposing
The coronavirus disease (COVID-19) has led to an rush to repurpose existing drugs, although the underlying evidence base is of variable quality. Drug...
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Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy
BackgroundMonocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE)....
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Signature-Based Computational Drug Repurposing for Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease characterized by progressive loss of the upper and lower motor...
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Drug repurposing strategy II: from approved drugs to agri-fungicide leads
Epidemic diseases of crops caused by fungi deeply affected the course of human history and processed a major restriction on social and economic...
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Targeting notch signaling pathway in breast cancer stem cells through drug repurposing approach
Breast cancer is recognized globally as one of the leading causes of malignant morbidity. It is a heterogeneous disease that accounts for 30 percent...
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Drug repurposing strategy part 1: from approved drugs to agri-bactericides leads
Phytopathogenic bacteria are a major cause of crop mortality and yield reduction, especially in field cultivation. The lack of effective chemistry...
