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Preparation of Doxorubicin Liposomes by Remote Loading Method
Doxorubicin liposome is one of the most important nano-drug formulations. DOXIL, the first FDA-approved doxorubicin liposomes, is also the first...
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Nrf2: a dark horse in doxorubicin-induced cardiotoxicity
Being a broad-spectrum anticancer drug, doxorubicin is indispensable for clinical treatment. Unexpectedly, its cardiotoxic side effects have proven...
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Allicin Overcomes Doxorubicin Resistance of Breast Cancer Cells by Targeting the Nrf2 Pathway
Breast cancer (BC) is a lethal disorder that threatens the life safety of the majority of females globally, with rising morbidity and mortality year...
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STK32C modulates doxorubicin resistance in triple-negative breast cancer cells via glycolysis regulation
Understanding the mechanisms underlying doxorubicin resistance in triple-negative breast cancer (TNBC) holds paramount clinical significance. In our...
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Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells
Drug resistance represents a major problem in cancer treatment. Doxorubicin (adriamycin) is an injectable DNA intercalating drug that halts cancer...
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Enhancement of doxorubicin production in Streptomyces peucetius by genetic engineering and process optimization
Doxorubicin is an important class of anthracycline antitumor antibiotics produced by Streptomyces peucetius . The doxorubicin fermentation yield of...
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Toll-interacting protein may affect doxorubicin resistance in hepatocellular carcinoma cell lines
BackgroundLiver cancer is the third leading cause of cancer-related deaths worldwide, and hepatocellular carcinoma (HCC) is the most common type of...
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MALSU1-mediated regulation of mitochondrial function governs proliferation and doxorubicin resistance in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) poses a formidable challenge in oncology due to its aggressive nature and limited treatment options. Although...
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miRNAs as short non-coding RNAs in regulating doxorubicin resistance
The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disrupting proliferation and...
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Empagliflozin attenuates doxorubicin-impaired cardiac contractility by suppressing reactive oxygen species in isolated myocytes
In animal studies, sodium-glucose co-transporter-2 inhibitors—such as empagliflozin—have been shown to improve heart failure and impaired cardiac...
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Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin
Wilms tumor (WT) is the most common renal malignancy of childhood. Despite improvements in the overall survival, relapse occurs in ~15% of patients...
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Increased cellular senescence in doxorubicin-induced murine ovarian injury: effect of senolytics
Ovarian injury caused by chemotherapy can lead to early menopause, infertility, and even premature senility in female cancer patients, impairing the...
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Protective effects of arbutin against doxorubicin-induced cardiac damage
BackgroundDoxorubicin is an effective antineoplastic agent but has limited clinical application because of its cumulative toxicities, including...
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An Examination of the Role of Luteolin in Doxorubicin-Induced Testicular Damage
AbstractThe purpose of this study was to assess the impact of luteolin (LUT) on testicular histology and biochemical changes in rats subjected to...
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Profile of Molecular Markers of Cardiac Fibrosis in Rats Exposed to Different Doxorubicin Doses
AbstractThe study is devoted to investigating the profile of molecular markers of fibrosis in Wistar rats exposed to different doses of doxorubicin....
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Eupatilin attenuates doxorubicin-induced cardiotoxicity by activating the PI3K-AKT signaling pathway in mice
Eupatilin is a pharmacologically active flavonoid with a variety of biological activities, such as anticancer, anti-inflammatory, antioxidant,...
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Magnetic Thermosensitive Liposomes Loaded with Doxorubicin
Liposome-mediated anticancer drug deliveryDrug delivery has the advantage of limiting the massive cytotoxicity of chemotherapeutic agents....
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Morphology of Doxorubicin-Induced Organopathies under Different Intravenous Nicotinamide Riboside Administration Modes
AbstractDoxorubicin (DOX) is a potent chemotherapeutic drug, but its clinical use is hindered by significant side effects, it exerts on such vital...
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Effect of Doxorubicin on the Reactivity of Rat Mesenteric Arteries
AbstractDoxorubicin is widely used as an antitumor drug, but it has a negative effect on the cardiovascular system. While special attention has...
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A novel doxorubicin/CTLA-4 blocker co-loaded drug delivery system improves efficacy and safety in antitumor therapy
Doxorubicin’s antitumor effectiveness may be constrained with ineffective tumor penetration, systemic adverse effects, as well as drug resistance....
