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  1. Continuous Bioprocessing for Downstream

    Continuous biomanufacturing is increasingly considered as a way to intensify production of biopharmaceuticals and to reduce manufacturing costs by...
    Lukas Gerstweiler in Biopharmaceutical Manufacturing
    Chapter 2023
  2. Transcription Needs Translation Initiation of the Downstream Gene to Continue Downstream at Intercistronic Junctions in E. Coli

    We have reported a gal mutant called galE stop 0 , wherein the galE stop codon was changed to a sense codon. The experiment results demonstrated that...

    Heung ** Jeon, N. Monford Paul Abishek, ... Heon M. Lim in Current Microbiology
    Article 05 February 2024
  3. Downstream passage performance of silver eel at an angled rack: effects of behavior and morphology

    The European eel is critically endangered due to heavy impact of anthropogenic factors, such as habitat fragmentation, overexploitation and climate...

    Roman Motyka, Johan Watz, ... Olle Calles in Hydrobiologia
    Article Open access 13 April 2024
  4. TISSUE: uncertainty-calibrated prediction of single-cell spatial transcriptomics improves downstream analyses

    Whole-transcriptome spatial profiling of genes at single-cell resolution remains a challenge. To address this limitation, spatial gene expression...

    Eric D. Sun, Rong Ma, ... James Zou in Nature Methods
    Article 12 February 2024
  5. What are the common downstream molecular events between alcoholic and nonalcoholic fatty liver?

    Liver fat storage, also called hepatic steatosis, is increasingly common and represents a very frequent diagnosis in the medical field. Excess fat is...

    Giovanni Tarantino, Vincenzo Citro in Lipids in Health and Disease
    Article Open access 08 February 2024
  6. Fibroblast Growth Factor 23 Bone Regulation and Downstream Hormonal Activity

    Mineral homeostasis of calcium and phosphate levels is one critical component to the maintenance of bone mineral density (BMD) and strength. Diseases...

    Erica Clinkenbeard in Calcified Tissue International
    Article 12 June 2023
  7. River Sediments Downstream of Villages in a Karstic Watershed Exhibited Increased Numbers and Higher Diversity of Nontuberculous Mycobacteria

    The impact of residential villages on the nontuberculous mycobacteria (NTM) in streams flowing through them has not been studied in detail. Water and...

    Helena Modra, Vit Ulmann, ... Ivo Pavlik in Microbial Ecology
    Article Open access 16 December 2023
  8. Daily and Seasonal Variation in Downstream Migration of Juvenile Pink Salmon Oncorhynchus gorbuscha (Salmonidae) in Rivers across the Sakhalin and Kuril Region

    Abstract

    The four-year study outcomes for downstream migration of the juvenile Pink salmon Oncorhynchus gorbuscha in the Bolshaya Khuzi, Malaya...

    A. M. Kaev, L. V. Romasenko, G. N. Dzen in Journal of Ichthyology
    Article 25 June 2024
  9. GATA3 functions downstream of BRCA1 to promote DNA damage repair and suppress dedifferentiation in breast cancer

    Background

    Inadequate DNA damage repair promotes aberrant differentiation of mammary epithelial cells. Mammary luminal cell fate is mainly determined...

    Xuejie Wang, Feng Bai, ... **n-Hai Pei in BMC Biology
    Article Open access 16 April 2024
  10. ACE2 inhibits proliferation of smooth muscle cell through AT1R and its downstream signaling pathway

    To investigate the effect of the angiotensin converting enzyme 2 (ACE2) on AT1R expression, ERK1/2 and STAT3 protein phosphorylation in rat vascular...

    **g**g Gong, Zhuoqiang Lu, ... Xueqing ** in Journal of Biosciences
    Article 27 July 2023
  11. Low water temperature and increased discharge trigger downstream spawning migration of ayu Plecoglossus altivelis

    This study examined the combined effects of water temperature and discharge on the downstream spawning migration of ayu Plecoglossus altivelis , with...

    Shigeya Nagayama, Ryouji Fujii, ... Masanao Sueyoshi in Fisheries Science
    Article 22 May 2023
  12. Collaborative Governance for Reviving Tiber Landscapes Downstream of Rome

    The regeneration of river landscapes in urban and peri-urban areas is increasingly relevant on local agendas to promote integrated policies framing...
    Anna Laura Palazzo, Romina D’Ascanio in Cultivating Continuity of the European Landscape
    Chapter 2024
  13. Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway

    Estrogen excess in females has been linked to a diverse array of chronic and acute diseases. Emerging research shows that exposure to estrogen-like...

    **aorong Zhang, **nda Zhang, ... Hua Tian in Communications Biology
    Article Open access 10 July 2024
  14. Efficient Microfluidic Downstream Processes for Rapid Antibody Hit Confirmation

    Microfluidics has been recently applied to better understand the spatial and temporal progression of the immune response in several species, for tool...
    Ramona Gaa, Hannah Melina Mayer, ... Achim Doerner in Genotype Phenotype Coupling
    Protocol 2023
  15. Hydrologic Connectivity and Flow Generation from California Vernal Pool, Swale, and Headwater Stream Complexes to Downstream Waters

    Many headwater wetlands are integrated into flowpath networks and can serve as sources of streamflow for downgradient waters. We demonstrate this...

    Leanne M. Stepchinski, Mark C. Rains, ... Scott R. Stewart in Wetlands
    Article Open access 05 April 2023
  16. Experiment-based computational model predicts that IL-6 classic and trans-signaling exhibit similar potency in inducing downstream signaling in endothelial cells

    Inflammatory cytokine mediated responses are important in the development of many diseases that are associated with angiogenesis. Targeting...

    Min Song, Youli Wang, ... Aleksander S. Popel in npj Systems Biology and Applications
    Article Open access 21 September 2023
  17. Automated workflows using Quantitative Colour Pattern Analysis (QCPA): a guide to batch processing and downstream data analysis

    Animal and plant colouration presents a striking dimension of phenotypic variation, the study of which has driven general advances in ecology,...

    Cedric P. van den Berg, Nicholas D. Condon, ... Karen L. Cheney in Evolutionary Ecology
    Article Open access 16 March 2024
  18. Environmental Impacts Related to Upstream and Downstream Processing of Haematococcus pluvialis

    One of the most promising sources of astaxanthin is the microalgae Haematococcus pluvialis. Biotechnological methods of natural production of...
    Adriane Terezinha Schneider, Rosangela Rodrigues Dias, ... Eduardo Jacob-Lopes in Haematococcus
    Chapter 2023
  19. Statistical Designs to Improve Downstream Processing

    The efficient extraction and purificationPurification of recombinant proteins from leaf and seed Seeds tissues is often a challenging task,...
    Johannes F. Buyel in Recombinant Proteins in Plants
    Protocol 2022
  20. MethylC-analyzer: a comprehensive downstream pipeline for the analysis of genome-wide DNA methylation

    DNA methylation is a crucial epigenetic modification involved in multiple biological processes and diseases. Current approaches for measuring...

    Rita Jui-Hsien Lu, Pei-Yu Lin, ... Pao-Yang Chen in Botanical Studies
    Article Open access 06 January 2023
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