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Bioproduction of Cyclic Disulfide-Rich Peptides for Drug Modalities
Cyclic disulfide-rich peptides have extensive applications in drug development. These peptides are widely produced using solid-phase peptide...
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VenomFlow: An Automated Bioinformatic Pipeline for Identification of Disulfide-Rich Peptides from Venom Arsenals
Animal venoms are among the most complex natural secretions known, comprising a mixture of bioactive compounds often referred to as toxins. Venom...
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Yeast-based bioproduction of disulfide-rich peptides and their cyclization via asparaginyl endopeptidases
Cyclic disulfide-rich peptides have attracted significant interest in drug development and biotechnology. Here, we describe a protocol for producing...
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Fish Structural Proteins
Seafood is an important dietary constituent in human diet given its nutritive value and bioavailability of the nutritional components. The primary...
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Proteasomal degradation of misfolded proteins
One of the most important functions of cellular quality control systems is to maintain structural fidelity of proteins. Molecular chaperones prevent...
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Lipid transfer proteins: structure, classification and prospects of genetic engineering for improved disease resistance in plants
Plant non-specific lipid transfer proteins (nsLTPs) are small, basic, and cysteine-rich proteins found abundantly in higher plants. Apart from main...
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Extraction, Isolation, and Characterization Techniques of Structural Proteins
This chapter comprehensively explores the extraction methods, isolation techniques, and characterization approaches for structural proteins. It...
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Enzymatic Ligation of Disulfide-Rich Animal Venom Peptides: Using Sortase A to Form Double-Knotted Peptides
Sortase A is a thiol transpeptidase expressed by Gram-positive bacteria. This enzyme is capable of site-specifically ligating peptides containing the...
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Folding of newly synthesised proteins in the endoplasmic reticulum
The endoplasmic reticulum (ER) is a membranous compartment that can be found within any nucleated eukaryotic cell. Its job is to oversee the...
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Plant Proteomic Approaches, Expression of Simple Peptides to Complex Proteins
Plants are diverse, and their interactions with living organisms make them more versatile. The plants respond to biotic and abiotic interactions...
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Derivatives of Structural Proteins
This chapter explores the realms of marine proteins, focusing particularly on marine structural proteins and their derivatives. A thorough...
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Legume Seed: A Useful Platform for the Production of Medical Proteins/Peptides
Legumes are one of the most valuable food crops and nutritious staples of many cultures around the world. They are an economical source of...
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Preservation of corneous β-proteins in Mesozoic feathers
Fossil proteins are valuable tools in evolutionary biology. Recent technological advances and better integration of experimental methods have...
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Post-Translational Oxidative Modifications of Hemostasis Proteins: Structure, Function, and Regulation
AbstractReactive oxygen species (ROS) are constantly generated in a living organism. An imbalance between the amount of generated reactive species in...
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Non-enzymatic glycation: an essential modification of barley proteins affecting beer quality—brief review
This article focuses on the most important barley proteins and proteomic studies of barley in the brewing context. Barley ( Hordeum vulgare ) is one of...
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Identification of Peptides in Spider Venom Using Mass Spectrometry
Spider venoms are composed of hundreds of proteins and peptides. Several of these venom toxins are cysteine-rich peptides in the mass range of...
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Design and In Silico Evaluation of a Novel Cyclic Disulfide-Rich anti-VEGF Peptide as a Potential Antiangiogenic Drug
The vascular endothelial growth factor (VEGF) signaling pathway has a crucial role in regulating tumor angiogenesis. VEGF-A shows prominent...
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Formation of Supplementary Metal-Binding Centers in Proteins under Stress Conditions
AbstractIn many proteins, supplementary metal-binding centers appear under stress conditions. They are known as aberrant or atypical sites....
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Proteins Cross-talking with Nox Complexes: The Social Life of Noxes
Nox NADPH Oxidases exhibit a basic organization comprising a catalytic transmembrane subunit closely regulated by canonical regulatory subunits,...
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Factors involved in heterologous expression of proteins in E. coli host
The production of recombinant proteins is one of the most significant achievements of biotechnology in the last century. These proteins are produced...
