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Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel (Mytilus chilensis)
BackgroundDisseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted...
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Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia
Transmissible cancers are infectious parasitic clones that metastasize to new hosts, living past the death of the founder animal in which the cancer...
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Bone Neoplasia and Skeletal Dysplasia
Cancer is one of the most dangerous diseases and is widely recognized as a civilization disease related to the development of our civilization. The... -
A new molecular method for fast differentiation of cockles Cerastoderma edule and Cerastoderma glaucum
Cerastoderma edule and C. glaucum are two species of cockles that co-exist in European waters. They are morphologically similar but exhibit...
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Unravelling epigenetic mechanisms in Cerastoderma edule genome: a comparison of healthy and neoplastic cockles
Cancer is a multifaceted genetic disease characterized by the acquisition of several essential hallmarks. Notably, certain cancers exhibit horizontal...
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Somatic evolution of marine transmissible leukemias in the common cockle, Cerastoderma edule
Transmissible cancers are malignant cell lineages that spread clonally between individuals. Several such cancers, termed bivalve transmissible...
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VSSP-activated macrophages mediate senescence and tumor inhibition in a preclinical model of advanced prostate cancer
Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an...
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First detection of feline sporotrichosis (Sporothrix brasiliensis) at the zoonoses control service in Campo Grande, Mato Grosso do sul, Brazil
Sporotrichosis is a traumatic mycosis affecting the skin or subcutaneous tissues caused by Sporothrix dimorphic fungus. The fungal complex includes...
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Leukemia-Like Cancer in Bivalves
AbstractThe present review summarizes information available in the published literature on the distribution of disseminated neoplasia, or malignant...
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Fungal Diseases and Therapy in Dogs
Fungi may cause a wide variety of diseases from localized infections to fatal disseminated diseases in animals and humans. Fungal diseases have... -
Comparative analysis of the Mercenaria mercenaria genome provides insights into the diversity of transposable elements and immune molecules in bivalve mollusks
BackgroundThe hard clam Mercenaria mercenaria is a major marine resource along the Atlantic coasts of North America and has been introduced to other...
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Immune-mediated hematological disease in dogs is associated with alterations of the fecal microbiota: a pilot study
BackgroundThe dog is the most popular companion animal and is a valuable large animal model for several human diseases. Canine immune-mediated...
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The Hallmarks of Circulating Hybrid Cells
While tumor metastases represent the primary driver of cancer-related mortality, our understanding of the mechanisms that underlie metastatic... -
Role of Gut Microbiota in Predisposition to Colon Cancer: A Narrative Review
Globally, colorectal cancer (CRC) is a leading cause of cancer-related mortality. Dietary habits, inflammation, hereditary characteristics, and gut...
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The Historical Burden of Sporotrichosis in Brazil: a Systematic Review of Cases Reported from 1907 to 2020
Sporotrichosis is a cosmopolitan subcutaneous mycosis caused by Sporothrix species. Recently, this mycosis has gained notoriety due to the appearance...
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Ophthalmology of Psittaciformes: Parrots and Relatives
Psittaciformes is an ancient order among modern birds, distributed across over 90 genera totaling nearly 400 species (Forshaw 1989; Sibley and... -
Parathyroid Tumor Microenvironment
Parathyroid tumors are the second most common endocrine neoplasia, and it is almost always associated with hypersecretion of the parathormone (PTH),... -
Single-cell profiling to explore pancreatic cancer heterogeneity, plasticity and response to therapy
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer entity characterized by a heterogeneous genetic landscape and an immunosuppressive...
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Cancer Stem Cells are Actually Stem Cells with Disordered Differentiation: the Monophyletic Origin of Cancer
Cancer stem cells (CSCs) play an important role in cancer development. Based on advancements in CSC research, we propose a monophyletic model of...