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Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells
BackgroundThe phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR . Here, we...
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Inhibitors of Oxytosis/Ferroptosis: A New Class of Therapeutics for Alzheimer’s Disease
Alzheimer’s disease is a progressive neurological disorder that affects the brain, causing problems with memory, thinking, and behavior. It is the...
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Viral cross-class transmission results in disease of a phytopathogenic fungus
Interspecies transmission of viruses is a well-known phenomenon in animals and plants whether via contacts or vectors. In fungi, interspecies...
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High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits
Antigen discovery technologies have largely focused on major histocompatibility complex (MHC) class I-restricted human T cell receptors (TCRs),...
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Global, in situ analysis of the structural proteome in individuals with Parkinson’s disease to identify a new class of biomarker
Parkinson’s disease (PD) is a prevalent neurodegenerative disease for which robust biomarkers are needed. Because protein structure reflects...
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A machine learning approach using conditional normalizing flow to address extreme class imbalance problems in personal health records
BackgroundSupervised machine learning models have been widely used to predict and get insight into diseases by classifying patients based on personal...
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HLA-Clus: HLA class I clustering based on 3D structure
BackgroundIn a previous paper, we classified populated HLA class I alleles into supertypes and subtypes based on the similarity of 3D landscape of...
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Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data
BackgroundThe Human Leukocyte Antigen (HLA) genes are a group of highly polymorphic genes that are located in the Major Histocompatibility Complex...
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Automated System for Comprehensive Plant Disease Analysis
This chapter highlights the importance of automated plant disease analysis for agricultural enhancement. It addresses two critical challenges:...
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Multi-class boosting for the analysis of multiple incomplete views on microbiome data
BackgroundMicrobiome dysbiosis has recently been associated with different diseases and disorders. In this context, machine learning (ML) approaches...
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High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
Identification of CD8 + T cell epitopes is critical for the development of immunotherapeutics. Existing methods for major histocompatibility complex...
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CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma
Abnormal expression of Cylindromatosis (CYLD), a tumor suppressor molecule, plays an important role in tumor development and treatment. In this work,...
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Heart Valve Disease
This chapter was designed to provide the reader with a brief overview of the current treatment options for human heart valve disease. Major topics of...
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Revisiting the use of disease index and of disease scores in plant pathology
Plant disease assessment often involves the use of rating scores e.g., “0, 1, 2, … 6”, to rapidly record disease severity. Scores are ordinal, but...
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Celiac Disease: Myth or Reality
The amount and quality of wheat gluten which includes heterogeneous mixtures of storage proteins, namely glutenin and gliadin, are accepted as the...
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Mucormycosis: A Rare disease to Notifiable Disease
Mucormycosis is the third most frequent invasive mycosis, following candidiasis and aspergillosis. It is frequently neglected due to its rare...
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Multi-omics in Human Disease Biomarker Discovery
Sequencing of the human genome has been a major breakthrough that has paved the way to understand the biological functions of various biomolecules....
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Plant chitinases: Types, structural classification, antifungal potential and transgenic expression in plants for enhanced disease resistance
Plant chitinases are generally endochitinases that are usually expressed in different parts of a plant like stems, flowers, seeds and tubers. These...
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Prediction of Plant Disease Using Artificial Intelligence
Plant diseases are a persistent threat to global food security due to their ability to damage crops. They account for 20–40% of loss of global food...
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Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis
Metabolic demands fluctuate rhythmically and rely on coordination between the circadian clock and nutrient-sensing signalling pathways, yet...
