Search
Search Results
-
Dipeptidyl peptidase-4 inhibitors alleviate cognitive dysfunction in type 2 diabetes mellitus
BackgroundPatients with type 2 diabetes mellitus (T2DM) are commonly at high risk for develo** cognitive dysfunction. Antidiabetic agents might be...
-
In vitro characterization of lactic acid bacterial strains isolated from fermented foods with anti-inflammatory and dipeptidyl peptidase-IV inhibition potential
Probiotics are known to stimulate, modulate, and regulate host immune response by regulating specific sets of genes and improve glucose homeostasis...
-
Identifying Dipeptidyl Peptidase-IV Inhibitory Peptides Based on Correlation Information of Physicochemical Properties
Dipeptidyl peptidase-IV (DPP-IV) inhibitory peptides play a crucial role in drug development and the treatment of diabetes. Thus, it is an urgent...
-
Influence of Dipeptidyl Peptidase-4 (DPP4) on Mesenchymal Stem-Cell (MSC) Biology: Implications for Regenerative Medicine – Review
Dipeptidyl peptidase IV (DPP4) is a ubiquitous protease that can be found in membrane-anchored or soluble form. Incretins are one of the main DPP4...
-
Aspergillus oryzae PrtR alters transcription of individual peptidase genes in response to the growth environment
AbstractAspergillus oryzae PrtR is an ortholog of the transcription factor PrtT, which positively regulates the transcription of extracellular...
-
Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis
Peritoneal dialysis (PD) possesses multiple advantages for end stage renal disease. However, long-term PD triggers peritoneal fibrosis (PF). From the...
-
Discovery, synthesis and in combo studies of Schiff’s bases as promising dipeptidyl peptidase-IV inhibitors
AbstractDiabetes mellitus is a main global health apprehension. Macrovascular illnesses, neuropathy, retinopathy, and nephropathy are considered some...
-
Dipeptidyl peptidase-IV inhibitory peptides derived from salmon milt and their effects on postprandial blood glucose level
The hydrolysate of Oncorhynchus keta (chum salmon) milt was found to exhibit strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), and...
-
Dipeptidyl peptidase-4 (DPP4) inhibitor sitagliptin alleviates liver inflammation of diabetic mice by acting as a ROS scavenger and inhibiting the NFκB pathway
As a common chronic metabolic disease, the development of diabetes mellitus (DM) may also be accompanied by liver damage and inflammatory disorders....
-
Characterization of the recombinant PepX peptidase from Lactobacillus fermentum and its effect on gliadin protein hydrolysis in vitro
Wheat, one of the leading human food staples, contains proteins called glutens resistant to digestion. 1 to 2% of the world population is allergic to...
-
Immunoelectron Microscopic Analysis of Dipeptidyl-Peptidases and Dipeptide Transporter Involved in Nutrient Acquisition in Porphyromonas gingivalis
Porphyromonas gingivalis is an asaccharolytic, Gram-negative, anaerobic bacterium representing a keystone pathogen in chronic periodontitis. The...
-
The dipeptidyl peptidase-4 expression in some MERS-CoV naturally infected dromedary camels in Saudi Arabia 2018–2019
MERS-CoV usually causes respiratory and renal failure in some patients, which may be the underlying cause of death. Dromedary camels are the only...
-
Fast and accurate genome-wide predictions and structural modeling of protein–protein interactions using Galaxy
BackgroundProtein–protein interactions play a crucial role in almost all cellular processes. Identifying interacting proteins reveals insight into...
-
On the Presence of Gluten-Cleaving Activity in Sodiomyces alkalinus and S. magadiensis Strains
AbstractSpecial enzymes are necessary for producing gluten-free foods, and specific proteolytic enzymes with gluten-degrading activity may be used as...
-
Synthesis of 1,2,3-Triazole Analogs of Linagliptin as Novel DPP-4 Inhibitors: DFT, Molecular Docking Approach
AbstractThe synthesis of some novel 1,2,3-triazole-based linagliptin derivatives from the CuI catalyzed 1,3-dipolar cycloaddition reaction between N -...
-
Purification and biochemical characterization of a novel secretory dipeptidyl peptidase IV from porcine serum
Purification of DPP-IV enzyme from porcine serum, is presented in this study for the first time. The high molecular weight DPP-IV from porcine serum...
-
Gut microbiota DPP4-like enzymes are increased in type-2 diabetes and contribute to incretin inactivation
BackgroundThe gut microbiota controls broad aspects of human metabolism and feeding behavior, but the basis for this control remains largely unclear....
-
p53 and Ferroptosis
Ferroptosis is a form of oxidative cell death that relies on intracellular iron accumulation and lipid peroxidation. Recent studies have shown that...
-
Preparation and Purification of Recombinant Dipeptidyl Peptidase 4 from Tenebrio molitor
AbstractDipeptidyl peptidase 4—is a unique proline-specific peptidase, capable to hydrolyze the bonds, formed by proline amino acid residue, cleaving...
-
SGLT2 inhibitor promotes mitochondrial dysfunction and ER-phagy in colorectal cancer cells
BackgroundSodium-glucose transporter 2 (SGLT2) inhibitors (iSGLT2) are approved medications for type 2 diabetes. Recent studies indicate that iSGLT2...
