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Skeletal Muscle Receptors
This amazing chapter takes a deep dive into the realm of skeletal muscle receptors, particularly emphasizing the Vitamin D receptor (VDR) and the...
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The Neuromotor Junction
The neuromuscular junction (NMJ) is a pivotal point of interest in skeletal muscle physiology. This chapter dives into the innovative research in the...
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Biophysical reviews top five: voltage-dependent charge movement in nerve and muscle
The discovery of gating currents and asymmetric charge movement in the early 1970s represented a remarkable leap forward in our understanding of the...
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Excitation-contraction coupling in skeletal muscle: recent progress and unanswered questions
Excitation-contraction coupling (ECC) is a physiological process that links excitation of muscles by the nervous system to their mechanical...
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Mechanisms of eccentric contraction-induced muscle damage and nutritional supplementations for mitigating it
Eccentric contraction (ECC) often results in large and long-lasting force deficits accompanied by muscle soreness, primarily due to muscle damage. In...
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Nanopattern surface improves cultured human myotube maturation
BackgroundIn vitro maturation of human primary myoblasts using 2D culture remains a challenging process and leads to immature fibers with poor...
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Quantal Properties of Voltage-Dependent Ca2+ Release in Frog Skeletal Muscle Persist After Reduction of [Ca2+] in the Sarcoplasmic Reticulum
In skeletal muscle, the Ca 2+ release flux elicited by a voltage clamp pulse rises to an early peak that inactivates rapidly to a much lower steady...
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Assessment of Cell Viability in Electrically Excitable Muscle Cells Through Intact Twitch Stimulation
Muscle cells (i.e. skeletal muscle fibers) are fully viable and functional when their excitation-contraction (EC) coupling machinery is intact. This...
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Skeletal Muscle Energy Metabolism & Contraction
Skeletal muscle contraction and energy metabolism are closely intertwined processes essential for maintaining physiological functions and supporting...
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Molecular and cellular basis of genetically inherited skeletal muscle disorders
Neuromuscular disorders comprise a diverse group of human inborn diseases that arise from defects in the structure and/or function of the muscle...
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The Role of P2Y Receptors in the Regulation of Atrophic Processes in Rat Skeletal Muscles under Unloading
AbstractSkeletal muscle atrophy during their unloading is due to a decrease in protein synthesis and an increase in proteolysis. The accumulation of...
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A draft genome of Drung cattle reveals clues to its chromosomal fusion and environmental adaptation
Drung cattle ( Bos frontalis ) have 58 chromosomes, differing from the Bos taurus 2 n = 60 karyotype. To date, its origin and evolution history have not...
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Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies
Ryanodine receptors (RyRs) are huge homotetrameric Ca 2+ release channels localized to the sarcoplasmic reticulum. RyRs are responsible for the...
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Mechanisms of weakness in Mdx muscle following in vivo eccentric contractions
Skeletal muscle of the dystrophin-deficient mdx mouse is hypersensitive to eccentric (ECC) contraction-induced strength loss due to plasmalemmal...
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Preadaptivity of Noncontractile Thermogenesis in the Evolution of Warm-Bloodedness in Vertebrates
AbstractMost of the heat that is released in the vertebrate body is produced in the muscles during contractile (during movement or trembling) and...
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Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads
Here we show that striated muscle preferentially expressed protein kinase α (Spegα) maintains cardiac function in hearts with Spegβ deficiency. Speg...
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Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes
BackgroundPolymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can...
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A neuromuscular perspective of sarcopenia pathogenesis: deciphering the signaling pathways involved
The escalation of life expectancy is accompanied by an increase in the prevalence of age-related conditions, such as sarcopenia. Sarcopenia, a muscle...
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MRTF-A regulates Ca2+ release through CACNA1S
Gene therapy is considered a potential treatment for Duchenne muscular dystrophy (DMD). Researchers have been working on this for many years to find...
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Role of defective Ca2+ signaling in skeletal muscle weakness: Pharmacological implications
The misbehaving attitude of Ca 2+ signaling pathways could be the probable reason in many muscular disorders such as myopathies, systemic disorders...
