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Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3′-end modifications
The human let-7 miRNA family consists of thirteen members that play critical roles in many biological processes, including development timing and...
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DiCleave: a deep learning model for predicting human Dicer cleavage sites
BackgroundMicroRNAs (miRNAs) are a class of non-coding RNAs that play a pivotal role as gene expression regulators. These miRNAs are typically...
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DICER: structure, function, and regulation
Regulation of gene expression by small non-coding RNAs, such as miRNAs and siRNAs, is an inherent part of complex biological processes that allow...
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Structural basis of microRNA processing by Dicer-like 1
MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes by directly binding to their mRNAs. In animals, pri-miRNAs...
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Exogenous and endogenous dsRNAs perceived by plant Dicer-like 4 protein in the RNAi-depleted cellular context
BackgroundIn plants, RNase III Dicer-like proteins (DCLs) act as sensors of dsRNAs and process them into short 21- to 24-nucleotide (nt) (s)RNAs....
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Induction of RAC1 protein translation and MKK7/JNK-dependent autophagy through dicer/miR-145/SOX2/miR-365a axis contributes to isorhapontigenin (ISO) inhibition of human bladder cancer invasion
Although our previous studies have identified that isorhapontigenin (ISO) is able to initiate autophagy in human bladder cancer (BC) cells by...
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Antisense noncoding mitochondrial RNA-2 gives rise to miR-4485-3p by Dicer processing in vitro
BackgroundThe antisense noncoding mitochondrial RNAs (ASncmtRNAs) derive from the mitochondrial 16S gene. Knockdown of these transcripts with...
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RNA and DNA G-quadruplexes bind to human dicer and inhibit its activity
Guanine (G)-rich single-stranded nucleic acids can adopt G-quadruplex structures. Accumulating evidence indicates that G-quadruplexes serve important...
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ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites
BackgroundHuman dicer is an enzyme that cleaves pre-miRNAs into miRNAs. Several models have been developed to predict human dicer cleavage sites,...
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Generation of Self-Inhibitory Recombinant Viral Hemorrhagic Septicemia Virus (VHSV) by Insertion of Viral P Gene-Targeting Artificial MicroRNA into Viral Genome and Effect of Dicer Gene Knockout on the Recombinant VHSV Replication
To produce artificial microRNA (amiR)-mediated self-inhibitory viral hemorrhagic septicemia virus (VHSV), we inserted VHSV P gene-targeting amiR...
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Identification and characterization of Dicer-like genes in leaf rust pathogen (Puccinia triticina) of wheat
Puccinia triticina ( P. triticina ) is one of the most devastating fungal pathogens of wheat which causes significant annual yield loss to the crop....
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Differences in the Drosha and Dicer Cleavage Profiles in Colorectal Cancer and Normal Colon Tissue Samples
AbstractHuman colorectal adenocarcinoma cell line Caco-2 is often used as a model of healthy intestinal epithelium, in particular, in miRNA studies....
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Hippo/MST blocks breast cancer by downregulating WBP2 oncogene expression via miRNA processor Dicer
WBP2 transcription coactivator is an emerging oncoprotein and a key node of convergence between EGF and Wnt signaling pathways. Understanding how...
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TDP-43 prevents retrotransposon activation in the Drosophila motor system through regulation of Dicer-2 activity
BackgroundMutations in the small RNA-binding protein TDP-43 lead to the formation of insoluble cytoplasmic aggregates that have been associated with...
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The RNA–RNA base pairing potential of human Dicer and Ago2 proteins
The ribonuclease Dicer produces microRNAs (miRNAs) and small interfering RNAs that are handed over to Ago proteins to control gene expression by...
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Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
BackgroundThe maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate...
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The length of uninterrupted CAG repeats in stem regions of repeat disease associated hairpins determines the amount of short CAG oligonucleotides that are toxic to cells through RNA interference
Extended CAG trinucleotide repeats (TNR) in the genes huntingtin ( HTT ) and androgen receptor ( AR ) are the cause of two progressive neurodegenerative...
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microRNAs shape social immunity: a potential target for biological control of the termite Reticulitermes chinensis
Eusocial insects can employ various behavioural and physiological disease defences to avoid, resist and tolerate pathogen infections in their closely...
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Identification and expression analysis of 21-nt and 24-nt phased small interfering RNAs in maize tissues
Phased secondary small interfering RNAs (phasiRNAs) are generated by double-stranded RNA (dsRNAs), which are cleaved by Dicer as a phase set....
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Regulation of MicroRNAs
MicroRNAs are RNAs of about 18–24 nucleotides in lengths, which are found in the small noncoding RNA class and have a crucial role in the...