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Macrophages regulate healing-associated fibroblasts in diabetic wound
BackgroundRecovery from a foot ulcer is compromised in a diabetic status, due to the impaired tissue microenvironment that consists of altered...
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Role of exosome-derived miRNAs in diabetic wound angiogenesis
Chronic wounds with high disability are among the most common and serious complications of diabetes. Angiogenesis dysfunction impair wound healing in...
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The physiological phenomenon and regulation of macrophage polarization in diabetic wound
Macrophages play a crucial role in regulating wound healing, as they undergo a transition from the proinflammatory M1 phenotype to the proliferative...
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Genome-wide screening of m6A profiling of cutaneous wound healing in diabetic mice
ObjectiveImpaired wound healing in diabetes mellitus (DM) is a major health burden on patients, their families, and society. The present study aimed...
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Exosomes Derived from Mouse Breast Carcinoma Cells Facilitate Diabetic Wound Healing
BACKGROUND:Exosomes derived from breast cancer have been reported to play a role in promoting cell proliferation, migration, and angiogenesis, which...
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Defective NCOA4-dependent ferroptosis in senescent fibroblasts retards diabetic wound healing
Cellular senescence describes a state of permanent proliferative arrest in cells. Studies have demonstrated that diabetes promotes the pathological...
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Apigenin accelerates wound healing in diabetic mice by promoting macrophage M2-type polarization via increasing miR-21 expression
The alteration of inflammatory phenotype by macrophage polarization plays an important role in diabetic wound repair. Apigenin has been reported to...
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Phosphorylated chitosan accelerates dermal wound healing in diabetic wistar rats
Phosphorylated chitosan (PC), a water-soluble derivative of chitosan possesses several biological and chemical properties suitable for diabetic wound...
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Low-glucose culture environment can enhance the wound healing capability of diabetic adipose-derived stem cells
BackgroundApplication of autologous adipose-derived stem cells (ASC) for diabetic chronic wounds has become an emerging treatment option. However,...
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Mechanisms of Nrf2 and NF-κB pathways in diabetic wound and potential treatment strategies
The issue of delayed wound healing or nonhealing in diabetic patients presents a challenge for modern medicine. A number of attempts have been made...
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Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing
Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is...
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PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
During the process of wound healing, fibroblasts migrate to the wound site and perform essential functions in promoting cell proliferation, as well...
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Therapeutic Potential of Green Synthesized Silver Nanoparticles for Promoting Wound-Healing Process in Diabetic Mice
Diabetes is a serious metabolic disorder characterized by abnormal glucose levels in the body. Delayed wound healing is a severe diabetes...
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Effect of Hydroalcoholic Extract of Chamomile, Aloe Vera, and Green Tea on the Diabetic Wound in Rats
This investigation was designed to reveal the wound-curing properties of hydroalcoholic extract of Chamomile, Aloe Vera, and Green Tea on dermal...
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High glucose-induced STING activation inhibits diabetic wound healing through promoting M1 polarization of macrophages
Diabetic wound (DW) is characterized by elevated pro-inflammatory cytokines and cellular dysfunction consistent with elevated reactive oxygen species...
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Single-cell RNA-Seq analysis of diabetic wound macrophages in STZ-induced mice
The crucial role of macrophages in the healing of chronic diabetic wounds is widely known, but previous in vitro classification and marker genes of...
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Exosomes Derived from Human Amniotic Mesenchymal Stem Cells Facilitate Diabetic Wound Healing by Angiogenesis and Enrich Multiple lncRNAs
Background:Diabetic wound healing remains a major challenge due to the impaired functionality of angiogenesis by persistent hyperglycemia....
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Sex difference on fibroblast growth factors (FGFs) expression in skin and wound of streptozotocin(STZ)-induced type 1 diabetic mice
BackgroundFibroblast growth factors (FGFs) are key factors affecting diabetic wound healing. However, the FGF family’s expression patterns in skin...
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Umbilical cord mesenchymal stem cell-derived apoptotic extracellular vesicles ameliorate cutaneous wound healing in type 2 diabetic mice via macrophage pyroptosis inhibition
BackgroundDelayed healing of diabetic cutaneous wounds is one of the most common complications of type 2 diabetes mellitus (T2DM), which can bring...
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High glucose-induced IL-7/IL-7R upregulation of dermal fibroblasts inhibits angiogenesis in a paracrine way in delayed diabetic wound healing
It is widely acknowledged that diabetes leads to slow wound healing and ulceration, and severe serious diabetic foot ulceration may result in...
