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Genion, an accurate tool to detect gene fusion from long transcriptomics reads
BackgroundThe advent of next-generation sequencing technologies empowered a wide variety of transcriptomics studies. A widely studied topic is gene...
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Gene fusion as an important mechanism to generate new genes in the genus Oryza
BackgroundEvents of gene fusion have been reported in several organisms. However, the general role of gene fusion as part of new gene origination...
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Sex-Biased Transcription Expression of Vitellogenins Reveals Fusion Gene and MicroRNA Regulation in the Sea Louse Caligus rogercresseyi
The caligid ectoparasite, Caligus rogercresseyi , is one of the main concerns in the Chilean salmon industry. The molecular mechanisms displayed by...
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Fast and sensitive validation of fusion transcripts in whole-genome sequencing data
BackgroundIn cancer, genomic rearrangements can create fusion genes that either combine protein-coding sequences from two different partner genes or...
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A conventional PCR-based method to detect the E2 gene of the rubella virus for epidemiological analysis
To eliminate the rubella virus (RV), genetic characterization is vital for its detection, identification of endemic transmission, and diagnosis of...
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Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion
BackgroundViral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing...
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The inhibitory effect of rBCG on EB virus-positive tumours using an EB virus fusion gene
At present, studies have found that latent Epstein-Barr virus (EBV) infection is associated with a variety of human tumours, and a vaccine is not...
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Improved detection of clinically relevant fusion transcripts in cancer by machine learning classification
BackgroundGenomic rearrangements in cancer cells can create fusion genes that encode chimeric proteins or alter the expression of coding and...
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Bioinformatic Approaches for the Detection of Fusion Genes and trans-Splicing Products (A Review)
AbstractFusion genes and transcripts can be biological markers as well as the reasons for tumor progression and development. Modern algorithms and...
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Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish
Clinical sequencing efforts continue to identify novel putative oncogenes with limited strategies to perform functional validation in vivo and study...
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Cell Fusion and Syncytia Formation in Cancer
The natural phenomenon of cell–cell fusion does not only take place in physiological processes, such as placentation, myogenesis, or...
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Fusion Proteins Containing Proteorhodopsin from Exiguobacterium sibiricum
AbstractObjective: To study the transport activity of bacterial rhodopsins, proteoliposomes with the same orientation of the protein molecules...
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HMMF: a hybrid multi-modal fusion framework for predicting drug side effect frequencies
BackgroundThe identification of drug side effects plays a critical role in drug repositioning and drug screening. While clinical experiments yield...
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Modified fructan accumulation through overexpression of wheat fructan biosynthesis pathway fusion genes Ta1SST:Ta6SFT
BackgroundFructans are water-soluble carbohydrates that accumulate in wheat and are thought to contribute to a pool of stored carbon reserves used in...
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MFPINC: prediction of plant ncRNAs based on multi-source feature fusion
Non-coding RNAs (ncRNAs) are recognized as pivotal players in the regulation of essential physiological processes such as nutrient homeostasis,...
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M13 phage grafted with peptide motifs as a tool to detect amyloid-β oligomers in brain tissue
Oligomeric clusters of amyloid-β (Aβ) are one of the major biomarkers for Alzheimer’s disease (AD). However, proficient methods to detect...
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Genetic Analysis by Targeted Misexpression and Gene Silencing
Analysis of gene function is crucial for understanding the mechanism of biological processes. Critical clues to gene functions in vivo can be...
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M6PR interacts with the HA2 subunit of influenza A virus to facilitate the fusion of viral and endosomal membranes
Influenza A virus (IAV) commandeers numerous host cellular factors for successful replication. However, very few host factors have been revealed to...
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Dynamic evolution of the mTHF gene family associated with primary metabolism across life
BackgroundThe folate cycle of one-carbon (C1) metabolism, which plays a central role in the biosynthesis of nucleotides and amino acids, demonstrates...
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A comprehensive review of human trophoblast fusion models: recent developments and challenges
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast layer contributes to a successful pregnancy by secreting...
