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Development of GABAergic Inhibition Associated with Entorhinal Input in Granular Cells of the Dentate Gyrus
AbstractGranule cells (GC) in the dentate gyrus receive main excitatory input from the entorhinal cortex (EC) via the perforant pathway (PP). In...
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Abnormal chromatin remodeling caused by ARID1A deletion leads to malformation of the dentate gyrus
ARID1A, an SWI/SNF chromatin-remodeling gene, is commonly mutated in cancer and hypothesized to be a tumor suppressor. Recently, loss-of-function of...
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Neuronal progenitors of the dentate gyrus express the SARS-CoV-2 cell receptor during migration in the develo** human hippocampus
The COVID-19 pandemic spread around the world is due to the enormous capacity of the SARS-CoV-2 coronavirus to be transmitted between humans, causing...
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Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model
BackgroundImpaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis...
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Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
Children with attention-deficit/hyperactivity disorder (ADHD) often struggle with impaired executive function, temporal processing, and visuospatial...
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Pifithrin-α Inhibits Neural Differentiation of Newborn Cells in the Subgranular Zone of the Dentate Gyrus at Initial Stages of Audiogenic Kindling in Krushinsky–Molodkina Rat Strain
AbstractOne of the main challenges of modern neurobiology is finding approaches to prevent structural abnormalities in the brain, specifically, in...
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GSK-3β orchestrates the inhibitory innervation of adult-born dentate granule cells in vivo
Adult hippocampal neurogenesis enhances brain plasticity and contributes to the cognitive reserve during aging. Adult hippocampal neurogenesis is...
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Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV
Congenital hypothyroidism (CH), a common neonatal endocrine disorder, can result in cognitive deficits if delay in diagnose and treatment. Dentate...
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Ketamine’s rapid and sustained antidepressant effects are driven by distinct mechanisms
Administration of multiple subanesthetic doses of ketamine increases the duration of antidepressant effects relative to a single ketamine dose, but...
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Hippocampal subfield plasticity is associated with improved spatial memory
Physical exercise studies are generally underrepresented in young adulthood. Seventeen subjects were randomized into an intervention group...
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Structural Organization of the Rat Hippocampal Formation
AbstractThe review examines historical aspects of hippocampal nomenclature. His anatomical study began with the ancient Greeks, who named the...
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Dentate gyrus neurogenesis across different ages in male rats: an immunohistochemical approach
Dentate gyrus is a fundamental sub-region of the hippocampus which is directly engaged in higher memory and cognitive functions. This study was...
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NeuN distribution in brain structures of normal and Zika-infected suckling mice
Microcephaly is the more severe brain malformation because of Zika virus infection. Increased vulnerability of neural stem and progenitor cells to...
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Changes in the Rat Hippocampal Neurogenic Niche under Hypoxic Exposure
AbstractThe hippocampus is one of the brain structures most vulnerable to hypoxia. The cellular pool in the hippocampal subgranular zone (SGZ)...
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Early endocannabinoid-mediated depolarization-induced suppression of excitation delays the appearance of the epileptic phenotype in synapsin II knockout mice
The mechanism underlying the transition from the pre-symptomatic to the symptomatic state is a crucial aspect of epileptogenesis. SYN2 is a member of...
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Identification and functional characterization of CD133+GFAP+CD117+Sca1+ neural stem cells
Neural stem cells (NSCs) are responsible for maintaining the nervous system and repairing damages. Utility of NSCs could provide a novel solution to...
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Synchronized LFP rhythmicity in the social brain reflects the context of social encounters
Mammalian social behavior is highly context-sensitive. Yet, little is known about the mechanisms that modulate social behavior according to its...
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New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas
AbstractMemory formation is a complex process involving changes in the synaptic activity and gene expression encoding the insulin-like growth...
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Behavioral and Fluorescent-Based Immunohistochemistry Protocols for Examining Antidepressant-Like Effects of Melatonin in Mice
Antidepressants are characterized by their ability to decrease despair behavior assessed in mice as a decrease in immobility time in the forced...
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Resident Neural Stem Cell Niches and Regeneration: The Splendors and Miseries of Adult Neurogenesis
AbstractThe discovery of postnatal neurogenesis, the isolation and cultivation of neural stem cells (NSCs) in the adult brain, and the subsequent...
