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Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination
Human spermatogenesis is a highly ordered process; however, the roles of DNA methylation and chromatin accessibility in this process remain largely...
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Pathways of DNA Demethylation
The regulation of the genome relies on the overlying epigenome to instruct, define, and restrict the activities of cellular differentiation and...
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The role of DNA demethylation in liver to pancreas transdifferentiation
BackgroundInsulin producing cells generated by liver cell transdifferentiation, could serve as an attractive source for regenerative medicine. The...
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Iron drives anabolic metabolism through active histone demethylation and mTORC1
All eukaryotic cells require a minimal iron threshold to sustain anabolic metabolism. However, the mechanisms by which cells sense iron to regulate...
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Molecular basis of the plant ROS1-mediated active DNA demethylation
Active DNA demethylation plays a crucial role in eukaryotic gene imprinting and antagonizing DNA methylation. The plant-specific REPRESSOR OF...
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m1A demethylase Alkbh3 regulates neurogenesis through m1A demethylation of Mmp15 mRNA
BackgroundN 1 -Methyladenosine (m 1 A) is an abundant modification of transcripts regulating mRNA structure and translation efficiency. However, the...
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Advances in DNA methylation and demethylation in medicinal plants: a review
DNA methylation and demethylation are widely acknowledged epigenetic phenomena which can cause heritable and phenotypic changes in functional genes...
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Experimental DNA Demethylation Reduces Expression Plasticity and Thermal Tolerance in Pacific Oysters
Increasing seawater temperatures pose a great threat to marine organisms, especially those settled in fluctuating intertidal areas. DNA methylation,...
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Vitamin C activates young LINE-1 elements in mouse embryonic stem cells via H3K9me3 demethylation
BackgroundVitamin C (vitC) enhances the activity of 2-oxoglutarate-dependent dioxygenases, including TET enzymes, which catalyse DNA demethylation,...
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ALKBH5-mediated m6A demethylation of Runx2 mRNA promotes extracellular matrix degradation and intervertebral disc degeneration
BackgroundN6-methyladenosine (m 6 A) methylation is a prevalent RNA modification implicated in various diseases. However, its role in intervertebral...
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Exogenous proline regulates pectin demethylation by rescuing pectin methylesterase functioning of cell wall from Cr(VI) toxicity in rice plants
BackgroundPlants are equipped with several sophisticated mechanisms to deal with heavy metals (HMs) toxicity. Cell walls, which are rich in pectin,...
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Pectin demethylation-mediated cell wall Na+ retention positively regulates salt stress tolerance in oilseed rape
Key messageIntegrated phenomics, ionomics, genomics, transcriptomics, and functional analyses present novel insights into the role of pectin...
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Prediction of transcription factors associated with DNA demethylation during human cellular development
DNA methylation of CpG dinucleotides is an important epigenetic modification involved in the regulation of mammalian gene expression, with each type...
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The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
BackgroundEndometriosis cause decreases in life quality and pelvic pain in reproductive-age women. Methylation abnormalities played a functional role...
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Enzyme-free targeted DNA demethylation using CRISPR–dCas9-based steric hindrance to identify DNA methylation marks causal to altered gene expression
DNA methylation involves the enzymatic addition of a methyl group primarily to cytosine residues in DNA. This protocol describes how to produce...
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FTO-mediated m6A demethylation regulates GnRH expression in the hypothalamus via the PLCβ3/Ca2+/CAMK signalling pathway
N 6 -methyladenosine (m 6 A) plays a crucial role in the development and functional homeostasis of the central nervous system. The fat mass and...
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Profiling the Regulation of Histone Methylation and Demethylation by Metabolites and Metals
Here we describe how to profile the contribution of metabolism and implication of metals to histone methylation and demethylation. The techniques...
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Auto-suppression of Tet dioxygenases protects the mouse oocyte genome from oxidative demethylation
DNA cytosine methylation plays a vital role in repressing retrotransposons, and such derepression is linked with developmental failure, tumorigenesis...
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High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for diabetic cognitive dysfunction
Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in the development of diabetic cognitive dysfunction. N 6 -methyladen...
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Fbxo22 inhibits metastasis in triple-negative breast cancer through ubiquitin modification of KDM5A and regulation of H3K4me3 demethylation
The importance of Fbxo22 in carcinogenesis has been highly documented. Here, we discussed downstream regulatory factors of Fbxo22 in TNBC....
