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Neuroprotective Effects of Dehydroepiandrosterone and Hericium erinaceus in Scopolamine-induced Alzheimer’s Diseases-like Symptoms in Male Rats
BackgroundThe neuroprotective effects of Dehydroepiandrosterone (DHEA) and Hericium erinaceus (H . erinaceus ) mushroom extract against...
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Relationship between Dehydroepiandrosterone-Sulfate, Testosterone, Thyroid Hormones, Insulin, and Cortisol in Indigenous Men and Women among Representatives of the Indigenous and Newcomer Population of the Yamalo-Nenets Autonomous Okrug
AbstractUsing Spearman’s rank correlation we studied the correlations between the serum dehydroepiandrosterone-sulfate (DHEA-S) concentration and the...
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Sources and control of impurity during one-pot enzymatic production of dehydroepiandrosterone
AbstractDehydroepiandrosterone (DHEA) has a promising market due to its capacity to regulate human hormone levels as well as preventing and treating...
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Dehydroepiandrosterone exacerbates nigericin-induced abnormal autophagy and pyroptosis via GPER activation in LPS-primed macrophages
As a widely acknowledged FDA-approved dietary supplement or over-the-counter medicines, dehydroepiandrosterone (DHEA) exerts anti-inflammatory and...
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Circulating testosterone and dehydroepiandrosterone are associated with individual motor unit features in untrained and highly active older men
Long-term exercise training has been considered as an effective strategy to counteract age-related hormonal declines and minimise muscle atrophy....
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Hydroxylation of pregnenolone and dehydroepiandrosterone by zygomycete Backusella lamprospora VKM F-944: selective production of 7α-OH-DHEA
AbstractIn this paper, we studied the transformation of two 3β-hydroxy-5-ene-steroids—pregnenolone and dehydroepiandrosterone (DHEA) by Backusella...
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Validation of a Dehydroepiandrosterone-Sulfate Assay in Three Platyrrhine Primates (Alouatta caraya, Aotus azarae infulatus, and Sapajus apella)
The hormone dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are the most abundant circulating steroids in human and some nonhuman...
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Recombinant Extracellular Cholesterol Oxidase from Nocardioides simplex
AbstractCholesterol oxidase is a highly demanded enzyme used in medicine, pharmacy, agriculture, chemistry, and biotechnology. It catalyzes oxidation...
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Serum metabolomics study of narcolepsy type 1 based on ultra-performance liquid chromatography–tandem mass spectrometry
Narcolepsy is a chronic and underrecognized sleep disorder characterized by excessive daytime sleepiness and cataplexy. Furthermore, narcolepsy type...
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Synthesis, Structure, and Antitumor Activities of Dehydroepiandrosteronyl Derivatives with 1,2,3-Triazoles
AbstractObjective: Dehydroepiandrosterone plays an important role in the human beings due to its ability to be converted into androgens and...
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Functional characterization of variants in human ABCC11, an axillary osmidrosis risk factor
Human ATP-binding cassette transporter C11 (ABCC11) is a membrane protein exhibiting ATP-dependent transport activity for a variety of lipophilic...
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Selective Microbial Conversion of DHEA into 7α-OH-DHEA
7α-Hydroxy dehydroepiandrosterone (7α-OH-prasterone, 7α-OH-DHEA) is a key steroid intermediate in the synthesis of valuable pharmaceuticals widely...
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Сoncentration of Steriod Hormones and Ultrasonography of Pathologies of the Internal Organs of Females of the Siberian sturgeon Acipenser baerii (Acipenseridae) Reared at Constant Presence of Grower Feed and High Stocking Density
AbstractThe hormonal and ultrasound screening have been performed for the females of Siberian sturgeon Acipenser baerii reared under continuous...
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Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland
Adrenal glands, vital for steroid secretion and the regulation of metabolism, stress responses and immune activation, experience age-related decline,...
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Metabolomic characterization of vigor to frailty among community-dwelling older Black and White men and women
Older women and Black individuals are more likely to experience frailty. A metabolomic characterization of frailty may help inform more effective...
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Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging
In clinical trials, biochemical markers provide useful information on the drug’s mode of action, therapeutic response and side effect monitoring and...
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New insights into the treatment of polycystic ovary syndrome: HKDC1 promotes the growth of ovarian granulocyte cells by regulating mitochondrial function and glycolysis
Polycystic ovary syndrome (PCOS) is an endocrine disease, and its pathogenesis and treatment are still unclear. Hexokinase domain component 1 (HKDC1)...
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Modulation of the RAC1/MAPK/ERK signalling pathway by farnesyl diphosphate synthase regulates granulosa cells proliferation in polycystic ovary syndrome
Polycystic ovary syndrome (PCOS) is a complex gynaecological endocrine disease that occurs in women of childbearing age. The pathogenesis of PCOS is...
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Dehydroepiandrosterone Sulfate and Free Testosterone but not Estradiol are Related to Muscle Strength and Bone Microarchitecture in Older Adults
The study aimed to elucidate the relationship between sex steroids and muscle mass, muscle strength, and trabecular bone score (TBS) in a...
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Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p
BackgroundThe main features of polycystic ovary syndrome (PCOS) are abnormal follicular development and ovulatory dysfunction, which are caused by...
