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Screening of Key Genes in Retinoblastoma and Construction of ceRNA Regulatory Network
Retinoblastoma (RB) is an intraocular malignancy with a high incidence and very severe symptoms in children and is a rare life-threatening ophthalmic...
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A System Biology and Bioinformatics Approach to Determine the Molecular Signature, Core Ontologies, Functional Pathways, Drug Compounds in Between Stress and Type 2 Diabetes
Bioinformatics is the application of computer science and information technology to the field of biology and medicine. It involves the analysis of...
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Genome-Wide Identification and Validation of Target Genes Associated with Insecticide Treatment of the Green Peach Aphid, Myzus persicae
Next-generation sequencing and analyses of whole-genome transcripts can be used to identify genes and potential mechanisms that may be responsible...
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Medicine and Disease
This chapter deals with a selection of medical applications of bioinformatics, starting with genetically based diseases and the use of...
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Transcriptome Analysis of Different Aquaculture Substrates on the Immune Response of Babylonia areolata
To assess the impact of different substrates in a recirculating water system on the immune response and antioxidant capacity of Babylonia areolata ,...
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Application of GeneCloudOmics: Transcriptomic Data Analytics for Synthetic Biology
Research in synthetic biology and metabolic engineering require a deep understanding on the function and regulation of complex pathway genes. This...
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Uterine Cervix and Corpus Cancers Characterization Through Gene Expression Analysis Using the KnowSeq Tool
The characterization of cancer through gene expression quantification data analysis is a powerful and widely used approach in cancer research. This...
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Comparative Transcriptome Analysis Reveals the Light Spectra Affect the Growth and Molting of Scylla paramamosain by Changing the Chitin Metabolism
Light is an essential ecological factor that has been demonstrated to affect aquatic animals’ behavior, growth performance, and energy metabolism....
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Bioinformatics proved the existence of potential hub genes activating autophagy to participate in cartilage degeneration in osteonecrosis of the femoral head
The obvious degeneration of articular cartilage occurs in the late stage of osteonecrosis of the femoral head (ONFH), which aggravates the condition...
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Effects of Anthropogenic Chemicals on Hermatypic Corals with Special Reference to Gene Expression
Many studies have reported the adverse effects of various anthropogenic activities, including climate change and ocean acidification, on coral reefs....
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Metabolome and transcriptome analyses reveal changes of rapeseed in response to ABA signal during early seedling development
Seed germination is an important development process in plant growth. The phytohormone abscisic acid (ABA) plays a critical role during seed...
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Functional annotation and meta-analysis of maize transcriptomes reveal genes involved in biotic and abiotic stress
BackgroundEnvironmental stress factors, such as biotic and abiotic stress, are becoming more common due to climate variability, significantly...
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Transcriptome profiling of longissimus dorsi during different prenatal stages to identify genes involved in intramuscular fat deposition in lean and obese pig breeds
BackgroundThere was significant difference in muscle development between fat-type and lean-type pig breeds.
Methods and resultsIn current study,...
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Tumor immune microenvironment-based clusters in predicting prognosis and guiding immunotherapy in breast cancer
The development and progression of breast cancer (BC) depend heavily on the tumor microenvironment (TME), especially tumor infiltration leukocytes...
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Transcriptome Analysis Revealed the Differential Molecular Response Mechanisms of Roots, Stems, and Leaves in Mung Bean to Cadmium Stress
To acquire a comprehensive understanding of the different plant organ molecular mechanisms in response to cadmium (Cd), transcriptome analyses of...
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Transcriptomics analyses reveal the key genes involved in stamen petaloid formation in Alcea rosea L.
Alcea rosea L. is a traditional flower with a long cultivation history. It is extensively cultivated in China and is widely planted in green belt...
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Wheat TaAP2/ERF Genes Regulate Heat Tolerance Through Ethylene Signaling at Grain-Filling Stage
Wheat is a globally important crop, and its production is critically challenged by heat stress. To understand the heat tolerance mechanism at...
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Phenotypic divergence between broiler and layer chicken lines is regulated at the molecular level during development
BackgroundUnderstanding the molecular underpinnings of phenotypic variations is critical for enhancing poultry breeding programs. The Brazilian...
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Transcriptome analysis reveals various genes involved in the regulation of potato to late blight
BackgroundPotato ( Solanum tuberosum L. ) production is seriously threatened by the oomycete Phytophthora infestans ( P. infestans ). However, it...
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Transcriptome analysis of wild soybean (Glycine soja) in response to frogeye leaf spot caused by Cercospora so**a
Frogeye leaf spot (FLS), caused by Cercospora so**a , is a threat to soybean cultivation, leading to substantial economic losses. Here, an RNA...
