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FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis...
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Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Tectochrysin is a flavonoid...
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Liangyi Gao extends lifespan and exerts an antiaging effect in Caenorhabditis elegans by modulating DAF-16/FOXO
Liangyi Gao (LYG), a traditional Chinese medicine, is composed of Ginseng and Radix Rehmanniae Preparata, both of which have been shown to have...
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Bacterial vitamin B6 is required for post-embryonic development in C. elegans
Nutritional intake influences animal growth, reproductive capacity, and survival of animals. Under nutrition deficiency, animal developmental arrest...
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Lysosome-related organelles promote stress and immune responses in C. elegans
Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, their primordial functions remain...
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Regulation of the heat shock response by heat shock transcription factors
The heat shock response is characterized by a rapid and robust increase in heat shock proteins upon exposure to protein-damaging stresses. This...
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Bone morphogenetic protein signaling regulation of AMPK and PI3K in lung cancer cells and C. elegans
BackgroundBone morphogenetic protein (BMP) is a phylogenetically conserved signaling pathway required for development that is aberrantly expressed in...
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Forkhead box O proteins: steering the course of stem cell fate
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately...
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FOXO family isoforms
FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell...
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The role of serum-glucocorticoid regulated kinase 1 in reproductive viability: implications from prenatal programming and senescence
ObjectiveOrganisms and cellular viability are of paramount importance to living creatures. Disruption of the balance between cell survival and...
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Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans
BackgroundIn the nematode Caenorhabditis elegans , longevity in response to germline ablation, but not in response to reduced insulin/IGF1-like...
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Aryl hydrocarbon receptor (AhR) reveals evidence of antagonistic pleiotropy in the regulation of the aging process
The antagonistic pleiotropy hypothesis is a well-known evolutionary theory to explain the aging process. It proposes that while a particular gene may...
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A transcriptomic examination of encased rotifer embryos reveals the developmental trajectory leading to long-term dormancy; are they “animal seeds”?
BackgroundOrganisms from many distinct evolutionary lineages acquired the capacity to enter a dormant state in response to environmental conditions...
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Dauer juvenile recovery transcriptome of two contrasting EMS mutants of the entomopathogenic nematode Heterorhabditis bacteriophora
The entomopathogenic nematode Heterorhabditis bacteriophora , symbiotically associated with enterobacteria of the genus Photorhabdus , is a biological...
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Toxic stress-specific cytoprotective responses regulate learned behavioral decisions in C. elegans
BackgroundRecognition of stress and mobilization of adequate “fight-or-flight” responses is key for survival and health. Previous studies have shown...
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Lowbush cranberry acts through DAF-16/FOXO signaling to promote increased lifespan and axon branching in aging posterior touch receptor neurons
Medicinal berries are appreciated for their health benefits, in traditional ecological knowledge and nutrition science. Determining the cellular...
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Autophagy as a Promising Therapeutic Target in Age-Associated Neurodegenerative Disorders
Aging, and the reason for the process, has been an area of research where strides can improve the healthspan and lifespan of people all over the...
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MicroRNAs-associated with FOXO3 in cellular senescence and other stress responses
FOXO3 is a member of the FOXO transcription factor family and is known for regulating cellular survival in response to stress caused by various...
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Epigenetic Changes in Aging: The Contribution of SIRT1 to Longevity
Aging encompasses the gradual and intrinsic progression of physical, psychological, and functional changes that occur in living organisms over time....