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A cytosol-tethered YHB variant of phytochrome B retains photomorphogenic signaling activity
The red and far-red light photoreceptor phytochrome B (phyB) transmits light signals following cytosol-to-nuclear translocation to regulate...
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The effect of ionic redistributions on the microwave dielectric response of cytosol water upon glucose uptake
The sensitivity of cytosol water's microwave dielectric (MD) response to D-glucose uptake in Red Blood Cells (RBCs) allows the detailed study of...
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pH Changes in the Mitochondrial Matrix and Cytosol under Glutamate Deregulation of Ca2+ Homeostasis in Cultured Rat Hippocampal Neurons
AbstractThe effect of high concentrations of glutamate (Glu) on primary cultures of neurons from the rat brain led to a strong depolarization of...
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Cadmium-Responsive Expression and Activation of Cytosol-Localized Sugar Beet BvGSTU9 Associated with Cadmium Detoxification
Cadmium (Cd) pollution adversely affects the sustainable development of agriculture. Owing to its abundant biomass, strong adaptability and energy...
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Apoptotic priming is defined by the dynamic exchange of Bcl-2 proteins between mitochondria and cytosol
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer...
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Proteasome inhibition triggers the formation of TRAIL receptor 2 platforms for caspase-8 activation that accumulate in the cytosol
Cancer cells that are resistant to Bax/Bak-dependent intrinsic apoptosis can be eliminated by proteasome inhibition. Here, we show that proteasome...
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Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol
Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic...
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Cytosolic sorting platform complexes shuttle type III secretion system effectors to the injectisome in Yersinia enterocolitica
Bacteria use type III secretion injectisomes to inject effector proteins into eukaryotic target cells. Recruitment of effectors to the machinery and...
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Changes in Kinetic Parameters and Cytological Characteristics of Rooster Spermatozoa under the Influence of Technological Factors
AbstractThe problems of fertility reducing of rooster semen in the cycle “native sperm–equilibration–short-term and long-term storage...
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Cholera toxin: mechanisms of entry into host cells
Cholera toxin moves from the plasma membrane to the ER of host cells to cause disease. Trafficking in this pathway depends on toxin binding to...
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Genetic and evolutionary analyses of plastomes of the subfamily Cactoideae (Cactaceae) indicate relaxed protein biosynthesis and tRNA import from cytosol
Cactaceae arose ca. 30–35 million years ago (Mya) and comprises keystone species of arid and semiarid biomes. Various specific features related to...
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The intracellular interplay between galectin-1 and FGF12 in the assembly of ribosome biogenesis complex
Galectins constitute a class of lectins that specifically interact with β-galactoside sugars in glycoconjugates and are implicated in diverse...
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Biochemical Fractionation of Trypanosomes for the Analysis of Glycosomal Protein Import Defects
Insect-transmitted trypanosomatid parasite infections cause life-threatening neglected tropical diseases (NTDs), including African slee** sickness,...
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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into...
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GRminusRD: A Sensitive Assay to Detect Activation Processes at the Plasma Membrane in Living Cells
Activation processes at the plasma membrane have been studied with life-cell imaging using GFP fused to a protein that binds to a component of the...
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Fenton Reaction in vivo and in vitro. Possibilities and Limitations
AbstractThe review considers the problem of hydrogen peroxide decomposition and hydroxyl radical formation in the presence of iron in vivo and in vitro...
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Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells
Diphtheria toxin remains one of the most successfully studied of the bacterial protein toxins. A detailed understanding of the structure function...
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Proteasomal degradation of misfolded proteins
One of the most important functions of cellular quality control systems is to maintain structural fidelity of proteins. Molecular chaperones prevent...
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Diverse functions of cytochrome c in cell death and disease
The redox-active protein cytochrome c is a highly positively charged hemoglobin that regulates cell fate decisions of life and death. Under normal...
