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Mining and functional characterization of NADPH-cytochrome P450 reductases of the DNJ biosynthetic pathway in mulberry leaves
Background1-Deoxynojirimycin (DNJ), the main active ingredient in mulberry leaves, with wide applications in the medicine and food industries due to...
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Expression of Synthetic cyp102A1-LG23 Gene and Functional Analysis of Recombinant Cytochrome P450 BM3-LG23 in the Actinobacterium Mycolicibacterium smegmatis
AbstractCytochrome CYP102A1 (P450 BM3) of Priestia megaterium (bas. Bacillus megaterium ) has several unique functional features and thus provides an...
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Role of Cytochrome P450 in Xenobiotic Metabolism in Fishes (Review)
Cytochrome P450 (CYP) enzymes encompass a family of heme proteins which plays a prime role in the biotransformation of broad range of exogenous and...
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Cytochrome P450 for environmental remediation: catalytic mechanism, engineering strategies and future prospects
Environmental pollution is a global concern. Various organic compounds are released into the environment through wastewater, waste gas, and waste...
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Genome-wide identification, molecular evolution and gene expression of P450 gene family in Cyrtotrachelus buqueti
BackgroundInsect Cytochrome P450 monooxygenase ( CYPs or P450 s) plays an important role in detoxifying insecticides, causing insect populations to...
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Genome-wide identification, comparative analysis and functional roles in flavonoid biosynthesis of cytochrome P450 superfamily in pear (Pyrus spp.)
BackgroundThe cytochrome P450 (CYP) superfamily is the largest enzyme metabolism family in plants identified to date, and it is involved in many...
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Recent insights into function, structure and modification of cytochrome P450 153 a family
Cytochrome P450 153 A (CYP153A) is a versatile enzyme that can catalyze a wide range of oxidation reactions on various substrates. This review...
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Analysis of substrate specificity of cytochrome P450 monooxygenases involved in trichothecene toxin biosynthesis
Trichothecenes are a structurally diverse family of toxic secondary metabolites produced by certain species of multiple fungal genera. All...
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Overexpression of chaperones GroEL/ES from Escherichia coli enhances indigo biotransformation production of cytochrome P450 BM3 mutant
The self-sufficient cytochrome P450 BM3 mutant (A74G/F87V/D168H/L188Q) can serve as a biocatalyst for whole-cell catalysis process of indigo....
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The role of cytochrome P450 3A2 and 4V2 in response to high-temperature stress in Tetranychus truncatus (Acari: Tetranychidae)
Temperature is an important factor influencing the physiological activities of agricultural pests. Therefore, understanding pest physiological...
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The prevalence of pharmacogenetic variants of vitamin K epoxide reductase complex subunit 1 gene (rs9923231), cytochrome P450 family 2 subfamily C member 9 gene (rs1799853) and cytochrome P450 family 3 subfamily-A member-5 gene (rs776746) among 13 ethnic groups of Pakistan
BackgroundPharmacogenomics (PGx) plays a central role in the selection of targeted therapies that underpins precision-medicine. We investigated the...
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Establishment and characterization of cytochrome P450 1A1 CRISPR/Cas9 Knockout Bovine Foetal Hepatocyte Cell Line (BFH12)
The cytochrome P450 1A (CYP1A) subfamily of xenobiotic metabolizing enzymes (XMEs) consists of two different isoforms, namely CYP1A1 and CYP1A2 ,...
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Genome-wide analysis of the P450 gene family in tea plant (Camellia sinensis) reveals functional diversity in abiotic stress
BackgroundCytochrome P450 (Cytochrome P450s) genes are involved in the catalysis of various reactions, including growth, development, and secondary...
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Alteration of Hepatic Cytochrome P450 Expression and Arachidonic Acid Metabolism by Arsenic Trioxide (ATO) in C57BL/6 Mice
The success of arsenic trioxide (ATO) in acute promyelocytic leukemia has driven a plethora studies to investigate its efficacy in other...
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Ectopic expression of MmCYP1A1, a mouse cytochrome P450 gene, positively regulates stress tolerance in apple calli and Arabidopsis
Key messageEctopic expression of MmCYP1A1 gene from Mus musculus in apple calli and Arabidopsis increased the levels of melatonin and...
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Identification and characterization of cytochrome P450 CYP77A59 of loquat (Rhaphiolepis bibas) responsible for biosynthesis of phenylacetonitrile, a floral nitrile compound
Main conclusionCytochrome P450 CYP77A59 is responsible for the biosynthesis of phenylacetonitrile in loquat flowers.
AbstractFlowers of some plants...
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Computational identification and systematic classification of cytochrome P450 genes in Pogostemon cablin provide insights into flavonoids biosynthesis
Patchouli ( Pogostemon cablin (Blanco) Benth.) is a plant from the Lamiaceae family. Sesquiterpene hydrocarbons make up the majority of the patchouli...
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Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)
BackgroundMany drugs have the potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in...
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Delineation of the CYP505E subfamily of fungal self-sufficient in-chain hydroxylating cytochrome P450 monooxygenases
AbstractCytochrome P450 monooxygenases (CYP450s) are abundant in eukaryotes, specifically in plants and fungi where they play important roles in the...
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Response of P450 gene of Frankliniella occidentalis (Thysanoptera: Thripidae) in succession adaptation to broad bean plant
In insects, cytochrome P450 (CYP), an important detoxification enzyme, is crucial in host plant adaptation. In this study, we discerned the...
