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Explainable artificial intelligence-assisted virtual screening and bioinformatics approaches for effective bioactivity prediction of phenolic cyclooxygenase-2 (COX-2) inhibitors using PubChem molecular fingerprints
Cyclooxygenase-2 (COX-2) inhibitors are nonsteroidal anti-inflammatory drugs that treat inflammation, pain and fever. This study determined the...
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Mycobacterium marinum mediates regulation of prostaglandin E2 expression on host immune response through cyclooxygenase pathway
PurposeInvestigate the role of COX signaling in activating the PGE2-EP2 pathway.
MethodsUtilized a marine Mycobacterium infection model in...
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The Synthesis and Anti-inflammatory Studies of New Pyrimidine Derivatives, Inhibitors of Cyclooxygenase Isoforms
Abstract—Using the molecular docking approach the simulation of the complex formation of 17 uracil derivatives containing cyclic and acyclic sulfur-...
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The cyclooxygenase-expressing mesenchyme resists intestinal epithelial injury by paracrine signaling
Paracrine signals play pivotal roles in organ homeostasis. Mesenchymal stromal cells (MSCs) play a key role in regulating epithelium homeostasis in...
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Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values
BackgroundAutism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and...
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Fatty acid-binding protein 5 activates cyclooxygenase-2 and promotes hypoxic injury in LO2 cells
BackgroundHepatic hypoxia always results in liver inflammation and dysfunction. Fatty acid-binding protein 5 (FABP5) has been reported as a...
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Alpha-pinene modulates inflammatory response and protects against brain ischemia via inducible nitric oxide synthase-nuclear factor–kappa B-cyclooxygenase-2 pathway
BackgroundsCerebral ischemia-reperfusion leads to brain tissue injury. Inflammation and apoptosis play pivotal roles in the pathology.
...
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Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Blood Pressure and Hematological Indices in Rats
Abstract—The effect on blood pressure (BP), hematological indices, and body weight of rats was evaluated for nonselective cyclooxygenase (COX)...
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Design, Synthesis and Pharmacological Evaluation of Some 2-Methylsulfanyl-1,4-Dihydropyrimidines Derivatives as an Analgesic Agent
Abstract2-Methylsulfanyl-1,4-dihydropyrimidine derivatives were synthesized by alkylation of 1,2,3,4-tetrahydropyrimidines with methyl iodide in the...
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Effect of Cyclooxygenase Inhibitors Etoricoxib and Diclofenac Sodium and Their Combinations with Mexidol on Behavior in Rats
AbstractThe effect of nonsteroidal anti-inflammatory drugs (NSAIDs), selective cyclooxygenase (COX)-2 inhibitor etoricoxib and nonselective COX...
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Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases
Accumulating evidence suggests that endothelial cells can be useful therapeutic targets. One of the potential targets is an endothelial cell-specific...
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CFAP61 knockdown aggravates male infertility by inhibiting testosterone secretion by Leydig cells via the MAPK/COX-2 pathway
This study aimed to elucidate the roles of cilia- and flagella-associated protein 61 ( CFAP61 ) in male infertility and its underlying mechanisms. CFAP61 ...
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Evaluation of COX-2 production, anticancer efficacy against MCF-7 cell lines, and antioxidant activity of Garcinia conicarpa, a novel endemic species of the Western Ghats
Garcinia species are members of the Cluciaceae family and are rich in secondary metabolites. In the Western Ghats, Garcinia conicarpa is a recently...
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MUC16 facilitates cervical cancer progression via JAK2/STAT3 phosphorylation-mediated cyclooxygenase-2 expression
ObjectivesMUC16 (mucin 16, also known as CA-125, cancer antigen 125, carcinoma antigen 125, or carbohydrate antigen 125) has been predicted as tumor...
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Increased Serum Levels of Matrix-metalloproteinase-9, Cyclo-oxygenase-2 and Prostaglandin E-2 in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Chronic obstructive pulmonary disease (COPD), a heterogeneous lung disorder that is characterized by airflow obstruction and the third leading cause...
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Bovine Serum Albumin (BSA) Mediated Efficient One Pot Synthesis of 3,3′-(Phenylmethanediyl)bis(4-hydroxy-6-methyl-2H-pyran-2-one) Derivatives and Their Biological Studies
AbstractIn this work, biocatalysis was achieved by the synthesis of 3,3′-(phenylmethanediyl)bis(4-hydroxy6-methyl-2 H -pyran-2-one) derivatives ( IIIa–IIIh...
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TNF-α/IL-1β-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2/PGE2 pathway
BackgroundAdipose tissue-derived stem cell (ADSC) transplantation has been shown to be effective for the management of severe liver disorders....
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PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models
Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated...
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Prediction of the risk of develo** end-stage renal diseases in newly diagnosed type 2 diabetes mellitus using artificial intelligence algorithms
ObjectivesType 2 diabetes mellitus (T2DM) imposes a great burden on healthcare systems, and these patients experience higher long-term risks for...
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Arachidonic acid metabolism as a novel pathogenic factor in gastrointestinal cancers
Gastrointestinal (GI) cancers are a major global health burden, representing 20% of all cancer diagnoses and 22.5% of global cancer-related deaths....
