Search
Search Results
-
Sediment DNA Records the Critical Transition of Bacterial Communities in the Arid Lake
It is necessary to predict the critical transition of lake ecosystems due to their abrupt, non-linear effects on social-economic systems. Given the...
-
PI3K/AKT signaling pathway as a critical regulator of epithelial-mesenchymal transition in colorectal tumor cells
Colorectal cancer (CRC) is one of the most frequent gastrointestinal malignancies that are considered as a global health challenge. Despite many...
-
Data-driven energy landscape reveals critical genes in cancer progression
The evolution of cancer is a complex process characterized by stable states and transitions among them. Studying the dynamic evolution of cancer and...
-
System Biology Approach in Investigating Epithelial-Mesenchymal Transition (EMT)
Epithelial-mesenchymal transition (EMT) is a trans-differentiating and reversible process that leads to dramatic cell phenotypic changes, enabling...
-
CPMI: comprehensive neighborhood-based perturbed mutual information for identifying critical states of complex biological processes
BackgroundThere exists a critical transition or tip** point during the complex biological process. Such critical transition is usually accompanied...
-
Spatial transition tensor of single cells
Spatial transcriptomics and messenger RNA splicing encode extensive spatiotemporal information for cell states and transitions. The current...
-
Dynamic chromatin landscape encodes programs for perinatal transition of cardiomyocytes
The perinatal period occurring immediately before and after birth is critical for cardiomyocytes because they must change rapidly to accommodate the...
-
Critical scaling of whole-brain resting-state dynamics
Scale invariance is a characteristic of neural activity. How this property emerges from neural interactions remains a fundamental question. Here, we...
-
NF-κB signaling in neoplastic transition from epithelial to mesenchymal phenotype
NF-κB transcription factors are critical regulators of innate and adaptive immunity and major mediators of inflammatory signaling. The NF-κB...
-
Discordance between chromatin accessibility and transcriptional activity during the human primed-to-naïve pluripotency transition process
Naïve pluripotent state can be obtained by several strategies from various types of cells, in which the cell fate roadmap as well as key biological...
-
H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
BackgroundBivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of...
-
Identifying critical transitions in complex diseases
Mortality and the burden of diseases worldwide continue to reach substantial numbers with societal development and urbanization. In the face of...
-
Epigenetic modifications and miRNAs determine the transition of somatic cells into somatic embryos
Key messageThis review discusses the epigenetic changes during somatic embryo (SE) development, highlights the genes and miRNAs involved in the...
-
In Vivo Optogenetic Phase Transition of an Intrinsically Disordered Protein
Proteins containing intrinsically disordered regions (IDRs) control a wide variety of cellular processes by assembly of membrane-less organelles via...
-
Active layer dynamics drives a transition to biofilm fingering
The emergence of spatial organisation in biofilm growth is one of the most fundamental topics in biofilm biophysics and microbiology. It has long...
-
MIWE: detecting the critical states of complex biological systems by the mutual information weighted entropy
Complex biological systems often undergo sudden qualitative changes during their dynamic evolution. These critical transitions are typically...
-
From stationary to directional transition: a case study in Doñana
ContextDoñana’s landscape is a mosaic of different types of transitions at different spatial and temporal scales. Among them, stationary transitions...
-
Framework for conceptualising transition readiness from emergency response to rebuilding livelihoods in Mogadishu, Somalia
Emergency cash transfers provide essential life support to vulnerable households affected by a crisis, including those living in chronic poverty. So...
-
TGF-β/SMAD Pathway Mediates Cadmium Poisoning-Induced Chicken Liver Fibrosis and Epithelial-Mesenchymal Transition
Cadmium(Cd) is a toxic heavy metal widely present in the environment, capable of accumulating in the liver and causing liver damage. In this study,...
-
Epigenetic silencing of callose synthase by VIL1 promotes bud-growth transition in lily bulbs
In plants, restoring intercellular communication is required for cell activity in buds during the growth transition from slow to fast growth after...
