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Spatial and Temporal Localization of Connexins in Cells Using Confocal Microscopy
The 21-member connexin family found in humans is the building block of both single-membrane spanning channels (hemichannels) and double-membrane...
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The roles of connexins and gap junctions in the progression of cancer
Gap junctions (GJs), which are composed of connexins (Cxs), provide channels for direct information exchange between cells. Cx expression has a...
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Structure and Functions of Gap Junctions and Their Constituent Connexins in the Mammalian CNS
Abstract —Numerous data obtained in the last 20 years indicate that all parts of the mature central nervous system, from the retina and olfactory bulb...
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Expression and Function of Connexins in Extracellular Vesicles
Extracellular vesicles (EVs) are recognized as major vehicles for exchange of information across distant cells and tissues, which have been...
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Purification, Reconstitution, and Functional Analysis of Connexin Hemichannels
Connexins are the proteins that form the gap junction channels that are essential for cell-to-cell communication. These channels are formed by...
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Expression, Purification, and Nanodisc Reconstitution of Connexin-43 Hemichannels for Structural Characterization by Cryo-Electron Microscopy
Connexins are polytopic domain membrane proteins that form hexameric hemichannels (HCs) which can assemble into gap junction channels (GJCs) at the...
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Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket
BackgroundMembers of the β-subfamily of connexins contain an intracellular pocket surrounded by amino acid residues from the four transmembrane...
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Connexin 32 overexpression increases proliferation, reduces gap junctional intercellular communication, motility and epithelial-to-mesenchymal transition in Hs578T breast cancer cells
Connexins (Cx) are primary components of gap junctions that selectively allow molecules to be exchanged between adjacent cells, regulating multiple...
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Protocol for the Study of Connexin and DNA Interactions
Connexins (Cxs) are transmembrane proteins which form hemichannels and gap junction channels at the plasma membrane. These channels allow the...
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Novel and known variants in GJA3 and LIM2 in congenital cataract families from North India
BackgroundTo identify the underlying genetic defects in autosomal dominant (ADCC) and autosomal recessive (ARCC) congenital cataract families from...
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Mutation screening in autosomal dominant congenital cataract families from North India
Congenital cataract an opacity of the eye lens is present at birth and results in visual impairment during early childhood. If left untreated, it can...
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Cellular junction dynamics and Alzheimer’s disease: a comprehensive review
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder characterized by progressive neuronal damage and cognitive decline. Recent studies...
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Generation of Connexin-Expressing Stable Cell Pools
Stable cell pools have the advantage of providing a definite, consistent, and reproducible transmission of a transgene of interest, compared to...
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Are there gap junctions without connexins or pannexins?
BackgroundGap junctions (GJ) are one of the most common forms of intercellular communication. GJs are assembled from proteins that form channels...
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Connexin Hemichannels Methods and Protocols
This volume explores the latest developments in the study of connexin hemichannels (HCs). The chapters in this book cover topics such as...
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Phylogeny of teleost connexins reveals highly inconsistent intra- and interspecies use of nomenclature and misassemblies in recent teleost chromosome assemblies
BackgroundBased on an initial collecting of database sequences from the gap junction protein gene family (also called connexin genes) in a few...
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Molecular Dynamics Simulation of Permeation Through Connexin Channels
Molecular dynamics (MD) simulations are a collection of computational tools that can be used to trace intermolecular interactions at the...
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Desmosomes: emerging pathways and non-canonical functions in cardiac arrhythmias and disease
Desmosomes are critical adhesion structures in cardiomyocytes, with mutation/loss linked to the heritable cardiac disease, arrhythmogenic right...
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Assessment of Connexin43 Hemichannel Functionality Based on Cytosolic Uptake of Yo-Pro1
Connexin proteins are the building blocks of gap junctions and connexin hemichannels. Both provide a pathway for cellular communication. Gap...
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Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region
The atrioventricular canal (AVC) is the site where key structures responsible for functional division between heart regions are established, most...
