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X-Ray Crystallography to Study Conformational Changes in a TPP Riboswitch
Conformational rearrangements are key to the function of riboswitches. These regulatory mRNA regions specifically bind to cellular metabolites using...
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Enzymes, Conformational Changes, Energy, and Molecular Motors
There is a very important feature of molecule motion in water. Due to the extremely high viscosity of water in the molecule scale, the molecules have...
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Macromolecular conformational changes in photosystem II: interaction between structure and function
Conformational changes play an important role in the functioning of proteins and their complexes. This is also true for the pigment-protein...
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Proton transfer and conformational changes along the hydrogen bond network in heliorhodopsin
Heliorhodopsin releases a proton from the Schiff base during the L-state to M-state transition but not toward the protein bulk surface. Here we...
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Monitoring protein conformational changes using fluorescent nanoantennas
Understanding the relationship between protein structural dynamics and function is crucial for both basic research and biotechnology. However,...
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Conformational changes in the catalytic region are responsible for heat-induced activation of hyperthermophilic homoserine dehydrogenase
When overexpressed as an immature enzyme in the mesophilic bacterium Escherichia coli , recombinant homoserine dehydrogenase from the...
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Catalysis by Enzyme Conformational Change
An energy decomposition scheme is presented to elucidate the importance of the change of protein conformation substates to the reduction of...
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Spectral and conformational characteristics of phycocyanin associated with changes of medium pH
C-phycocyanin (C-PC) is the main component of water-soluble light-harvesting complexes (phycobilisomes, PBS) of cyanobacteria. PBS are involved in...
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Identifying Large Scale Conformational Changes in Proteins Through Distance Maps and Convolutional Networks
Conformational changes in protein structures are strongly correlated with functional changes. Some conformational modifications may be easily...
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Computational Study of Conformational Changes in Intrinsically Disordered Regions During Protein-Protein Complex Formation
Intrinsically Disordered Regions (IDRs) even though they cannot form a defined three-dimensional structure play a pivotal role in modulating cellular...
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Measuring Membrane Penetration Depths and Conformational Changes in Membrane Peptides and Proteins
AbstractThe structural organization and dynamic nature of the biomembrane components are important determinants for numerous cellular functions....
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ATP-dependent conformational dynamics in a photoactivated adenylate cyclase revealed by fluorescence spectroscopy and small-angle X-ray scattering
Structural insights into the photoactivated adenylate cyclases can be used to develop new ways of controlling cellular cyclic adenosine monophosphate...
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Combined NMR and molecular dynamics conformational filter identifies unambiguously dynamic ensembles of Dengue protease NS2B/NS3pro
The dengue protease NS2B/NS3pro has been reported to adopt either an ‘open’ or a ‘closed’ conformation. We have developed a conformational filter...
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Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that acidify intracellular compartments in eukaryotic cells. These multi-subunit complexes...
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Conformational ensemble-dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases
We studied diverse prenylated intrinsically disordered regions (PIDRs) of Ras and Rho family small GTPases using long timescale atomistic molecular...
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Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F1–Fo coupling
Mitochondrial adenosine triphosphate (ATP) synthase uses the proton gradient across the inner mitochondrial membrane to synthesize ATP. Structural...
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Regulation of Conformational Changes in C-reactive Protein Alters its Bioactivity
The acute phase C-reactive protein (CRP) is mainly synthesized and secreted by the liver in a cytokine-mediated response to infection or inflammation...
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Direct prediction of intrinsically disordered protein conformational properties from sequence
Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a range of functional roles. While folded domains are...
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Conformational buffering underlies functional selection in intrinsically disordered protein regions
Many disordered proteins conserve essential functions in the face of extensive sequence variation, making it challenging to identify the mechanisms...
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Direct experimental observation of blue-light-induced conformational change and intermolecular interactions of cryptochrome
Cryptochromes are blue light receptors that mediate circadian rhythm and magnetic sensing in various organisms. A typical cryptochrome consists of a...
