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Employing active learning in the optimization of culture medium for mammalian cells
Medium optimization is a crucial step during cell culture for biopharmaceutics and regenerative medicine; however, this step remains challenging, as...
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The STX17-SNAP47-VAMP7/VAMP8 complex is the default SNARE complex mediating autophagosome–lysosome fusion
Autophagosome–lysosome fusion mediated by SNARE complexes is an essential step in autophagy. Two SNAP29-containing SNARE complexes have been...
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Basic Fibroblast Growth Factor Accumulation in Culture Medium Masks the Direct Antitumor Effect of Anti-VEGF Agent Bevacizumab
AbstractThe direct antitumor effect of bevacizumab (BEV) has long been debated. Evidence of the direct antitumor activities of drugs are mainly...
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A review of electronic devices for tracking small and medium migratory shorebirds
Small- to medium-sized shorebirds (< 200 g) can be particularly difficult to track with electronic devices due to their small size and long-distance...
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An untargeted metabolomics approach to study changes of the medium during human cornea culture
IntroductionTwo main approaches (organ culture and hypothermia) for the preservation and storage of human donor corneas are globally adopted for...
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Buffer-free CAS assay using a diluted growth medium efficiently detects siderophore production and microbial growth
Siderophores are iron chelators and low-molecular-weight compounds secreted by various microorganisms under low-iron conditions. Many microorganisms...
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Guiding the HBO1 complex function through the JADE subunit
JADE is a core subunit of the HBO1 acetyltransferase complex that regulates developmental and epigenetic programs and promotes gene transcription....
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High-cell-density cultivation of Vibrio natriegens in a low-chloride chemically defined medium
AbstractVibrio natriegens is a halophilic bacterium with the fastest generation time of non-pathogenic bacteria reported so far. It therefore has...
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Modeling the Cryo-EM Structure of the Exocyst Complex
Multi-subunit tethering complexes (MTCs) are a family of evolutionarily conserved large protein complexes that function to tether intracellular...
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Structural insights into the iron nitrogenase complex
Nitrogenases are best known for catalyzing the reduction of dinitrogen to ammonia at a complex metallic cofactor. Recently, nitrogenases were shown...
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COX17 acetylation via MOF–KANSL complex promotes mitochondrial integrity and function
Reversible acetylation of mitochondrial proteins is a regulatory mechanism central to adaptive metabolic responses. Yet, how such functionally...
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Short-term adaptation as a tool to improve bioethanol production using grass press-juice as fermentation medium
AbstractGrass raw materials collected from grasslands cover more than 30% of Europe’s agricultural area. They are considered very attractive for the...
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Protein Profile of the Incubation Medium and Extract of Cestodes from the Intestines of Different Fish Species
AbstractThe protein composition of the incubation medium and extracts of different species of cestodes inhabiting the intestines of freshwater fish...
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Complex plasma research under microgravity conditions
The future of complex plasma research under microgravity condition, in particular on the International Space Station ISS, is discussed. First, the...
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Structure of histone deacetylase complex Rpd3S bound to nucleosome
Crosstalk between histone modifications represents a fundamental epigenetic mechanism in gene regulation. During the transcription elongation...
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Screening and optimisation of in vitro pollen germination medium for sweetpotato (Ipomoea batatas)
BackgroundSweetpotato is an important vegetable and food crop that is bred through sexual crosses and systematic selection. The use of in vitro...
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Structural organization of the retriever–CCC endosomal recycling complex
The recycling of membrane proteins from endosomes to the cell surface is vital for cell signaling and survival. Retriever, a trimeric complex of...
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Effect of environmental and microhabitat variables on tardigrade communities in a medium-sized city in central Argentina
Urban ecosystems are dynamic and complex, with human disturbances that lead to biotic homogenization. We consider the changes suffered by the...
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The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination
The BRCA1/BARD1 complex plays a key role in the repair of DNA double-strand breaks (DSBs) in both somatic cells and germ cells. However, the...
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Personalised modelling of clinical heterogeneity between medium-chain acyl-CoA dehydrogenase patients
BackgroundMonogenetic inborn errors of metabolism cause a wide phenotypic heterogeneity that may even differ between family members carrying the same...
