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An autonomous navigation method for orchard rows based on a combination of an improved a-star algorithm and SVR
Autonomous robot-based orchard operations will become an alternative solution in the field of precision agriculture. One of the keys to robotic work...
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An adaptive combination method for Cauchy variable based on optimal threshold
In sequence study, set-based analysis has been developed as a popular tool for analysing the association of a group rare variant with disease....
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Combination of a hierarchical and thermal shock process with a specific aqueous buffer: a safe, rapid and reliable DNA extraction method for plant endophytic fungi
This study aimed to investigate the utilization of a buffer solution, containing Tris, HCl, EDTA, NaCl, and glycerol (THENG), in combination with a...
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A new linear combination method of haplogroup distribution central vectors to model population admixtures
We introduce a novel population genetic approach suitable to model the origin and relationships of populations, using new computation methods...
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Harmonizing across datasets to improve the transferability of drug combination prediction
Combination treatment has multiple advantages over traditional monotherapy in clinics, thus becoming a target of interest for many high-throughput...
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EDST: a decision stump based ensemble algorithm for synergistic drug combination prediction
IntroductionThere are countless possibilities for drug combinations, which makes it expensive and time-consuming to rely solely on clinical trials to...
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Combination of Bifidobacterium breve and antibiotics against Clostridioides difficile: effect of the time interval of combination on antagonistic activity
Co-administration of probiotics and antibiotics has been used to prevent or treat primary Clostridioides difficile (pCDI), and the closer the...
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In-vitro susceptibility testing methods for the combination of ceftazidime-avibactam with aztreonam in metallobeta-lactamase producing organisms: Role of combination drugs in antibiotic resistance era
Resistance in Gram-negative organisms has become one of the leading threats in recent years. Of the different mechanisms described in the literature,...
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New high-density fermentation method for producing high molecular weight polysialic acid based on the combination fermentation strategy
AbstractPolysialic acid (PSA) is a long-chain linear amino polysaccharide with broad application prospects; however, its relatively low molecular...
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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by overcoming tumor cell immune...
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A network-based drug prioritization and combination analysis for the MEK5/ERK5 pathway in breast cancer
BackgroundPrioritizing candidate drugs based on genome-wide expression data is an emerging approach in systems pharmacology due to its holistic...
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Additivity predicts the efficacy of most approved combination therapies for advanced cancer
Most advanced cancers are treated with drug combinations. Rational design aims to identify synergistic combinations, but existing synergy metrics...
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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors
Combination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance...
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The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis
Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by...
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Estimating the optimal linear combination of predictors using spherically constrained optimization
BackgroundIn the context of a binary classification problem, the optimal linear combination of continuous predictors can be estimated by maximizing...
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Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
BackgroundDrug combination studies help to improve new treatment approaches for colon cancer. Tumor spheroids (3D) are better models than traditional...
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Tautomycin and enzalutamide combination yields synergistic effects on castration-resistant prostate cancer
The androgen receptor (AR) plays an essential role in prostate cancer progression and is a key target for prostate cancer treatment. However,...
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MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction
Drug combination therapy is generally more effective than monotherapy in the field of cancer treatment. However, screening for effective synergistic...
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A gene based combination test using GWAS summary data
BackgroundGene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in...
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Cell free extract-mediated biogenic synthesis of ZnONPs and their application with kanamycin as a bactericidal combination
Antimicrobial resistance (AMR) is a main public health issue and a challenge for the scientific community all over the globe. Hence, there is a...
