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Mechanisms, combination therapy, and biomarkers in cancer immunotherapy resistance
Anti-programmed death 1/programmed death ligand 1 (anti-PD-1/PD-L1) antibodies exert significant antitumor effects by overcoming tumor cell immune...
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Network-driven cancer cell avatars for combination discovery and biomarker identification for DNA damage response inhibitors
Combination therapy is well established as a key intervention strategy for cancer treatment, with the potential to overcome monotherapy resistance...
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Combination of Bifidobacterium breve and antibiotics against Clostridioides difficile: effect of the time interval of combination on antagonistic activity
Co-administration of probiotics and antibiotics has been used to prevent or treat primary Clostridioides difficile (pCDI), and the closer the...
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Investigating Combination Therapy as a Means to Enhance Activity and Repurpose Antimicrobials
Current clinical practice assumes that a single antibiotic given as a bolus or as a course will successfully treat most infections. In modern...
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Additivity predicts the efficacy of most approved combination therapies for advanced cancer
Most advanced cancers are treated with drug combinations. Rational design aims to identify synergistic combinations, but existing synergy metrics...
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Harmonizing across datasets to improve the transferability of drug combination prediction
Combination treatment has multiple advantages over traditional monotherapy in clinics, thus becoming a target of interest for many high-throughput...
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The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis
Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by...
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Apoptotic effect of 5-fluorouracil-doxorubicin combination on colorectal cancer cell monolayers and spheroids
BackgroundDrug combination studies help to improve new treatment approaches for colon cancer. Tumor spheroids (3D) are better models than traditional...
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Exploring the therapeutic potential of ADC combination for triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer. Currently, standard treatment options for TNBC are limited to...
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miR-28-based combination therapy impairs aggressive B cell lymphoma growth by rewiring DNA replication
Diffuse large B cell lymphoma (DLBCL) is the most common aggressive B cell lymphoma and accounts for nearly 40% of cases of B cell non-Hodgkin...
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MFSynDCP: multi-source feature collaborative interactive learning for drug combination synergy prediction
Drug combination therapy is generally more effective than monotherapy in the field of cancer treatment. However, screening for effective synergistic...
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Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells
Colon cancer is a major cause of cancer-related death. Despite recent improvements in the treatment of colon cancer, new strategies to improve the...
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Combination of Nisin and Glabridin Enhanced Apoptosis in Colorectal Cancer Cells
Nisin is an antimicrobial peptide (AMP) that is used as an approved food preservative. This peptide also acts as an anti-cancer agent inducing...
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EDST: a decision stump based ensemble algorithm for synergistic drug combination prediction
IntroductionThere are countless possibilities for drug combinations, which makes it expensive and time-consuming to rely solely on clinical trials to...
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In-vitro susceptibility testing methods for the combination of ceftazidime-avibactam with aztreonam in metallobeta-lactamase producing organisms: Role of combination drugs in antibiotic resistance era
Resistance in Gram-negative organisms has become one of the leading threats in recent years. Of the different mechanisms described in the literature,...
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Metformin and adipose-derived stem cell combination therapy alleviates radiation-induced skin fibrosis in mice
BackgroundRadiation therapy often leads to late radiation-induced skin fibrosis (RISF), causing movement impairment and discomfort. We conducted a...
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The use of combination therapy for the improvement of colistin activity against bacterial biofilm
Colistin is used as a last resort for the management of infections caused by multi-drug resistant (MDR) bacteria. However, the use of this antibiotic...
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Enhancement of targeted therapy in combination with metformin on human breast cancer cell lines
BackgroundBreast cancer remains a primary global health concern due to its limited treatment options, frequent disease recurrence, and high rates of...
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The path to next-generation disease-modifying immunomodulatory combination therapies in Alzheimer’s disease
The cautious optimism following recent anti-amyloid therapeutic trials for Alzheimer’s disease (AD) provides a glimmer of hope after years of...
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Dose–response prediction for in-vitro drug combination datasets: a probabilistic approach
In this paper we propose PIICM, a probabilistic framework for dose–response prediction in high-throughput drug combination datasets. PIICM utilizes a...
