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1. In Vitro Porcine (Explant) Colon Culture

   Models have been extensively used to investigate disease pathogenesis. Animal models are costly and require extensive logistics for animal care, and...

   Matheus de Oliveira Costa, Michael K. Dame in Epithelial Cell Culture

   Protocol 2024
   

2. Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer

   The human intestine is a habitat for microorganisms and, recently, the composition of the intestinal microbiota has been correlated with the etiology...

   Ceren Acar, Sibel Kucukyildirim Celik, ... Hatice Mergen in Folia Microbiologica

   Article 22 June 2023
   

3. Proteomic analysis of low- and high-grade human colon adenocarcinoma tissues and tissue-derived primary cell lines reveals unique biological functions of tumours and new protein biomarker candidates

   Background

   Colon cancer is the third most common cancer and second highest cause of cancer deaths worldwide. The aim of the study was to find new...

   Matthew J. Munro, Susrutha K. Wickremesekera, ... Lifeng Peng in Clinical Proteomics

   Article Open access 16 July 2022
   

4. Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury

   Abstract

   Obstructive sleep apnea (OSA) can lead to intestinal injury, endotoxemia, and disturbance of intestinal flora. Additionally, as a crucial...

   Pei-Pei Wang, **ao-Qian Cheng, ... Bei Wang in Applied Microbiology and Biotechnology

   Article Open access 18 June 2024
   

5. Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells

   Drug resistance represents a major problem in cancer treatment. Doxorubicin (adriamycin) is an injectable DNA intercalating drug that halts cancer...

   Himani Shah, Timothy A. Hill, ... David P. Fairlie in Journal of Cell Communication and Signaling

   Article 22 November 2023
   

6. A Comparative Systematic Analysis of The Influence of Microplastics on Colon Cells, Mouse and Colon Organoids

   Background:

   Microplastics (MPs) are small fragments from any type of plastic formed from various sources, including plastic waste and microfibers from...

   Sung Bum Park, Won Hoon Jung, ... Ki Young Kim in Tissue Engineering and Regenerative Medicine

   Article 14 November 2022
   

7. An integrated map of fibroblastic populations in human colon mucosa and cancer tissues

   Fibroblasts and myofibroblasts are major mesenchymal cells in the lamina propria of colon mucosa and in colon cancer tissues. Detailed insight into...

   Siying Li, Ran Lu, ... **anming Mo in Communications Biology

   Article Open access 03 December 2022
   

8. Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids

   Understanding the mechanisms involved in colonic epithelial differentiation is key to unraveling the alterations causing inflammatory conditions and...

   Pilar Bustamante-Madrid, Antonio Barbáchano, ... Asunción Fernández-Barral in Cell Death & Disease

   Article Open access 29 April 2024
   

9. Tumor derived exosomal ENTPD2 impair CD8⁺ T cell function in colon cancer through ATP-adenosine metabolism reprogramming

   Background

   Extracellular ATP–AMP–adenosine metabolism plays a pivotal role in modulating tumor immune responses. Previous studies have shown that the...

   Mengchen Shi, Linsen Ye, ... Zihuan Yang in Cell Communication and Signaling

   Article Open access 16 May 2024
   

10. Understanding Colon Cancer: Causes, Prevention, and Complementary Therapies Including Therapeutic Foods, Beverages, and Meditation

    Colon cancer is a significant health concern globally, and understanding its biology, causes, prevention, and complementary therapies is crucial for...

    Mahalakshmi S. Biradar, Shankar Thapa, ... Kalusing S. Padvi in Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases

    Chapter 2024
    

11. ILC1-derived IFN-γ regulates macrophage activation in colon cancer

    Background

    Tumor-associated macrophages (TAMs) are an important subset of innate immune cells in the tumor microenvironment, and they are pivotal...

    Yandong Zhang, Shu Ma, ... Lan Huang in Biology Direct

    Article Open access 07 September 2023
    

12. Role of Gut Microbiota in Predisposition to Colon Cancer: A Narrative Review

    Globally, colorectal cancer (CRC) is a leading cause of cancer-related mortality. Dietary habits, inflammation, hereditary characteristics, and gut...

    Hattiangadi Shruthi Kamath, Rushikesh Shukla, ... Dibyankita Ghosh in Indian Journal of Microbiology

    Article 29 March 2024
    

13. Bacteria colonization and gene expression related to immune function in colon mucosa is associated with growth in neonatal calves regardless of live yeast supplementation

    Background

    As Holstein calves are susceptible to gastrointestinal disorders during the first week of life, understanding how intestinal immune...

    Koki Nishihara, Clothilde Villot, ... Michael Steele in Journal of Animal Science and Biotechnology

    Article Open access 05 June 2024
    

14. Mutant p53 gain-of-function stimulates canonical Wnt signaling via PI3K/AKT pathway in colon cancer

    Aberrant canonical Wnt signaling is a hallmark of colon cancer. The TP53 tumor suppressor gene is altered in many solid tumors, including colorectal...

    Eduardo Alvarado-Ortiz, Elizabeth Ortiz-Sánchez, ... Martha Robles-Flores in Journal of Cell Communication and Signaling

    Article Open access 20 November 2023
    

15. Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon

    Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we...

    Carl-Gustaf A. Stenvall, Mina Tayyab, ... Diana M. Toivola in Cellular and Molecular Life Sciences

    Article Open access 24 December 2021
    

16. Transient receptor potential channel stimulation induced oxidative stress and apoptosis in the colon of mice with colitis-associated colon cancer: modulator role of Sambucus ebulus L.

    Background

    Increased Ca ²⁺ entry causes an increase in tumor cell proliferation, apoptosis, cytosolic reactive free oxygen species (cyROS), and...

    Müge Mavioğlu Kaya, İnan Kaya, Mustafa Nazıroğlu in Molecular Biology Reports

    Article 24 December 2022
    

17. P4HA3 promotes colon cancer cell escape from macrophage phagocytosis by increasing phagocytosis immune checkpoint CD47 expression

    Cancer immunotherapies have greatly changed the prospects for the therapy of many malignancies, including colon cancer. Macrophages as the effectors...

    Hailang Zhou, Junwei Zou, ... Shu Huang in Molecular and Cellular Biochemistry

    Article 12 February 2024
    

18. Identification of two migratory colon ILC2 populations differentially expressing IL-17A and IL-5/IL-13

    Group 2 innate lymphoid cells (ILC2s) play important tissue resident roles in anti-parasite immunity, allergic immune response, tissue homeostasis,...

    Hongzhi Liu, Liang Li, ... Bing Su in Science China Life Sciences

    Article 22 July 2022

19. PRMT1 reverts the immune escape of necroptotic colon cancer through RIP3 methylation

    Necroptosis plays a double-edged sword role in necroptotic cancer cell death and tumor immune escape. How cancer orchestrates necroptosis with immune...

    Lian Zhang, Yujiao He, ... Guoxiang ** in Cell Death & Disease

    Article Open access 01 April 2023
    

20. Negative regulation of HDAC3 transcription by histone acetyltransferase TIP60 in colon cancer

    Background

    Colon cancer is the third most common cancer globally. The expression of histone deacetylase 3 ( HDAC3 ) is upregulated, whereas the...

    Seong Yun Lee, Junyoung Park, Sang Beom Seo in Genes & Genomics

    Article Open access 28 May 2024