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Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity
Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the...
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Peripheral T-cell responses of EphB2- and EphB3-deficient mice in a model of collagen-induced arthritis
Both EphB2- and EphB3-deficient mice exhibit profound histological alterations in the thymic epithelial network but few changes in T-cell...
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Morin, the PPARγ agonist, inhibits Th17 differentiation by limiting fatty acid synthesis in collagen-induced arthritis
T helper (Th) 17 cells highly contribute to the immunopathology of rheumatoid arthritis. Morin, a natural flavonoid, owns well anti-arthritic action...
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Therapeutic effect of intra-articular injected 3′-sialyllactose on a minipig model of rheumatoid arthritis induced by collagen
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease of joint, but there is no known cure.
3′-sialyllactose (3′-SL) is an...
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Variation of sexual dimorphism and asymmetry in disease expression of inflammatory arthritis among laboratory mouse models with different genomic backgrounds
Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse...
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Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway
Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to disability. Inflammatory cell infiltration, severe joint...
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Angiotensin-(1–7) attenuates collagen-induced arthritis via inhibiting oxidative stress in rats
The present study was designed to investigate the anti-rheumatic effects and the mechanism of angiotensin (Ang)-(1–7) in rat models with...
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Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Ethanol consumption has been reported to reduce morbidity in RA patients, but the...
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Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Rheumatoid arthritis (RA) is an autoimmune disease that causes joint swelling and inflammation and can involve the entire body. RA is characterized...
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Role of Herbal Medicines for the Treatment of Arthritis
The use of herbal medicines has extensively propagated in almost every country worldwide and also in developed countries. Nowadays, various herbal...
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IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease with an unknown etiology. RA cannot be fully cured and requires lengthy treatment, imposing...
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Exosomes derived from mesenchymal stem cells primed with disease-condition-serum improved therapeutic efficacy in a mouse rheumatoid arthritis model via enhanced TGF-β1 production
BackgroundsRheumatoid arthritis (RA) is a chronic and systemic autoimmune disease characterized by synovial inflammation-mediated progressive...
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MiR-326 regulates cell proliferation and apoptosis in fibroblast-like synoviocytes in rheumatoid arthritis
The dysregulation of microRNAs plays a critical role in the development of rheumatoid arthritis (RA). This study aims to explore the functional...
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Mechanistic Approaches of Herbal Medicine in the Treatment of Arthritis
Arthritis is a global concern, affecting the global population, especially older people. The allopathic treatments proved their efficacy but...
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Mechanistic Approaches of Herbal Medicine in the Treatment of Arthritis
Arthritis is a global concern, affecting the global population, especially older people. The allopathic treatments proved their efficacy but...
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Pharmacological and immunomodulatory modes of action of medically important phytochemicals against arthritis: A molecular insight
Arthritis is a common illness that affects joints and it may result in inflammation and pain. Even though arthritis usually affects older people, it...
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SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis
BackgroundCoronavirus disease 2019 (COVID-19) induces inflammation, autoantibody production, and thrombosis, which are common symptoms of autoimmune...
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A novel mechanism for macrophage pyroptosis in rheumatoid arthritis induced by Pol β deficiency
Rheumatoid arthritis (RA) is a chronic and inflammatory autoimmune disease. Macrophage pyroptosis, a proinflammatory form of cell death, is...
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Two major genes associated with autoimmune arthritis, Ncf1 and Fcgr2b, additively protect mice by strengthening T cell tolerance
A breach of T cell tolerance is considered as a major step in the pathogenesis of rheumatoid arthritis. In collagen-induced arthritis (CIA) model,...
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SMOC2 promotes aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis through transcriptional and post-transcriptional regulating MYO1C
Fibroblast-like synoviocytes (FLSs), play a key role in perpetuating synovial inflammation and bone erosion in rheumatoid arthritis (RA), however,...
