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Co-transcriptional gene regulation in eukaryotes and prokaryotes
Many steps of RNA processing occur during transcription by RNA polymerases. Co-transcriptional activities are deemed commonplace in prokaryotes, in...
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Epigenetic Regulation in Response to CO2 Fluctuation in Marine Microalga Nannochloropsis oceanica
Microalgae often undergo different CO 2 experiment in their habitat. To adapt to low CO 2 , carbon concentrating mechanism (CCM) could be launched in...
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Evidence for the role of transcription factors in the co-transcriptional regulation of intron retention
BackgroundAlternative splicing is a widespread regulatory phenomenon that enables a single gene to produce multiple transcripts. Among the different...
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Exploring cell-specific miRNA regulation with single-cell miRNA-mRNA co-sequencing data
BackgroundExisting computational methods for studying miRNA regulation are mostly based on bulk miRNA and mRNA expression data. However, bulk data...
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Integrated modeling framework reveals co-regulation of transcription factors, miRNAs and lncRNAs on cardiac developmental dynamics
AimsDissecting complex interactions among transcription factors (TFs), microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are central for...
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Co-effects of m6A and chromatin accessibility dynamics in the regulation of cardiomyocyte differentiation
BackgroundCardiomyocyte growth and differentiation rely on precise gene expression regulation, with epigenetic modifications emerging as key players...
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Systematic assessment of gene co-regulation within chromatin domains determines differentially active domains across human cancers
BackgroundSpatial interactions and insulation of chromatin regions are associated with transcriptional regulation. Domains of frequent chromatin...
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Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression
BRAF mutations have been found in gliomas which exhibit abnormal electrophysiological activities, implying their potential links with the ion channel...
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Regulation of nutrient use efficiency: Boon to wheat cultivar under co-impact of drought and arsenic
Background and aimsMeasurement of Nutrient use efficiency (NUE) can be useful for evaluating crops under stressful conditions. The study aimed to...
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The Role of Epigenetic Communication in the Co-regulation of Holobionts’ Biology: Interspecies Probabilistic Epigenesis
Current fast-paced advances in molecular biology, microbiology, and developmental biology mean a true revolution to how we see organism ecology and...
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Long non-coding RNAs: an overview on miRNA sponging and its co-regulation in lung cancer
Lung cancer is the most devastating cause of death among all cancers worldwide, and non-small cell lung cancer (NSCLC) accounts for 80% of all the...
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Shared regulation and functional relevance of local gene co-expression revealed by single cell analysis
Most human genes are co-expressed with a nearby gene. Previous studies have revealed this local gene co-expression to be widespread across...
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Analysis of RBP Regulation and Co-regulation of mRNA 3′ UTR Regions in a Luciferase Reporter System
The luciferase reporter assay is a widely used tool to study the cis and trans factors controlling regulation of gene expression. In this assay,...
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Efficient co-production of EPA and DHA by Schizochytrium sp. via regulation of the polyketide synthase pathway
Presently, the supply of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) traditionally produced by marine fisheries will be insufficient...
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Co-expression Networks in Predicting Transcriptional Gene Regulation
Recent progress in transcriptomics and co-expression networks have enabled us to predict the inference of the biological functions of genes with the...
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Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata
Breathing is highly sensitive to the PCO 2 of arterial blood. Although CO 2 is detected via the proxy of pH, CO 2 acting directly via Cx26 may also...
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Exploring the complexity of soybean (Glycine max) transcriptional regulation using global gene co-expression networks
Main conclusionWe report a soybean gene co-expression network built with data from 1284 RNA-Seq experiments, which was used to identify important...
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Gene Co-expression Network Analysis to Mine Genes Involved in Plant Secondary Metabolite Biosynthesis and Regulation
Plants produce diverse specialized metabolites (SMs) that do not participate in plant growth and development but help them adapt to various...