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Bone Turnover Markers in Children: From Laboratory Challenges to Clinical Interpretation
Bone turnover markers (BTMs) have been developed many years ago to study, in combination with imaging techniques, bone remodeling in adults. In...
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The effect of crocin-selenium nanoparticles on the cognition and oxidative stress markers of multiple sclerosis patients: a randomized triple-blinded placebo-controlled clinical trial
The prevalence of cognitive impairment in multiple sclerosis (MS) patients is estimated to be approximately 40–60%. There is an increasing body of...
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Practical Considerations for the Clinical Application of Bone Turnover Markers in Osteoporosis
Bone turnover markers (BTMs) are released during the bone remodelling cycle and are measurable in blood or urine, reflecting bone remodelling rate....
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Biochemical Markers of Musculoskeletal Health and Aging to be Assessed in Clinical Trials of Drugs Aiming at the Treatment of Sarcopenia: Consensus Paper from an Expert Group Meeting Organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the Centre Académique de Recherche et d'Expérimentation en Santé (CARES SPRL), Under the Auspices of the World Health Organization Collaborating Center for the Epidemiology of Musculoskeletal Conditions and Aging
In clinical trials, biochemical markers provide useful information on the drug’s mode of action, therapeutic response and side effect monitoring and...
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Markers of imminent myocardial infarction
Myocardial infarction is a leading cause of death globally but is notoriously difficult to predict. We aimed to identify biomarkers of an imminent...
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Multikingdom and functional gut microbiota markers for autism spectrum disorder
Associations between the gut microbiome and autism spectrum disorder (ASD) have been investigated although most studies have focused on the bacterial...
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Research progress of good markers for canine mammary carcinoma
PurposeMammary gland tumors are the most common neoplastic diseases in elderly female dogs, about 50% of which are considered to be malignant. Canine...
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Proteomic Markers and Early Prediction of Alzheimer’s Disease
AbstractAlzheimer’s disease (AD) is the most common socially significant neurodegenerative pathology, which currently affects more than 30 million...
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Principal component-based clinical aging clocks identify signatures of healthy aging and targets for clinical intervention
Clocks that measure biological age should predict all-cause mortality and give rise to actionable insights to promote healthy aging. Here we applied...
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Lipid Markers for Marine Organic Matter
An astonishing variety of different lipids have been found in marine sediments and the water column attesting to the diversity of biosynthetic...
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Dynamic Changes in the Immune Status and Biochemical Blood Markers in Patients after Cardiac Surgery with Cardiopulmonary Bypass
AbstractA general nonspecific adaptive reaction, stress develo** during the sequential implementation of the stages “anxiety,” “resistance,” and...
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Association between inflammatory markers, body composition and frailty in home-dwelling elderly: an 8-year follow-up study
Frailty has been linked to inflammation and changes in body composition, but the findings are inconsistent. To explore this, we used the Frailty...
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Single-cell lineage tracing with endogenous markers
Resolving lineage relationships between cells in an organism provides key insights into the fate of individual cells and drives a fundamental...
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Laboratory Markers of Platelet Production and Turnover
AbstractPlatelets are formed from bone marrow megakaryocytes, circulate in blood for 7-10 days, and then are destroyed in the spleen and/or liver....
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Biochemical Markers of Zinc Nutrition
Zinc is an important trace element involved in the biochemical and physiological functions of the organism and is essential in the human body. It has...
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Multi-omics and Its Clinical Application
With the rise of the severity of diseases the need to devise a predictive mechanism that ensures early and precise detection has increased. To...
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In Silico Clinical Trials: Is It Possible?
Modeling and simulation (M&S), including in silico (clinical) trials, helps accelerate drug research and development and reduce costs and have coined...
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Using Artificial Intelligence to Interpret Clinical Flow Cytometry Datasets for Automated Disease Diagnosis and/or Monitoring
Flow cytometry (FC) is routinely used for hematological disease diagnosis and monitoring. Advancement in this technology allows us to measure an...
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Analysis of Neutrophil and Monocyte Inflammation Markers in Response to Gram-Positive Anaerobic Cocci
The impact of anaerobic bacteria on the human host is sparsely investigated due to cultivation challenges. Nonetheless, in the last decade increasing...