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Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors
BackgroundIn most parts of the world, especially in underdeveloped countries, acquired immunodeficiency syndrome (AIDS) still remains a major cause...
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Selection of an Amino Acid Site with One of the Fastest Cleavage Kinetics by the Endosomal Protease Cathepsin B for Potential Use in Drug Delivery Systems
AbstractOn the basis of known published data, six peptide sequences were selected that are potentially capable of being rapidly cleaved by the...
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Ischemia-induced cleavage of OPA1 at S1 site aggravates mitochondrial fragmentation and reperfusion injury in neurons
Neuronal mitochondrial dynamics are disturbed after ischemic stroke. Optic atrophy 1 (OPA1) and its GTPase activity are involved in maintaining...
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DiCleave: a deep learning model for predicting human Dicer cleavage sites
BackgroundMicroRNAs (miRNAs) are a class of non-coding RNAs that play a pivotal role as gene expression regulators. These miRNAs are typically...
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RIPK3 cleavage is dispensable for necroptosis inhibition but restricts NLRP3 inflammasome activation
Caspase-8 activity is required to inhibit necroptosis during embryogenesis in mice. In vitro studies have suggested that caspase-8 directly cleaves...
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A DNA Cleavage Assay Using Synthetic Oligonucleotide Containing a Single Site-Directed Lesion for In Vitro Base Excision Repair Study
Many chemicals cause mutation or cancer in animals and humans by forming DNA lesions, including base adducts, which play a critical role in...
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Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis
The proteolytic activity of caspase-8 suppresses lethal RIPK1-, RIPK3- and MLKL-dependent necroptosis during mouse embryogenesis. Caspase-8 is...
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Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage
GSDMB is associated with several inflammatory diseases, such as asthma, sepsis and colitis. GZMA is released by cytotoxic lymphocytes and cleaves...
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Expression and purification of epinecidin-1 variant (Ac-Var-1) by acid cleavage
AbstractThe demand for massive quantities of therapeutic active antimicrobial peptides (AMPs) is high due to their potential as alternatives to...
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Peptide Backbone Modifications for the Assessment of Cleavage Site Relevance in Precursors of Signaling Peptides
The physiological relevance of site-specific precursor processingPrecursor processing for the biogenesis of peptide hormones and growth factors can...
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The high mutation rate at the D614G hotspot-furin cleavage site region increases the priming efficiency of the Spike protein by furin protease: analysis of Indonesian SARS-CoV-2 G614 variants obtained during the early COVID-19 pandemic
D614G mutation plays a significant role in the transmissibility of SARS-CoV-2. Identification of other mutations related to D614G mutation within the...
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Relaxed Cleavage Specificity of Hyperactive Variants of Escherichia coli RNase E on RNA I
RNase E is an essential enzyme in Escherichia coli . The cleavage site of this single-stranded specific endoribonuclease is well-characterized in many...
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Full-length GSDME mediates pyroptosis independent from cleavage
Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here...
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Manipulation of Embryonic Cleavage Geometry Using Magnetic Tweezers
The geometry of reductive divisions that mark the development of early embryos instructs cell fates, sizes, and positions, by mechanisms that remain...
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PTBP1 protects Y RNA from cleavage leading to its apoptosis-specific degradation
Some RNAs such as 28S rRNA, U1 small nuclear RNA (snRNA), and Y RNAs are known to be cleaved during apoptosis. The underlying mechanism, functions,...
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Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage
Gasdermin B (GSDMB) and gasdermin E (GSDME) are two members of the gasdermin family, which shares a conservative gasdermin-N domain capable of...
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The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and the S2ʹ cleavage sites to mediate membrane fusion....
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Precise DNA cleavage using CRISPR-SpRYgests
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave DNA directly adjacent to bases of interest. Restriction...
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Control of mammalian gene expression by modulation of polyA signal cleavage at 5′ UTR
The ability to control gene expression in mammalian cells is crucial for safe and efficacious gene therapies and for elucidating gene functions....
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Cleavage of natural rubber by rubber oxygenases in Gram-negative bacteria
AbstractBacterial degradation of natural rubber (NR) in an oxic environment is initiated by oxidative cleavage of double bonds in the NR-carbon...
