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The Caspase-Activated DNase drives inflammation and contributes to defense against viral infection
Mitochondria react to infection with sub-lethal signals in the apoptosis pathway. Mitochondrial signals can be inflammatory but mechanisms are only...
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Unusual serological profile in hepatitis B virus (HBV) infection associated with a probable clinical case of acute exacerbation of pre-existing chronic HBV infection
BackgroundAcute or chronic HBV infection in an individual can be laboratory characterized according to the serological profile of the viral markers...
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A necroptosis-independent function of RIPK3 promotes immune dysfunction and prevents control of chronic LCMV infection
Necroptosis is a lytic and inflammatory form of cell death that is highly constrained to mitigate detrimental collateral tissue damage and impaired...
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Serine-arginine protein kinases and their targets in viral infection and their inhibition
Accumulating evidence has consolidated the interaction between viral infection and host alternative splicing. Serine-arginine (SR) proteins are a...
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Immunomodulatory Effects of Vitamin D and Zinc on Viral Infection
Several nutrients are crucial in enhancing the immune system and preserving the structural integrity of bodily tissue barriers. Vitamin D (VD) and...
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Murine Models of Chronic Viral Infections and Associated Cancers
AbstractViruses are now recognized as bona fide etiologic factors of human cancer. Carcinogenic viruses include Epstein– Barr virus (EBV), high-risk...
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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis
Memory CD8 + T cells play a crucial role in infection and cancer and mount rapid responses to repeat antigen exposure. Although memory cell...
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Chronic brain damage in HIV-infected individuals under antiretroviral therapy is associated with viral reservoirs, sulfatide release, and compromised cell-to-cell communication
HIV infection has become a chronic and manageable disease due to the effective use of antiretroviral therapies (ART); however, several chronic...
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Distinct alterations of gut microbiota between viral- and non-viral-related hepatocellular carcinoma
AbstractAltered gut microbiota has been connected to hepatocellular carcinoma (HCC) occurrence and advancement. This study was conducted to identify...
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Multi-omics in Viral Microbiome
The human virus microbiome, also known as the human virome, comprises the viruses that reside on or within the human body, either as pathogens or as...
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The Role of Extracellular Vesicles in Pandemic Viral Infections
Extracellular vesicles (EVs), of diverse origin and content, are membranous structures secreted by a broad range of cell types. Recent advances in...
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Mechanistic insights into bone remodelling dysregulation by human viral pathogens
Bone-related diseases (osteopathologies) associated with human virus infections have increased around the globe. Recent findings have highlighted the...
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Can iron chelators ameliorate viral infections?
The redox reactivity of iron is a double-edged sword for cell functions, being either essential or harmful depending on metal concentration and...
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The roles of different microRNAs in the regulation of cholesterol in viral hepatitis
Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved...
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Association of Viral and Fungal Infections of the CNS During Immunosuppression
A major concern of immunodeficiency due to any cause is secondary infection by microorganisms, including virus and fungi. These microorganisms are...
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Slow viral propagation during initial phase of infection leads to viral persistence in mice
Immune evasion of pathogens can modify the course of infection and impact viral persistence and pathology. Here, using different strains of the...
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Immunomodulatory effects of cannabinoids against viral infections: a review of its potential use in SARS-CoV2 infection
The COVID-19 pandemic is a global health crisis affecting millions of people worldwide. Along with vaccine development, there is also a priority to...
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Impact of Prolonged SARS-CoV-2 Viral Shedding on COVID-19 Disease Outcome and Viral Dynamics
This article aimed to review the current literature on the impact of continuous shedding of the COVID-19 virus in infected patients in relation to...
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Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection
BackgroundAn animal model that can mimic the SARS-CoV-2 infection in humans is critical to understanding the rapidly evolving SARS-CoV-2 virus and...
