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Epigenetic roles of KDM3B and KDM3C in tumorigenesis and their therapeutic implications
Advances in functional studies on epigenetic regulators have disclosed the vital roles played by diverse histone lysine demethylases (KDMs), ranging...
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Cytogenetic status of patients with congenital malformations or suspected chromosomal abnormalities in Turkey: a comprehensive cytogenetic survey of 11,420 patients
Cytogenetic analysis is helpful in diagnostic workup of patients having prenatal or early postnatal medical problems and provides a basis for genetic...
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Erythrocyte miRNA-92a-3p interactions with PfEMP1 as determinants of clinical malaria
Based on the recently added high throughput analysis data on small noncoding RNAs in modulating disease pathophysiology of malaria, we performed an...
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Crosstalk between vault RNAs and innate immunity
PurposeVault (vt) RNAs are noncoding (nc) RNAs transcribed by RNA polymerase III (RNA Pol III) with 5ʹ-triphosphate (5ʹ-PPP) termini that play...
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How far musicality and perfect pitch are derived from genetic factors?
There is an agreement about joint genetic and environmental background of musical reception and performance. Musical abilities tend to cluster in...
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The Derivation and Characterization of Different Populations of Mesenchymal Stem Cells Isolated from Human Embryonic Stem Cell Line—SC7
AbstractA comparative analysis of three independent cell populations isolated from SC7 human embryonic stem cells was carried out. Cell properties...
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Dentine
The dentine, which constitutes most of the tooth, has a resilient structure because it is less dense than enamel. Dentine is synthesized by...
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Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
To identify candidate causal genes of asthma, we performed a genome-wide association study (GWAS) in UK Biobank on a broad asthma definition...
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Establishment and characterization of NCC-DDLPS3-C1: a novel patient-derived cell line of dedifferentiated liposarcoma
Dedifferentiated liposarcoma (DDLPS) is a highly malignant subtype of liposarcoma, with characteristic amplification of MDM2 and CDK4 (12q14-15). It...
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Regulation of the Tec family of non-receptor tyrosine kinases in cardiovascular disease
Tyrosine phosphorylation by protein tyrosine kinases (PTKs) is a type of post-translational modification. Tec kinases, which are a subfamily of...
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The molecular genetics of human appendicular skeleton
Disorders that result from de-arrangement of growth, development and/or differentiation of the appendages (limbs and digit) are collectively called...
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Fragile Bones Secondary to SMURF1 Gene Duplication
Studies on mice have shown that the Smad Ubiquitin Regulatory Factor-1 ( SMURF1 ) gene negatively regulates osteoblast function and the response to...
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Isolation and Characterization of Mesenchymal Stem Cells Derived from Different Regions of the Placenta of the Same Donor
AbstractTwo new nonimmortalized cell lines, MSC-PL-1 and MSC-PL-2, were established from different placenta regions of the same donor. Analysis of...
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Isoform alterations in the ubiquitination machinery impacting gastrointestinal malignancies
The advancement of RNAseq and isoform-specific expression platforms has led to the understanding that isoform changes can alter molecular signaling...
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The role of ADRB2 gene polymorphisms in malignancies
Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is...
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Vault RNAs: hidden gems in RNA and protein regulation
Non-coding RNAs are important regulators of differentiation during embryogenesis as well as key players in the fine-tuning of transcription and...
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Cytokines and Immunity
In this chapter the cytokine molecules and pathways present in teleost fish are described, with a focus on the different types of immunity with which...
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Novel functional proteins coded by the human genome discovered in metastases of melanoma patients
In the advanced stages, malignant melanoma (MM) has a very poor prognosis. Due to tremendous efforts in cancer research over the last 10 years, and...
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Effect of single nucleotide polymorphisms in SEPS1 and SEPP1 on expression in the protein level in metabolic syndrome in subjects with cardiovascular disease
Metabolic syndrome (MetS) results from the interaction between environmental and genetic factors. Several previous studies considered the role of...
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Differential Dynamics Underlying the Gln27Glu Population Variant of the β2-Adrenergic Receptor
The β 2 -adrenergic receptor (β 2 AR) is a membrane-bound G-protein-coupled receptor and an important drug target for asthma. Clinical studies report...
