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Anticandidal Activity and Mechanism of Action of Several Cationic Chimeric Antimicrobial Peptides
Antimicrobial peptides (AMPs) have recently been the subject of extensive research in both academia and commercial sectors because of their rapid,...
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A cleavable chimeric peptide with targeting and killing domains enhances LPS neutralization and antibacterial properties against multi-drug resistant E. coli
Pathogenic Escherichia coli is one of the most common causes of diarrhea diseases and its characteristic component of the outer...
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Rational design of bioactive chimeric construct by exploring archaeal antimicrobial peptides: an in silico approach
Novel peptide therapeutics have been the cardinal part of modern-day research. Such therapies are being incorporated to prevent the adverse effects...
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Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy
Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types, only a small subset of...
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ADPDB: A Comprehensive Knowledgebase of Manually Curated Peptides Against Dengue Virus
Dengue, a significant mosquito-borne disease, presents a global health challenge with limited treatment options. Recently, there have been estimates...
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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Noncanonical assembly, neddylation and chimeric cullin–RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex
Ubiquitin ligation is typically executed by hallmark E3 catalytic domains. Two such domains, ‘cullin–RING’ and ‘RBR’, are individually found in...
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Application of Antimicrobial Peptides in the Design and Production of Anticancer Agents
Antimicrobial peptides (AMPs) are part of the innate immune system of various species. In addition to extensive studies on their probable application...
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological...
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Recent Patents and FDA-Approved Drugs Based on Antiviral Peptides and Other Peptide-Related Antivirals
In spite of existing cases of severe viral infections with a high mortality rate, there are not enough antiviral drugs and vaccines available for the...
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Why to Study Peptides from Venomous and Poisonous Animals?
Venom and poison peptides are powerful biological weapons and have proven immense pharmacological potential because of their high binding affinity to...
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Validation of Chimeric Fusion Peptides Using Proteomics Data
Chimeric RNAs as well as their fused protein products have therapeutic applications ranging from diagnostics to being used as therapeutic target....
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Will Peptides Help to Stop COVID-19?
AbstractPeptides are widely used for the diagnostics, prevention, and therapy of certain human diseases. How useful can they be for the disease...
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Therapeutic peptides for coronary artery diseases: in silico methods and current perspectives
Many drug formulations containing small active molecules are used for the treatment of coronary artery disease, which affects a significant part of...
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Antimicrobial Peptides Targeting Streptococcus mutans: Current Research on Design, Screening and Efficacy
Antimicrobial peptides (AMPs) are small-molecule peptides that play a vital role in the nonspecific immune defense system of organisms. They mainly...
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An Updated Review on Recent Advances in the Usage of Novel Therapeutic Peptides for Breast Cancer Treatment
Breast cancer is among the most frequently occurring cancer for women globally. Conventional therapies for breast cancer are found to be expensive...
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Chimeric Antigen Receptor (CAR)-Based Cell Therapy for Type 1 Diabetes Mellitus (T1DM); Current Progress and Future Approaches
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys insulin-producing pancreatic β-cells. Insulin replacement therapy is currently...
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A Robust Strategy Against Multi-Resistant Pathogens in Oral Health: Harnessing the Potency of Antimicrobial Peptides in Nanofiber-Mediated Therapies
A robust strategy is imperative to counteract multi-resistant pathogens within the oral cavity and mitigate the occurrence of dental-related...
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Bioactive peptides in fermented foods and their application: a critical review
Bioactive peptides are released during the production of fermented dairy, vegetables, fruits, legumes, fish, and meat products. The proteolytic...
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Breaking the ‘don’t eat me’ signal: in silico design of CD47-directed peptides for cancer immunotherapy
The leading cause of death worldwide is cancer. Although there are various therapies available to treat cancer, finding a successful one can be like...
