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Frontloading of stress response genes enhances robustness to environmental change in chimeric corals
BackgroundChimeras are genetically mixed entities resulting from the fusion of two or more conspecifics. This phenomenon is widely distributed in...
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Genome-wide identification and analysis of monocot-specific chimeric jacalins (MCJ) genes in Maize (Zea mays L.)
BackgroundThe monocot chimeric jacalins (MCJ) proteins, which contain a jacalin-related lectin (JRL) domain and a dirigent domain (DIR), are specific...
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Multidomain chimeric enzymes as a promising alternative for biocatalysts improvement: a minireview
Searching for new and better biocatalysts is an area of study in constant development. In nature, mechanisms generally occurring in evolution, such...
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CTNNBIP1-CLSTN1 functions as a housekee** chimeric RNA and regulates cell proliferation through SERPINE2
The conventional understanding that chimeric RNAs are unique to carcinoma and are the products of chromosomal rearrangement is being challenged....
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Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided in...
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Shifting the pH profiles of Staphylococcus epidermidis lipase (SEL) and Staphylococcus hyicus lipase (SHL) through generating chimeric lipases by DNA shuffling strategy
Enzymes are often required to function in a particular reaction condition by the industrial procedure. In order to identify critical residues...
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Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation
Mycoplasma hyopneumoniae ( M. hyopneumoniae ) is a primary agent of porcine enzootic pneumonia, a disease that causes significant economic losses to...
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Rise of the human-mouse chimeric brain models
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting...
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Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
PurposeSpecific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and therapeutic targets for...
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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Transcription factors in chimeric antigen receptor T-cell development
Chimeric antigen receptor (CAR) T-cell therapy is a new and innovative approach to treating cancers that has shown promising results in the treatment...
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological...
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Chimeric Antigen Receptor CAR-T Therapy on the Move: Current Applications and Future Possibilities
Purpose of ReviewChimeric antigen receptor CAR-T therapy is a rowing therapeutic approach in hematological malignancies and certain solid tumors....
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However,...
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Differential Activity of Genes with IS630/TC1/MARINER Transposon Fragments in the Genome of the Ctenophore Mnemiopsis leidyi
Mobile genetic elements (MGEs) have a significant impact on genome structure and function being also a source of new genes. As a result of “molecular...
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Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy
Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types, only a small subset of...
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Anticandidal Activity and Mechanism of Action of Several Cationic Chimeric Antimicrobial Peptides
Antimicrobial peptides (AMPs) have recently been the subject of extensive research in both academia and commercial sectors because of their rapid,...
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A canine-derived chimeric antibody with high neutralizing activity against canine parvovirus-2
Canine parvovirus-2 (CPV-2) infection causes serious multisystemic disease in dogs and many animal species worldwide. Previously, a monoclonal...
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Metabolome and transcriptome profiling reveals anthocyanin contents and anthocyanin-related genes of chimeric leaves in Ananas comosus var. bracteatus
BackgroundAnanas comosus var. bracteatus is a colorful plant used as a cut flower or landscape ornamental. The unique foliage color of this plant...
