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Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided in...
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Concept of Chimeric Organisms Such as Human/Non-Human Chimera (HNH-Chimera)
As an another direction in the xenotransplantation, chimeric organisms are recently represented in the regenerative medicine using the stem cells...
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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells
Muscle-specific tyrosine kinase myasthenia gravis (MuSK MG) is an autoimmune disease that causes life-threatening muscle weakness due to anti-MuSK...
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Treatment of allergic eosinophilic asthma through engineered IL-5-anchored chimeric antigen receptor T cells
Severe eosinophilic asthma (SEA) is a therapy-resistant respiratory condition with poor clinical control. Treatment efficacy and patient compliance...
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Chimeric antigen receptor-natural killer cells: a promising sword against insidious tumor cells
Natural killer (NK) cells are a critical component of innate immunity, particularly in initial cancer recognition and inhibition of additional tumor...
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Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma
Markers that predict response and resistance to chimeric antigen receptor (CAR) T cells in relapsed/refractory multiple myeloma are currently...
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CTNNBIP1-CLSTN1 functions as a housekee** chimeric RNA and regulates cell proliferation through SERPINE2
The conventional understanding that chimeric RNAs are unique to carcinoma and are the products of chromosomal rearrangement is being challenged....
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Current Challenges and Potential Strategies for Designing a New Generation of Chimeric Antigen Receptor-T cells with High Anti-tumor Activity in Solid Tumors
Purpose of ReviewCancer immunotherapy is a treatment made by activating and strengthening the effects of immune system cells that destroy atypical...
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Young glial progenitor cells competitively replace aged and diseased human glia in the adult chimeric mouse brain
Competition among adult brain cells has not been extensively researched. To investigate whether healthy glia can outcompete diseased human glia in...
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Human Multi-Chimeric Cell (HMCC) Therapy as a Novel Approach for Tolerance Induction in Transplantation
Cellular therapies are regarded as the most promising approach for inducing transplant tolerance without life-long immunosuppression in solid organ...
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Rise of the human-mouse chimeric brain models
Human-mouse chimeras offer advantages for studying the pathophysiology of human cells in vivo. Chimeric mouse brains have been created by engrafting...
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Enhanced radiation-induced immunogenic cell death activates chimeric antigen receptor T cells by targeting CD39 against glioblastoma
Chimeric antigen receptor (CAR)-T cells directed to solid tumors have been less effective, due in part to the low or lost expression of specific...
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Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells
The link between cancer and aberrant glycosylation has recently become evident. Glycans and their altered forms, known as tumour-associated...
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Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation
Mycoplasma hyopneumoniae ( M. hyopneumoniae ) is a primary agent of porcine enzootic pneumonia, a disease that causes significant economic losses to...
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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Methods of Machine Learning-Based Chimeric Antigen Receptor Immunological Synapse Quality Quantification
Chimeric Antigen Receptor (CAR)-mediated immunotherapy shows promising results for refractory blood cancers. Currently, six CAR-T drugs have been...
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However,...
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Design of a novel chimeric peptide via dual blockade of CD47/SIRPα and PD-1/PD-L1 for cancer immunotherapy
Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types, only a small subset of...
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Shifting the pH profiles of Staphylococcus epidermidis lipase (SEL) and Staphylococcus hyicus lipase (SHL) through generating chimeric lipases by DNA shuffling strategy
Enzymes are often required to function in a particular reaction condition by the industrial procedure. In order to identify critical residues...
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Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy
Adoptive cell therapy with chimeric antigen receptor (CAR)-engineered T cells (CAR-Ts) has emerged as an innovative immunotherapy for hematological...
