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Multidomain chimeric enzymes as a promising alternative for biocatalysts improvement: a minireview
Searching for new and better biocatalysts is an area of study in constant development. In nature, mechanisms generally occurring in evolution, such...
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A novel recombinant chimeric bio-adhesive protein consisting of mussel foot protein 3, 5, gas vesicle protein A, and CsgA curli protein expressed in Pichia pastoris
Despite various efforts to produce potent recombinant bio-adhesive proteins for medical purposes, efficient production of a safe and feasible...
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ProteināProtein Interaction: Bacterial Two Hybrid
The bacterial two-hybridBacterial two-hybrid (BACTH, for āBacterial Adenylate Cyclase-based Two-Hybridā) system is a simple and fast genetic approach...
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An enhanced activity and thermostability of chimeric Bst DNA polymerase for isothermal amplification applications
AbstractLoop-mediated isothermal amplification (LAMP) is a widely used method for clinical diagnosis, customs quarantine, and disease prevention....
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Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation
Mycoplasma hyopneumoniae ( M. hyopneumoniae ) is a primary agent of porcine enzootic pneumonia, a disease that causes significant economic losses to...
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Design and Production of a Chimeric Enzyme with Efficient Antibacterial Properties on Staphylococcus aureus
Improper use of antibiotics has alarmingly led to the emergence of antibiotic resistance. Hence, this necessitated an urgent need to find a suitable...
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CTNNBIP1-CLSTN1 functions as a housekee** chimeric RNA and regulates cell proliferation through SERPINE2
The conventional understanding that chimeric RNAs are unique to carcinoma and are the products of chromosomal rearrangement is being challenged....
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Long-term viable chimeric nephrons generated from progenitor cells are a reliable model in cisplatin-induced toxicity
Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided in...
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Shifting the pH profiles of Staphylococcus epidermidis lipase (SEL) and Staphylococcus hyicus lipase (SHL) through generating chimeric lipases by DNA shuffling strategy
Enzymes are often required to function in a particular reaction condition by the industrial procedure. In order to identify critical residues...
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Profile of chimeric RNAs and TMPRSS2-ERG e2e4 isoform in neuroendocrine prostate cancer
PurposeSpecific gene fusions and their fusion products (chimeric RNA and protein) have served as ideal diagnostic markers and therapeutic targets for...
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Design and characterization of chimeric Rabies-SARS-CoV-2 virus-like particles for vaccine purposes
AbstractDue to the high number of doses required to achieve adequate coverage in the context of COVID-19 pandemics, there is a great need for novel...
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In vitro assembly of chimeric virus-like particles composed of a porcine circovirus 2b capsid protein and a B-cell epitope of infectious bursal disease virus
ObjectivesTo develop a method for in vitro assembly of recombinant proteins expressed in E. coli into chimeric virus-like particles (cVLPs).
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Development of a chimeric protein based on a proteomic approach for the serological diagnosis of human tegumentary leishmaniasis
Leishmania braziliensis is responsible for most cases of human tegumentary leishmaniasis (HTL) and has caused a wide range of clinical...
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Chimeric Antigen Receptor CAR-T Therapy on the Move: Current Applications and Future Possibilities
Purpose of ReviewChimeric antigen receptor CAR-T therapy is a rowing therapeutic approach in hematological malignancies and certain solid tumors....
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Genome-wide identification and analysis of monocot-specific chimeric jacalins (MCJ) genes in Maize (Zea mays L.)
BackgroundThe monocot chimeric jacalins (MCJ) proteins, which contain a jacalin-related lectin (JRL) domain and a dirigent domain (DIR), are specific...
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Chimeric antigen receptor-based natural killer cell immunotherapy in cancer: from bench to bedside
Immunotherapy has rapidly evolved in the past decades in the battle against cancer. Chimeric antigen receptor (CAR)-engineered T cells have...
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Design of a novel chimeric peptide via dual blockade of CD47/SIRPĪ± and PD-1/PD-L1 for cancer immunotherapy
Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types, only a small subset of...
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In silico analyses and design of a chimeric protein containing epitopes of SpaC, PknG, NanH, and SodC proteins for the control of caseous lymphadenitis
AbstractCaseous lymphadenitis (CLA) is an infectious disease that affects goats and sheep causing drastic impacts on milk and meat production and is...
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Frontloading of stress response genes enhances robustness to environmental change in chimeric corals
BackgroundChimeras are genetically mixed entities resulting from the fusion of two or more conspecifics. This phenomenon is widely distributed in...
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Synergistic effect of chimeric antigen receptor modified with Bcl-2 on enhanced solid tumour targeting
Engineered T cells expressing chimeric antigen receptors (CARs) have shown remarkable therapeutic effects on haematological malignancies. However,...
