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Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3
Chemokine receptors are a family of G-protein-coupled receptors with key roles in leukocyte migration and inflammatory responses. Here, we present...
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Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)
BackgroundThe incidence of multiple myeloma (MM), a type of blood cancer affecting monoclonal plasma cells, is rising. Although new drugs and...
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“Glyco-sulfo barcodes” regulate chemokine receptor function
Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including...
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Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation
To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors developed that capitalizes on specificity, redundancy,...
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Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization
BackgroundThe human CXC chemokine receptor 2 (CXCR2) is a G protein-coupled receptor (GPCR) interacting with multiple chemokines ( i.e. , CXC...
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Proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2 and its putative mouse ortholog MRGPRB2
Patients with idiopathic pulmonary fibrosis show a strongly upregulated expression of chemokine CXCL14, whose target is still unknown. Screening of...
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Structural insights into the activation and inhibition of CXC chemokine receptor 3
The chemotaxis of CD4 + type 1 helper cells and CD8 + cytotoxic lymphocytes, guided by interferon-inducible CXC chemokine 9–11 (CXCL9–11) and CXC...
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Chemerin attracts neutrophil reverse migration by interacting with C–C motif chemokine receptor-like 2
Neutrophil reverse migration (rM) is a recently identified phenomenon in which neutrophils migrate away from the inflammatory site back into the...
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Optimization of Physical Parameters for the Enhanced Expression of Recombinant Chemokine Receptors D6 and DARC in Pichia pastoris
AbstractD6 and DARC proteins had been reported as decoy chemokine receptors in cancer study. In this study, electrotransformation of Pichia pastoris ...
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Nitration of chemokine CXCL8 acts as a natural mechanism to limit acute inflammation
Chemokine CXCL8 is a key facilitator of the human host immune response, mediating neutrophil migration, and activation at the site of infection and...
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Identification of a non-canonical chemokine-receptor pathway suppressing regulatory T cells to drive atherosclerosis
CCL17 is produced by conventional dendritic cells, signals through CCR4 on regulatory T (T reg ) cells and drives atherosclerosis by suppressing T reg ...
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C-C motif chemokine receptor 2 and 7 synergistically control inflammatory monocyte recruitment but the infecting virus dictates monocyte function in the brain
Inflammatory monocytes (iMO) are recruited from the bone marrow to the brain during viral encephalitis. C-C motif chemokine receptor (CCR) 2...
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Evolutionary traits and functional roles of chemokines and their receptors in the male pregnancy of the Syngnathidae
Vertebrates have developed various modes of reproduction, some of which are found in Teleosts. Over 300 species of the Syngnathidae (seahorses,...
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Modeling of Olfactory Receptors
Olfactory receptors (ORs) form the largest subfamily within class A G protein-coupled receptors (GPCRs). No experimental structural data of any OR is...
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A review of the pleiotropic actions of the IFN-inducible CXC chemokine receptor 3 ligands in the synovial microenvironment
Chemokines are pivotal players in instigation and perpetuation of synovitis through leukocytes egress from the blood circulation into the inflamed...
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A multi-cellular molecular signaling and functional network map of C–C motif chemokine ligand 18 (CCL18): a chemokine with immunosuppressive and pro-tumor functions
The C–C Motif Chemokine Ligand 18 (CCL18) is a beta-chemokine sub-family member with immunomodulatory functions in primates. CCL18-dependent...
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Chemokine CCL6 Plays Key Role in the Inhibitory Effect of Vitamin A on Norovirus Infection
Norovirus (NoV) is the most common viral cause of acute gastroenteritis worldwide. Vitamin A has demonstrated the potential to protect against...
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IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells
BackgroundAntigenic stimulation through cross-linking the IgE receptor and epithelial cell-derived cytokine IL-33 are potent stimuli of mast cell...
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Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt...
