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Functional locus coeruleus imaging to investigate an ageing noradrenergic system
The locus coeruleus (LC), our main source of norepinephrine (NE) in the brain, declines with age and is a potential epicentre of protein pathologies...
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Multi-locus genome-wide association analysis for root and shoot traits at seedling stage in Ethiopian sorghum (Sorghum bicolor (L.) Moench) accessions
The Ethiopian sorghum germplasm possesses a vast array of genetic diversity across various traits, yet the genetic basis of most characteristics...
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Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and neurodegenerative diseases...
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Mitochondrial calcium uniporter channel gatekee** in cardiovascular disease
The mitochondrial calcium ( m Ca 2+ ) uniporter channel (mtCU) resides at the inner mitochondrial membrane and is required for Ca 2+ to enter the...
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Outlining cardiac ion channel protein interactors and their signature in the human electrocardiogram
Protein–protein interactions are essential for normal cellular processes and signaling events. Defining these interaction networks is therefore...
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Reference genomes of channel catfish and blue catfish reveal multiple pericentric chromosome inversions
BackgroundChannel catfish and blue catfish are the most important aquacultured species in the USA. The species do not readily intermate naturally but...
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Functional effects of disease-associated variants reveal that the S1–M1 linker of the NMDA receptor critically controls channel opening
The short pre-M1 helix within the S1–M1 linker (also referred to as the pre-M1 linker) between the agonist-binding domain (ABD, S1) and the M1...
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Dissecting the autism-associated 16p11.2 locus identifies multiple drivers in neuroanatomical phenotypes and unveils a male-specific role for the major vault protein
BackgroundUsing mouse genetic studies and systematic assessments of brain neuroanatomical phenotypes, we set out to identify which of the 30 genes...
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De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor
N-methyl- d -aspartate receptors (NMDARs) are members of the glutamate receptor family and participate in excitatory postsynaptic transmission...
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Discovery of Teleost Plasma Kallikrein/Coagulation Factor XI-Like Gene from Channel Catfish (Ictalurus punctatus) and the Evidence that the Protein Encoded by it Acts as a Lectin
Mammalian plasma kallikrein (PK) and coagulation factor XI (fXI) are serine proteases that play in the kinin–kallikrein cascade and in the blood...
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Extracellular Calcium Contributes to Orexin-Induced Postsynaptic Excitation of the Rat Locus Coeruleus Neurons
Noradrenergic neurons of the locus coeruleus (LC) receive projection from hypothalamus orexinergic neurons and express orexin receptor type 1 (OXR1)....
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CRISPR/Cas9-mediated knock-in of masu salmon (Oncorhyncus masou) elongase gene in the melanocortin-4 (mc4r) coding region of channel catfish (Ictalurus punctatus) genome
Channel catfish, Ictalurus punctatus , have limited ability to synthesize Ω-3 fatty acids. The ccβA-msElovl2 transgene containing masu salmon, Oncorhync...
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Tomato Ve-resistance locus: resilience in the face of adversity?
Main conclusionThe Ve -resistance locus in tomato acts as a resilience gene by affecting both the stress/defense cascade and growth, constituting a...
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Genetic dissection of maize (Zea mays L.) chlorophyll content using multi-locus genome-wide association studies
BackgroundThe chlorophyll content (CC) is a key factor affecting maize photosynthetic efficiency and the final yield. However, its genetic basis...
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Multi-locus phylogeny of the catfish genus Ictalurus Rafinesque, 1820 (Actinopterygii, Siluriformes) and its systematic and evolutionary implications
BackgroundIctalurus is one of the most representative groups of North American freshwater fishes. Although this group has a well-studied fossil...
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Fine map** and candidate gene analysis of a dravet syndrome modifier locus on mouse chromosome 11
Pathogenic variants in SCN1A result in a spectrum of phenotypes ranging from mild febrile seizures to Dravet syndrome, a severe infant-onset...
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Improved Growth and High Inheritance of Melanocortin-4 Receptor (mc4r) Mutation in CRISPR/Cas-9 Gene-Edited Channel Catfish, Ictalurus punctatus
Effects of CRISPR/Cas9 knockout of the melanocortin-4 receptor ( mc4r ) gene in channel catfish, Ictalurus punctatus , were investigated. Three sgRNAs...
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CCA identifies a neurophysiological marker of adaptation capacity that is reliably linked to internal locus of control of cognition in amnestic MCI
Locus of control (LOC) describes whether an individual thinks that they themselves (internal LOC) or external factors (external LOC) have more...
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Current and Emerging Technologies for the Analysis of the Genome-Wide and Locus-Specific DNA Methylation Patterns
DNA methylation is the most studied epigenetic modification, and altered DNA methylation patterns have been identified in cancer and more recently...
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Identification and characterization of An-4, a potential quantitative trait locus for awn development in rice
BackgroundAwn of rice is an important domestication trait closely associated with yield traits. Therefore, the identification of genes for awn...
