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Design, Synthesis, Molecular Docking Anticancer, Antiproliferative and Antioxidant Studies of Novel Chalcones Derivatives
AbstractA series of chalcones were synthesized and characterized by different spectroscopic techniques. The antioxidant properties of the compounds...
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Synthesis, characterization and evaluation of prenylated chalcones ethers as promising antileishmanial compounds
Drug therapy for leishmaniasis remains a major challenge as currently available drugs have limited efficacy, induce serious side-effects and are not...
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Phenolic chalcones lead to ion leakage from Gram-positive bacteria prior to cell death
Chalcones, valuable precursors for flavonoids, have important antibacterial and antifungal activities against bacteria, pathogens, harmful fungi and...
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Organohalogen chalcones: design, synthesis, ADMET prediction, molecular dynamics study and inhibition effect on acetylcholinesterase and carbonic anhydrase
In an effort to discover potential acetylcholinesterase (AChE) and carbonic anhydrase (CA) inhibitors, a novel series of organohalogen chalcone...
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Anchoring and Hydrophobic Nature of Coumarin in Newer Coumarin Based Chalcones: Synthesis, In Silico, and In Vitro Cell Viability Studies
AbstractCoumarin is active pharmacophore; to enhance the activity of chalcone we inserted coumarin along with other cyclic groups. Fewer pyrazolone...
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Chalcone derivatives disrupt cell membrane integrity of Saccharomyces cerevisiae cells and alter their biochemical composition
Fungal infections can be serious or life threatening in severe cases, and the need to discover and find novel antifungal agents persists. Chalcones...
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Exploration of chalcones and related heterocycle compounds as ligands of adenosine receptors: therapeutics development
Adenosine receptors (ARs) are ubiquitously distributed throughout the mammalian body where they are involved in an extensive list of physiological...
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Chalcone Schiff bases disrupt cell membrane integrity of Saccharomyces cerevisiae and Candida albicans cells
Chalcones have a variety of cellular protective and regulatory functions that may have therapeutic potential in many diseases. In addition, they are...
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Pharmacological insights into Flemingia grahamiana: a comprehensive review
Flemingia grahamiana ( F. grahamiana ), a member of the Fabaceae family, is a plant of immense scientific significance. Its adaptability to tropical...
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Occupancy of Flavonoids in Plants, Pathogen, and Opportunistic Fungi Interactions
Flavonoids are secondary metabolites found in plants that have antioxidant properties and pigments that give fruits and vegetables their vivid hues....
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Synergistic activity between conventional antifungals and chalcone-derived compound against dermatophyte fungi and Candida spp.
The scarce antifungal arsenal, changes in the susceptibility profile of fungal agents, and lack of adherence to treatment have contributed to the...
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PEG-mediated synthesis, antibacterial, antifungal and antioxidant studies of some new 1,3,5-trisubstituted 2-pyrazolines
A new series of 1,3,5-trisubstituted 2-pyrazoline derivatives (3a–l) are synthesized in good to excellent yields from the corresponding chalcones...
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The variability of terpenoids and flavonoids in native Lindera umbellata from the same region
The leaves and twigs of Lindera spp. have long been used as a herbal medicine and toothpicks in Japan. However, little is known about individual...
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Design, synthesis, antifungal activity, and structure–activity relationship studies of chalcones and hybrid dihydrochromane–chalcones
AbstractA series of ten chalcones ( 7a–j ) and five new dihydrochromane–chalcone hybrids ( 7k–o ) were synthesized and identified using spectroscopic...
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Furan-based Chalcone Annihilates the Multi-Drug-Resistant Pseudomonas aeruginosa and Protects Zebra Fish Against its Infection
The emergence of carbapenem-resistant Pseudomonas aeruginosa , a multi-drug-resistant bacteria, is becoming a serious public health concern. This...
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Selective in vitro Synergistic Evaluation of Probiotic Tolerant morpholinyl- and 4-ethylpiperazinyl-Imidazole-chalcone Derivatives on Gastrointestinal System Pathogens
Imidazole-chalcone compounds are recognised for their broad-spectrum antimicrobial properties. Probiotic-friendly, selective new-generation...
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Synthesis, antibiotic modifying activity, ADMET study and molecular docking of chalcone (E)-3-(2,4-dichlorophenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one in strains of Staphylococcus aureus carrying MepA efflux pumps
The Staphylococcus aureus bacteria is a Gram-positive, immobile, non-spore bacterium, with catalase and positive coagulase, among other...
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Design, synthesis and neuraminidase inhibitory activity of 4-methyl-5-(3-phenylacryloyl) thiazoles
A series of 4-methyl-5-(3-phenylacryloyl)thiazoles based on chalcones were designed, synthesized and evaluated for their influenza neuraminidase (NA)...
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Preparation, In Silico Studies, In Vitro Antibacterial and Antioxidantal Activity of 4,6-Disubstituted Dihydropyrimidine Thiones
AbstractHerein, we discuss the synthesis, in silico studies, antibacterial and antioxidantal activities of titled compounds, which are with...
