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Regulation of primary cilia disassembly through HUWE1-mediated TTBK2 degradation plays a crucial role in cerebellar development and medulloblastoma growth
Development of the cerebellum requires precise regulation of granule neuron progenitor (GNP) proliferation. Although it is known that primary cilia...
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Identification and characterization of transcribed enhancers during cerebellar development through enhancer RNA analysis
BackgroundThe development of the brain requires precise coordination of molecular processes across many cell-types. Underpinning these events are...
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Wdr4 promotes cerebellar development and locomotion through Arhgap17-mediated Rac1 activation
Patients with mutations of WDR4, a substrate adaptor of the CUL4 E3 ligase complex, develop cerebellar atrophy and gait phenotypes. However, the...
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Evaluation of histological and ultrastructural changes provoked by prenatal tramadol on postnatal cortical cerebellar neuronal development in rats: possible implication of Ki67, GFAP and MicroRNA-7/P53 signalling trajectories
Tramadol is a novel centrally acting analgesic. Despite, its implementation during pregnancy may impair neuronal survival and synaptic development in...
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Activation of TrkB signaling mitigates cerebellar anomalies caused by Rbm4-Bdnf deficiency
A molecular and functional link between neurotrophin signaling and cerebellar foliation is lacking. Here we show that constitutive knockout of two...
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Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits
BackgroundApnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces...
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Single-cell spatial transcriptomic analysis reveals common and divergent features of develo** postnatal granule cerebellar cells and medulloblastoma
BackgroundCerebellar neurogenesis involves the generation of large numbers of cerebellar granule neurons (GNs) throughout development of the...
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Single-cell multi-omics analysis of lineage development and spatial organization in the human fetal cerebellum
Human cerebellum encompasses numerous neurons, exhibiting a distinct developmental paradigm from cerebrum. Here we conducted scRNA-seq, scATAC-seq...
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Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis
The tendency of brain cells to undergo apoptosis in response to exogenous events varies across neural development, with apoptotic threshold dependent...
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Transcriptome programs involved in the development and structure of the cerebellum
In the past two decades, mounting evidence has modified the classical view of the cerebellum as a brain region specifically involved in the...
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MAG induces apoptosis in cerebellar granule neurons through p75NTR demarcating granule layer/white matter boundary
MAG (Myelin-associated glycoprotein) is a type I transmembrane glycoprotein expressed by Schwann cells and oligodendrocytes, that has been implicated...
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Developmental timing-dependent organization of synaptic connections between mossy fibers and granule cells in the cerebellum
The long-standing hypothesis that synapses between mossy fibers (MFs) and cerebellar granule cells (GCs) are organized according to the origins of...
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Trim32 suppresses cerebellar development and tumorigenesis by degrading Gli1/sonic hedgehog signaling
Sonic hedgehog (SHH) signaling is crucial for the maintenance of the physiological self-renewal of granule neuron progenitor cells (GNPs) during...
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Identification of novel cerebellar developmental transcriptional regulators with motif activity analysis
BackgroundThe work of the FANTOM5 Consortium has brought forth a new level of understanding of the regulation of gene transcription and the cellular...
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Growth cone repulsion to Netrin-1 depends on lipid raft microdomains enriched in UNC5 receptors
During brain development, Uncoordinated locomotion 5 (UNC5) receptors control axonal extension through their sensing of the guidance molecule...
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The effects of N6-methyladenosine RNA methylation on the nervous system
Epitranscriptomics, also known as “RNA epigenetics”, is a type of chemical modification that regulates RNA. RNA methylation is a significant...
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Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth
During mammalian brain development, neural progenitor cells proliferate extensively but can ensure the production of correct numbers of various types...
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A neurodevelopmental epigenetic programme mediated by SMARCD3–DAB1–Reelin signalling is hijacked to promote medulloblastoma metastasis
How abnormal neurodevelopment relates to the tumour aggressiveness of medulloblastoma (MB), the most common type of embryonal tumour, remains...
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Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development
BackgroundJoubert syndrome and related disorders (JSRD) and Jeune syndrome are multisystem ciliopathy disorders with overlap** phenotypes. There...
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Cryptic developmental events determine medulloblastoma radiosensitivity and cellular heterogeneity without altering transcriptomic profile
It is unclear why medulloblastoma patients receiving similar treatments experience different outcomes. Transcriptomic profiling identified subgroups...
