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Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming
Experimental studies have shown that chromatin modifiers have a critical effect on cellular reprogramming, i.e., the conversion of differentiated...
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Stage II oesophageal carcinoma: peril in disguise associated with cellular reprogramming and oncogenesis regulated by pseudogenes
IntroductionPseudogenes have been implicated for their role in regulating cellular differentiation and organismal development. However, their role in...
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p16High senescence restricts cellular plasticity during somatic cell reprogramming
Despite advances in four-factor (4F)-induced reprogramming (4FR) in vitro and in vivo, how 4FR interconnects with senescence remains largely under...
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Comparative roadmaps of reprogramming and oncogenic transformation identify Bcl11b and Atoh8 as broad regulators of cellular plasticity
Coordinated changes of cellular plasticity and identity are critical for pluripotent reprogramming and oncogenic transformation. However, the...
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Reprogramming fibroblast into human iBlastoids
The study of early human embryogenesis has relied on the use of blastocysts donated to research or simple stem cell culture systems such as...
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Mitochondrial metabolic reprogramming in diabetic kidney disease
Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial...
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Cellular reprogramming is driven by widespread rewiring of promoter-enhancer interactions
BackgroundLong-range interactions between promoters and cis -regulatory elements, such as enhancers, play critical roles in gene regulation. However,...
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Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and the diseases it causes, with transient expression of...
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In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
The induction of cellular reprogramming via expression of the transcription factors Oct4 , Sox2 , Klf4 and c‐Myc (OSKM) can drive dedifferentiation of...
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Partial Cell Reprogramming as a Way to Revitalize Living Systems
AbstractAging and associated diseases are acute problems of modern biology and medicine. Although aging cannot currently be prevented, its impact on...
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Direct Cardiac Reprogramming: Current Status and Future Prospects
Advances in cellular reprogramming articulated the path for direct cardiac lineage conversion, bypassing the pluripotent state. Direct cardiac...
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Recent advances and future prospects in direct cardiac reprogramming
Cardiovascular disease remains a leading cause of death worldwide despite important advances in modern medical and surgical therapies. As human adult...
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MacroH2A histone variants modulate enhancer activity to repress oncogenic programs and cellular reprogramming
Considerable efforts have been made to characterize active enhancer elements, which can be annotated by accessible chromatin and H3 lysine 27...
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Recent Advances in Biochemical Reprogramming Network Under Drought Stress in Soybean
Global climatic changes and the increasing human population have severely threatened global food security. Under abiotic stresses, metabolic...
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A fast chemical reprogramming system promotes cell identity transition through a diapause-like state
Cellular reprogramming by only small molecules holds enormous potentials for regenerative medicine. However, chemical reprogramming remains a slow...
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A new advanced cellular model of functional cholinergic-like neurons developed by reprogramming the human SH-SY5Y neuroblastoma cell line
Modeling human neuronal properties in physiological and pathological conditions is essential to identify novel potential drugs and to explore...
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Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
BackgroundAfter myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial...
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NMMHC IIA triggered lipid metabolize reprogramming resulting in vascular endothelial cellular tight junction injury
Background and purposeNonmuscle myosin heavy chain IIA, played an essential role in the promotion of tight junction injury in vascular endothelial...
