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Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer
BackgroundProstate cancer (PCa) is an age-related malignancy in men with a high incidence rate. PCa treatments face many obstacles due to cancer cell...
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Long non-coding RNA DARS-AS1 promotes tumor progression by directly suppressing PACT-mediated cellular stress
Cancer cells evolve various mechanisms to overcome cellular stresses and maintain progression. Protein kinase R (PKR) and its protein activator...
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Professional Standards for Cellular Therapy: The Foundation for the Accreditation of Cellular Therapy (FACT)
The Foundation for the Accreditation of Cellular Therapy (FACT) was co-founded by the American Society for Transplantation and Cellular Therapy...
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Ciclopirox targets cellular bioenergetics and activates ER stress to induce apoptosis in non-small cell lung cancer cells
BackgroundLung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other...
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Australian Cellular Therapy Regulations
The Therapeutic Goods Administration (TGA) is a division within the Australian Government Department of Health. The TGA is the Australian...
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USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target
An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system...
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Quality Control of Cellular Therapy Products and Viral Vectors
Quality control of cellular therapy products is an essential component of determining their safety and efficacy. This chapter reviews the various...
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SFPQ and NONO Proteins and Long Non-Coding NEAT1 RNA: Cellular Functions and Role in the HIV-1 Life Cycle
AbstractAbout 20 years ago, large RNA–protein complexes called paraspeckles were discovered in cell nuclei. The main components of these complexes...
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Microtubule-Targeting Agents: Disruption of the Cellular Cytoskeleton as a Backbone of Ovarian Cancer Therapy
Microtubules are dynamic polymers composed of α- and β-tubulin heterodimers. Microtubules are universally conserved among eukaryotes and participate...
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Regulation of Clinical Research for Cellular and Gene Therapy Products in India
The understanding of disease biology and advances in cellular and molecular biology platforms have ushered in a new era of cell and gene based...
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Inferring cellular and molecular processes in single-cell data with non-negative matrix factorization using Python, R and GenePattern Notebook implementations of CoGAPS
Non-negative matrix factorization (NMF) is an unsupervised learning method well suited to high-throughput biology. However, inferring biological...
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Xenogeneic and Allogenic Cellular Rejection (CR)
In solid organ xenotransplantation, the humoral response of human immunity is a direct barrier due to its Abs binding to non-self-antigens of...
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Cellular Senescence
Cellular senescence was first defined as replicative senescence after the works of Hayflick. Later this concept was extended to many other pathways...
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Regulation of Cellular Therapy in the United States
In the United States, the Food and Drug Administration (FDA) is the jurisdictional authority for the regulation of cellular therapy products. The...
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How do prolonged anchorage-free lifetimes strengthen non-small-cell lung cancer cells to evade anoikis? – A link with altered cellular metabolomics
BackgroundMalignant cells adopt anoikis resistance to survive anchorage-free stresses and initiate cancer metastasis. It is still unknown how varying...
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Transport and Shipment of Cellular and Gene Therapy Products
Cell and gene therapies and regenerative medicine have shown demonstrable potential for the treatment of a plethora of life-threatening diseases, and...
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Hyperthermia for Targeting Cancer and Cancer Stem Cells: Insights from Novel Cellular and Clinical Approaches
The Cellular Heat Shock Response and in particular heat shock protein activation are vital stress reactions observed in both healthy and cancer...
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Cellular forgetting, desensitisation, stress and ageing in signalling networks. When do cells refuse to learn more?
Recent findings show that single, non-neuronal cells are also able to learn signalling responses develo** cellular memory. In cellular learning...
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Non-hippo kinases: indispensable roles in YAP/TAZ signaling and implications in cancer therapy
The transcriptional co-activators Yes-associated protein (YAP) and PDZ-binding domain (TAZ) are the known downstream effectors of the Hippo kinase...
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ISBT 128 in Labeling of Cellular Therapy Products
Cellular therapy products frequently need to cross multiple borders, continents, and jurisdictions from collection to administration to the...