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The modular biochemical reaction network structure of cellular translation
Translation is an essential attribute of all living cells. At the heart of cellular operation, it is a chemical information decoding process that...
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Epigenetic OCT4 regulatory network: stochastic analysis of cellular reprogramming
Experimental studies have shown that chromatin modifiers have a critical effect on cellular reprogramming, i.e., the conversion of differentiated...
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Microvascular destabilization and intricated network of the cytokines in diabetic retinopathy: from the perspective of cellular and molecular components
Microvascular destabilization is the primary cause of the inner blood-retinal barrier (iBRB) breakdown and increased vascular leakage in diabetic...
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A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis
Differential body responses to various stresses, infectious or noninfectious, govern clinical outcomes ranging from asymptoma to death. However, the...
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Do not overwork: cellular communication network factor 3 for life in cartilage
Cellular communication network factor (CCN) 3, which is one of the founding members of the CCN family, displays diverse functions. However, this...
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Expression and biological function of the cellular communication network factor 5 (CCN5) in primary liver cells
The cellular (centralized) communication network (CCN) factor protein family contains six small secreted cysteine-rich proteins sharing high...
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Recent progress on the role of cellular communication network factors (CCN) 3, 4 and 6 in regulating adiposity, liver fibrosis and pancreatic islets
CCN/WISP (cellular communication network factors, or Wnt-inducted secreted proteins) family of proteins consists of six extracellular matrix...
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Cellular communication network factor 1 promotes retinal leakage in diabetic retinopathy via inducing neutrophil stasis and neutrophil extracellular traps extrusion
BackgroundDiabetic retinopathy (DR) is a major cause of blindness and is characterized by dysfunction of the retinal microvasculature. Neutrophil...
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Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital processes such as mitochondrial respiration, gene...
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Map** cellular senescence networks in human diabetic foot ulcers
Cellular senescence, a cell fate defined by irreversible cell cycle arrest, has been observed to contribute to chronic age-related conditions...
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Breaking the crosstalk of the Cellular Tumorigenic Network by low-dose combination therapy in lung cancer patient-derived xenografts
Non-small cell lung cancer (NSCLC) is commonly diagnosed at advanced stages limiting treatment options. Although, targeted therapy has become...
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Stage II oesophageal carcinoma: peril in disguise associated with cellular reprogramming and oncogenesis regulated by pseudogenes
IntroductionPseudogenes have been implicated for their role in regulating cellular differentiation and organismal development. However, their role in...
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Assaying Spontaneous Network Activity and Cellular Viability Using Multi-Well Microelectrode Arrays
Microelectrode array (MEA) technology is a neurophysiological method that allows for the measurement of spontaneous or evoked neural activity to...
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Mitochondrial Network: Electric Cable and More
AbstractMitochondria in a cell can unite and organize complex, extended structures that occupy the entire cellular volume, providing an equal supply...
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Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression
Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar) histologic subtypes often coexist within a tumor tissue...
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Spatial map** of cellular senescence: emerging challenges and opportunities
Cellular senescence is a well-established driver of aging and age-related diseases. There are many challenges to map** senescent cells in tissues...
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Identification of potential microRNAs regulating metabolic plasticity and cellular phenotypes in glioblastoma
MicroRNAs (miRNAs) play important role in regulating cellular metabolism, and are currently being explored in cancer. As metabolic reprogramming in...
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Autophagy-dependent survival is controlled with a unique regulatory network upon various cellular stress events
Although autophagy is a type of programmed cell death, it is also essential for cell survival upon tolerable level of various stress events. For the...
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Unsupervised and supervised discovery of tissue cellular neighborhoods from cell phenotypes
It is poorly understood how different cells in a tissue organize themselves to support tissue functions. We describe the CytoCommunity algorithm for...
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Single-cell analysis of human prepuce reveals dynamic changes in gene regulation and cellular communications
BackgroundThe cellular and molecular dynamics of human prepuce are crucial for understanding its biological and physiological functions, as well as...
