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Epigenetic Reprogramming and Somatic Cell Nuclear Transfer
Epigenetics is an area of genetics that studies the heritable modifications in gene expression and phenotype that are not controlled by the primary...
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Partial Cell Reprogramming as a Way to Revitalize Living Systems
AbstractAging and associated diseases are acute problems of modern biology and medicine. Although aging cannot currently be prevented, its impact on...
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p16High senescence restricts cellular plasticity during somatic cell reprogramming
Despite advances in four-factor (4F)-induced reprogramming (4FR) in vitro and in vivo, how 4FR interconnects with senescence remains largely under...
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Harnessing stem cell and lineage reprogramming technology to treat cardiac fibrosis
Cardiac fibrosis is a pathological response characterized by excessive deposition of fibrous connective tissue within the heart. It typically occurs...
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A fast chemical reprogramming system promotes cell identity transition through a diapause-like state
Cellular reprogramming by only small molecules holds enormous potentials for regenerative medicine. However, chemical reprogramming remains a slow...
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Ranking reprogramming factors for cell differentiation
Transcription factor over-expression is a proven method for reprogramming cells to a desired cell type for regenerative medicine and therapeutic...
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NETISCE: a network-based tool for cell fate reprogramming
The search for effective therapeutic targets in fields like regenerative medicine and cancer research has generated interest in cell fate...
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Pancreatic Cell Fate Specification: Insights Into Developmental Mechanisms and Their Application for Lineage Reprogramming
Adult differentiated cells can be forced to switch identities from one cell type to another under the direction of specific transcription factors...
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PTP4A1 promotes oral squamous cell carcinoma (OSCC) metastasis through altered mitochondrial metabolic reprogramming
PTP4A1 (Protein tyrosine phosphatase 4A1) is a protein tyrosine phosphatase that regulates a range of pro-oncogenic signaling pathways. Here, we...
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Epigenetic Mechanisms of Cell Programming and Reprogramming
This book presents a major research program on epigenetic mechanisms of cell programming and reprogramming. The program was launched by the National...
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Reprogramming fibroblast into human iBlastoids
The study of early human embryogenesis has relied on the use of blastocysts donated to research or simple stem cell culture systems such as...
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Metabolic Reprogramming During B-Cell Differentiation
B cells engaging with antigen and secondary signals provided by T cell help, or ligands for Toll-like receptors, undergo a step-wise process of...
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Systematic single-cell dissecting reveals heterogeneous oncofetal reprogramming in the tumor microenvironment of gastric cancer
Oncofetal reprogramming of the tumor microenvironment is clinically relevant. This study used the non-negative matrix factorial (NMF) algorithm for...
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Distinguishing Between Endodermal and Pluripotent Stem Cell Lines During Somatic Cell Reprogramming
Mouse somatic cell reprogramming using Oct4, Sox2, Klf4 and c-Myc (OSKM) induces formation of two stem cell types: induced pluripotent stem (iPS)...
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Single-cell resolution analysis reveals the preparation for reprogramming the fate of stem cell niche in cotton lateral meristem
BackgroundSomatic embryogenesis is a major process for plant regeneration. However, cell communication and the gene regulatory network responsible...
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Direct Cardiac Reprogramming: Current Status and Future Prospects
Advances in cellular reprogramming articulated the path for direct cardiac lineage conversion, bypassing the pluripotent state. Direct cardiac...
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Mitochondrial metabolic reprogramming in diabetic kidney disease
Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial...
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Molecular Basis of Cell Reprogramming into iPSCs with Exogenous Transcription Factors
A striking discovery in recent decades concerning the transcription factor (TF)-dependent process was the production of induced pluripotent stem cell...
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Restoration of neuronal progenitors by partial reprogramming in the aged neurogenic niche
Partial reprogramming (pulsed expression of reprogramming transcription factors) improves the function of several tissues in old mice. However, it...
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Unraveling the 2,3-diketo-l-gulonic acid-dependent and -independent impacts of l-ascorbic acid on somatic cell reprogramming
Backgroundl -ascorbic acid (Asc) plays a pivotal role in regulating various biological processes, including somatic cell reprogramming, through...
