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Redifferentiation of genetically modified dedifferentiated chondrocytes in a microcavitary hydrogel
ObjectivesWe genetically modified dedifferentiated chondrocytes (DCs) using lentiviral vectors and adenoviral vectors encoding TGF-β3 (referred to as...
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Fat transplantation induces dermal adipose regeneration and reverses skin fibrosis through dedifferentiation and redifferentiation of adipocytes
BackgroundLocalized scleroderma causes cosmetic disfigurement, joint contractures, and other functional impairment, but no currently available...
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Section Immunostaining for Protein Expression and Cell Proliferation Studies of Regenerating Fins
Adult zebrafishZebrafish finsFins fully regenerate after resection, providing a highly accessible and remarkable vertebrate model of organ...
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Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury
Cardiomyocyte proliferation and dedifferentiation have fueled the field of regenerative cardiology in recent years, whereas the reverse process of...
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A cell transcriptomic profile provides insights into adipocytes of porcine mammary gland across development
BackgroundStudying the composition and developmental mechanisms in mammary gland is crucial for healthy growth of newborns. The mammary gland is...
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Global transcriptome profiling reveals differential regulatory, metabolic and hormonal networks during somatic embryogenesis in Coffea arabica
BackgroundSomatic embryogenesis (SE) is one of the most promising processes for large-scale dissemination of elite varieties. However, for many plant...
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TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7
Glaucoma is a multifactorial, irreversible blinding eye disease characterized by a large number of retinal ganglion cell (RGC) deaths. Müller...
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LGR5 Modulates Differentiated Phenotypes of Chondrocytes Through PI3K/AKT Signaling Pathway
Background:Tissue engineering is increasingly viewed as a promising avenue for functional cartilage reconstruction. However, chondrocyte...
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Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
The prevalent RNA alternative splicing (AS) contributes to molecular diversity, which has been demonstrated in cellular function regulation and...
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3D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells
The scarcity of suitable pancreas/islet donors, the lifelong need for potentially toxic antirejection drugs for allogeneic islet transplants and...
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Strategies of cell and cell-free therapies for periodontal regeneration: the state of the art
BackgroundPeriodontitis often causes irrevocable destruction of tooth-supporting tissues and eventually leads to tooth loss. Currently, stem...
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Mechanical compression creates a quiescent muscle stem cell niche
Tissue stem cell niches are regulated by their mechanical environment, notably the extracellular matrix (ECM). Skeletal muscles consist of bundled...
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Nutritive tissue rich in reserves in the cell wall and protoplast: the case of Manihot esculenta (Euphorbiaceae) galls induced by Iatrophobia brasiliensis (Diptera, Cecidomyiidae)
The galls can offer shelter, protection, and an adequate diet for the gall-inducing organisms. Herein, we evaluated the structure of Manihot esculenta ...
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Targeting pancreatic β cells for diabetes treatment
Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no pharmacotherapy can prevent the loss or dysfunction of...
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Stem Cell for Cartilage Repair
Several of the age-related joint diseases such as osteoarthritis lead to chondrocyte degeneration and loss of articular cartilage. Chondrocyte after...
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Stem Cell for Cartilage Repair
Several of the age-related joint diseases such as osteoarthritis lead to chondrocyte degeneration and loss of articular cartilage. Chondrocyte after...
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Plant biotechnology research with single-cell transcriptome: recent advancements and prospects
Key messageSingle-cell transcriptomic techniques have emerged as powerful tools in plant biology, offering high-resolution insights into gene...
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Global, neuronal or β cell-specific deletion of inceptor improves glucose homeostasis in male mice with diet-induced obesity
Insulin resistance is an early complication of diet-induced obesity (DIO)
1 , potentially leading to hyperglycaemia and hyperinsulinaemia, accompanied...
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Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress
Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates...
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Epigenetic resha** through damage: promoting cell fate transition by BrdU and IdU incorporation
BackgroundThymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, the precise mechanisms through...
