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Mechanically guided cell fate determination in early development
Cell fate determination, a vital process in early development and adulthood, has been the focal point of intensive investigation over the past...
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Decoding the principle of cell-fate determination for its reverse control
Understanding and manipulating cell fate determination is pivotal in biology. Cell fate is determined by intricate and nonlinear interactions among...
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Cancer stem cell fate determination: mito-nuclear communication
Cancer stem cells (CSCs) are considered to be responsible for tumor recurrence and metastasis. Therefore, clarification of the mechanisms involved in...
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Uncovering the role of TET2-mediated ENPEP activation in trophoblast cell fate determination
Early trophoblast differentiation is crucial for embryo implantation, placentation and fetal development. Dynamic changes in DNA methylation occur...
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An IRE1-proteasome system signalling cohort controls cell fate determination in unresolved proteotoxic stress of the plant endoplasmic reticulum
Excessive accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress, which is an underlying cause of major crop losses...
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Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions
BackgroundSpermatogonial stem cells (SSCs) are the foundation cells for continual spermatogenesis and germline regeneration in mammals. SSC...
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Metabolic determination of cell fate through selective inheritance of mitochondria
Metabolic characteristics of adult stem cells are distinct from their differentiated progeny, and cellular metabolism is emerging as a potential...
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Segregation of morphogenetic regulatory function of Shox2 from its cell fate guardian role in sinoatrial node development
Shox2 plays a vital role in the morphogenesis and physiological function of the sinoatrial node (SAN), the primary cardiac pacemaker, manifested by...
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Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury
BackgroundUnlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or...
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SHANK family on stem cell fate and development
SH3 and multiple ankyrin repeat domains protein (SHANK) 1, SHANK2, and SHANK3 encode a family of postsynaptic scaffolding proteins present at...
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Forkhead box O proteins: steering the course of stem cell fate
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately...
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Mitochondria in Mesenchymal Stem Cells: Key to Fate Determination and Therapeutic Potential
Mesenchymal stem cells (MSCs) have become popular tool cells in the field of transformation and regenerative medicine due to their function of cell...
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ISL1 controls pancreatic alpha cell fate and beta cell maturation
BackgroundGlucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these...
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Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate
Mitochondria serve as essential organelles that play a key role in regulating stem cell fate. Mitochondrial dysfunction and stem cell exhaustion are...
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Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression
BackgroundSpermatogonial stem cells (SSCs) provide a foundation for robust and continual spermatogenesis in mammals. SSCs self-renew to maintain a...
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Piezo protein determines stem cell fate by transmitting mechanical signals
Piezo ion channel is a mechanosensitive protein on the cell membrane, which contains Piezo1 and Piezo2. Piezo channels are activated by mechanical...
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A statistical method for quantifying progenitor cells reveals incipient cell fate commitments
Quantifying the number of progenitor cells that found an organ, tissue or cell population is of fundamental importance for understanding the...
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Time series single-cell transcriptional atlases reveal cell fate differentiation driven by light in Arabidopsis seedlings
Light serves as the energy source for plants as well as a signal for growth and development during their whole life cycle. Seedling de-etiolation is...
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Regulation of muscle stem cell fate
Skeletal muscle plays a critical role in human health. Muscle stem cells (MuSCs) serve as the major cell type contributing to muscle regeneration by...
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Alternative splicing of CARM1 regulated by LincGET-guided paraspeckles biases the first cell fate in mammalian early embryos
The heterogeneity of CARM1 controls first cell fate bias during early mouse development. However, how this heterogeneity is established is unknown....
