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Cell Cycle Map** Using Multiplexed Immunofluorescence
The development of technologies that allow measurement of the cell cycle at the single-cellSingle-cell level has revealed novel insights into the...
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Senescence and Cell Cycle Control
In response to various stresses, such as telomere shortening during continuous proliferation, oxidative stress, DNA damage and aberrant oncogene...
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Cell Cycle
The basis for reproduction of all organisms is a process called the cell cycle [75]. As the name implies, the cell cycle is an iterative, periodic...
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Cross Talk Between Metabolism and the Cell Division Cycle
Cell division requires a massive rewiring of cellular pathways, including molecular routes involved in providing energy for cell survival and...
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A modular systems biology analysis of cell cycle entrance into S-phase
A modular systems biology approach to the study of the cell cycle of the budding yeast Saccharomyces cerevisiae is presented. Literature on the...
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Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade
Epithelial ovarian cancer (EOC) is one of the most common malignant gynecological tumors with rapid growth potential and poor prognosis, however, the...
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Modulation of cell cycle increases CRISPR-mediated homology-directed DNA repair
BackgroundGene knock‐in (KI) in animal cells via homology‐directed repair (HDR) is an inefficient process, requiring a laborious work for screening...
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Whole-Mount Immunofluorescence Staining to Visualize Cell Cycle Progression in Mouse Oocyte Meiosis
Whole-mount immunofluorescence allows direct visualization of the cellular architecture within cells. Here, we apply this technique to mouse oocytes...
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The cell cycle, autophagy, and cell wall integrity pathway jointly governed by MoSwe1 in Magnaporthe oryzae
The cell cycle is pivotal to cellular differentiation in plant pathogenic fungi. Cell wall integrity (CWI) signaling plays an essential role in...
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Emerging cell cycle related non-coding RNA biomarkers from saliva and blood for oral squamous cell carcinoma
The unnotified or undifferentiable early stages of oral squamous cell carcinoma (OSCC) progression are the prime reasons for late-stage detection and...
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Sequential drug treatment targeting cell cycle and cell fate regulatory programs blocks non-genetic cancer evolution in acute lymphoblastic leukemia
BackgroundTargeted therapies exploiting vulnerabilities of cancer cells hold promise for improving patient outcome and reducing side-effects of...
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Allosteric regulation of CAD modulates de novo pyrimidine synthesis during the cell cycle
Metabolism is a fundamental cellular process that is coordinated with cell cycle progression. Despite this association, a mechanistic understanding...
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Cell cycle-linked vacuolar pH dynamics regulate amino acid homeostasis and cell growth
Amino acid homeostasis is critical for many cellular processes. It is well established that amino acids are compartmentalized using pH gradients...
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Impact of cell cycle on repair of ruptured nuclear envelope and sensitivity to nuclear envelope stress in glioblastoma
The nuclear envelope (NE) is often challenged by various stresses (known as “NE stress”), leading to its dysfunction. Accumulating evidence has...
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Temporal segregation of biosynthetic processes is responsible for metabolic oscillations during the budding yeast cell cycle
Many cell biological and biochemical mechanisms controlling the fundamental process of eukaryotic cell division have been identified; however, the...
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Cellograph: a semi-supervised approach to analyzing multi-condition single-cell RNA-sequencing data using graph neural networks
With the growing number of single-cell datasets collected under more complex experimental conditions, there is an opportunity to leverage single-cell...
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TFEB inhibition induces melanoma shut-down by blocking the cell cycle and rewiring metabolism
Melanomas are characterised by accelerated cell proliferation and metabolic reprogramming resulting from the contemporary dysregulation of the MAPK...
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Cell Cycle and Terminal Differentiation in Sinorhizobium meliloti
Sinorhizobium meliloti of the Alphaproteobacteria class has a fascinating spectrum of lifestyles, thriving as a free-living soil saprophyte, as an...
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Cellular Hallmarks and Regulation of the Diatom Cell Cycle
Diatoms are one of the oldest experimental models for studying the mitotic cell cycle, with microscopic descriptions of cell division dating back to...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...